Fibriuretinin synthesis method

A synthetic method, the technology of palmatine, applied in the direction of organic chemistry, etc., can solve the problems of harsh reaction conditions and lengthy synthetic routes, and achieve the effect of simple synthetic conditions, simple synthetic process and few steps
CN102040604AActive Publication Date: 2011-05-04YUNNAN PHYTOPHARML
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YUNNAN PHYTOPHARML
Publication Date
2011-05-04

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Abstract

The invention relates to a fibriuretinin synthesis method. The method takes berberine hydrochloride as a starting material and comprises the following steps: selectively carrying out decomposition reaction on methylenedioxy of the berberine hydrochloride to obtain ortho-dyhydroxyl berberine hydrochloride; carrying out methylation reaction on hydroxyl of the ortho-dyhydroxyl berberine hydrochloride and dimethyl sulfate, recrystallizing, and adding hydrochloric acid to regulate pH value to obtain the target product, i.e. fibriuretinin. The fibriuretinin synthesis method has less synthesis steps, simple technology, and high total yield of 49.3% and the raw materials are easy to collect, so as to reduce cost, improve production efficiency and contribute a new synthesis method for fibriuretinin chemosynthesis industrialization.
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Description

technical field

[0001] The invention relates to the technical field of chemical synthesis, in particular to a synthetic method of palmatine. Background technique

[0002] Palmatine, also known as rhubarb, palmatine hydrochloride, etc. (its chemical structure is as follows figure 1 Shown), this product is yellow needle-like crystal, odorless, very bitter taste. Chloride, yellow needle-like crystal (water), melting point 198-201°C (decomposition), extremely bitter taste, easily soluble in hot water, slightly soluble in water, slightly soluble in ethanol and chloroform, almost insoluble in ether.

[0003] At present, palmatine preparations are widely used clinically. For example, palmatine has broad-spectrum antibacterial and antiviral effects, significantly increases the multiple pharmacological effects of leukocyte phagocytosis of bacteria, and has good anti-inflammatory and immune-enhancing effects. As a clinical drug, palmatine is mainly used for clearing heat and det...

Claims

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