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Degradable nerve conduit with highly-oriented tube-in-tube structure and manufacturing method thereof

A nerve conduit and tube-in-tube technology, which is applied in the field of degradable nerve conduits and their preparation, can solve the problems of hindering the forward growth of regenerated nerve fibers, unable to reach the in-situ of regenerated tissue, and losing function, and achieves good biocompatibility. , promote regeneration and repair, improve the effect of fiber orientation

Inactive Publication Date: 2011-05-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the injury with a defect between the broken ends, the proliferation of the glial at the broken end and the peripheral connective tissue of the nerve will hinder the forward growth of the regenerated nerve fibers, so that the regenerated tissue cannot reach the original position and lose its function.

Method used

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  • Degradable nerve conduit with highly-oriented tube-in-tube structure and manufacturing method thereof
  • Degradable nerve conduit with highly-oriented tube-in-tube structure and manufacturing method thereof
  • Degradable nerve conduit with highly-oriented tube-in-tube structure and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Dissolve PHBV and PLGA (50:50) in chloroform at a mass ratio of 2:1 to prepare a polymer solution with a mass fraction of 6%; stir until clear without turbidity, and add NaCl with a particle size of 300 μm As a porogen, the mass fraction of NaCl is 10%; after mixing evenly, the polymer solution is cast into a cylindrical mold with a 4-channel inner diameter of 3mm to obtain an outer tubular substrate, and the casting process is repeated several times; Remove the mold after vacuuming, rinse the tubular substrate repeatedly with deionized water after the solvent is completely evaporated to remove the porogen, and finally vacuum dry to a constant temperature to obtain a high-porosity outer tubular substrate. The outer tubular substrate is 3 mm in diameter and has 4 channels.

[0036] (2) PHBV and chitosan are dissolved in trifluoroacetic acid with a mass ratio of 50:50, and a 5% polymer solution is prepared, and magnetically stirred until clear without turbidity; Elec...

Embodiment 2

[0039] (1) Dissolve PHBV and PCL in chloroform with a mass ratio of 2:1 to prepare a polymer solution with a mass fraction of 8%; stir until it is clear without turbidity, and add NH with a particle size of 300 μm 4 HCO 3 porogen, NH 4 HCO 3 The mass fraction is 10%; the polymer solution is cast into the inner diameter of 4mm after mixing evenly, and the outer tubular substrate is prepared in a cylindrical mold with 7 channels, and the casting process is repeated several times; the mold is removed after vacuuming, and the After the solvent is completely evaporated, it is first washed several times with acid, and then the tubular substrate is repeatedly rinsed with deionized water to remove the porogen, and finally vacuum-dried to a constant temperature to obtain a high-porosity outer tubular substrate. The outer tubular substrate is 4mm in diameter and has 7 channels.

[0040] (2) PHBV and collagen were dissolved in hexafluoroisopropanol at a mass ratio of 75:25, and a 10% ...

Embodiment 3

[0043] (1) Dissolve PCL and PLGA (50:50) in chloroform at a mass ratio of 1:1 to prepare a polymer solution with a mass fraction of 8%; stir until it is clear without turbidity, and add NH with a particle size of 300 μm 4 HCO 3 porogen, NH 4 HCO 3 The mass fraction is 10%; after mixing evenly, the polymer solution is cast into a cylindrical mold with a 6-channel inner diameter of 5mm to obtain an outer tubular substrate, and the casting process is repeated several times; the mold is removed after vacuuming, and the After the solvent is completely evaporated, it is first washed several times with acid, then repeatedly washed with deionized water to remove the porogen, and finally vacuum-dried to a constant temperature to obtain a high-porosity outer tubular substrate. The outer tubular substrate is 5 mm in diameter and has 6 channels.

[0044] (2) Dissolve PHBV and collagen in hexafluoroisopropanol at a mass ratio of 50:50, prepare a 12% polymer solution, and magnetically st...

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Abstract

The invention relates to a degradable nerve conduit with a highly-oriented tube-in-tube structure and a manufacturing method thereof. The degradable nerve conduit comprises an outer-layer tubular substrate and an inner small tube. The manufacturing method comprises the following steps of: (1) dissolving a degradable material into chloroform, adding a porogenic agent, uniformly stirring the solution, casting the solution into a mould, performing vacuum drying after the chloroform is volatilized, removing the mould and repeatedly flushing the casting with deionized water to obtain the outer-layer tubular substrate with a high void fraction after the porogenic agent is washed off; (2) dissolving the degradable material into an organic solvent to prepare spinning dope, injecting the spinning dope into an injector, performing electrostatic spinning under the action of a boost pump, and curling a fibrous membrane on the mould to form the small tube with a tubular structure; and (3) placing and fixing the small tube into a preserved tube arrangement cavity of the outer-layer tubular substrate, and performing sterilization to obtain the nerve conduit with the highly-oriented tube-in-tube structure. The product provided by the invention has high biocompatibility, low production cost and vast application prospect, and can be applied to the repair of a peripheral nervous system; and the preparation method is simple.

Description

technical field [0001] The invention belongs to the field of degradable nerve guide and its preparation, in particular to a degradable nerve guide with a highly oriented tube-in-tube structure and a preparation method thereof. Background technique [0002] Peripheral nerve injuries can be roughly divided into two categories: no defect between the stumps and a defect between the stumps. For the non-defective damage between the broken ends, the surgical methods such as adventitial anastomosis and perineural anastomosis are mainly used for direct anastomosis repair. However, for the injury with defects between the stumps, the proliferation of glia at the stumps and the peripheral connective tissue of the nerves will hinder the forward growth of the regenerated nerve fibers, so that the regenerated tissue will not reach the original position and lose its function. Therefore, the repair of the damaged peripheral nerve between the stumps is a major problem faced by the medical fi...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61L27/18A61L27/26
Inventor 杨庆邵梅玲郯志清沈新元张佩华陈璐王碧桥
Owner DONGHUA UNIV
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