Polymer nano hydrogel and preparation method thereof

A nano-hydrogel, polymer technology, applied in the field of hydrogel, can solve problems such as limitations, and achieve the effects of good stability, good degradability, and good biocompatibility

Active Publication Date: 2011-05-18
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the Chinese patent document with the application number 200610148155.5 discloses a temperature-sensitive chemically cross-linked hydrogel, which is an amphiphilic block composed of polyethylene glycol as a hydrophilic block and degradable polyester as a hydrophobic blo

Method used

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  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof
  • Polymer nano hydrogel and preparation method thereof

Examples

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Example Embodiment

[0046] The present invention also provides a method for preparing the polymer nanohydrogel described in the above technical scheme, including:

[0047] a) Mixing hydrophilic polymer, triethylamine and chloryl chloride, stirring reaction to obtain the first intermediate product, said hydrophilic polymer is polyethylene glycol or polyethylene glycol monomethyl ether, and said chloryl chloride has the formula (IV) Structure:

[0048]

[0049] Among them, 1≤t≤65;

[0050] b) Dissolve the first intermediate product and poly(L-glutamate)-b-poly(γ-2-chloroethyl-L-glutamate) in an organic solvent, and add sodium perselenide The aqueous solution is subjected to cross-linking reaction under anaerobic conditions, and the polymer nano hydrogel is obtained after dialysis.

[0051] In the present invention, a hydrophilic polymer, triethylamine and chloryl chloride are used as raw materials to prepare a terminal chlorine functionalized hydrophilic compound, that is, the first intermediate product, ...

Example

[0091] Examples 1 to 5 Preparation of polyethylene glycol monomethyl ether functionalized with chlorine at the end group

[0092] According to the amount of each raw material in Table 1, the polyethylene glycol monomethyl ether functionalized with terminal chlorine was prepared according to the following method:

[0093] Add 10g polyethylene glycol monomethyl ether and 100mL toluene into the reaction flask, after azeotropic dehydration, dissolve the obtained product in 100mL dry dichloromethane, cool to 0℃, add triethylamine, and then add chlorine dropwise Propionyl chloride was reacted at 0°C for 2 hours and then heated to 25°C. The reaction was continued for 24 hours under stirring with a stirring bar. After the reaction, the reaction mixture was filtered to obtain the filtrate, which was then settled with ether, filtered, washed, and dried in vacuum at 25°C for 24 hours to obtain Polyethylene glycol monomethyl ether chloropropionate. The chloropropionic acid polyethylene glycol...

Example Embodiment

[0098] Example 6 Preparation of chloroacetic acid polyethylene glycol monomethyl ether ester

[0099] Add 10 g of polyethylene glycol monomethyl ether with a number average molecular weight of 5000 and 100 mL of toluene into the reaction flask, after azeotropic dehydration, dissolve the obtained product in 100 mL of anhydrous dichloromethane, add 1.01 g after cooling to 0°C Triethylamine, then 4.52g of chloroacetyl chloride was added dropwise, reacted at 0°C for 2h, and then heated to 25°C. The reaction was continued for 24h under stirring with a stir bar. After the reaction, the reaction mixture was filtered to obtain the filtrate, which was then settled with ether and filtered. , Washing, and vacuum drying at 25° C. for 24 hours to obtain polyethylene glycol monomethyl ether chloroacetate. The number average molecular weight of the polyethylene glycol monomethyl ether chloroacetate is 5076, and the reaction yield is 92.1%.

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Abstract

The invention provides a polymer nano hydrogel. The polymer substrate of the polymer nano hydrogel comprises a hydrophilic chain section and a segmented copolymer. The hydrophilic chain section is connected with the segmented copolymer through selenous bounds, the segmented copolymer is subjected to intermolecular crosslink through selenous bounds, the hydrophilic chain section has a structure shown in the formula (I) or the formula (II), and the segmented copolymer has a structure shown in the formula (III). The invention further provides a preparation method of the polymer nano hydrogel, which comprises the following steps of: a) mixing hydrophilic polymer, triethylamine and chloroacetyl chloride, and stirring and reacting to obtain a first intermediate, wherein the hydrophilic polymer is polyethylene glycol or polyethylene glycol monomethyl ether, and the chloroacetyl chloride has a structure shown in the formula (IV); b) dissolving the first intermediate product and poly(L-glutamic acid)-b-poly(gamma-2-chloroethyl-L-glutamic acid) in an organic solvent, adding a sodium selenite water solution, performing crosslink reaction under anaerobic conditions, and dialyzing to obtain the polymer nano hydrogel.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a polymer nano hydrogel and a preparation method thereof. Background technique [0002] Sustained drug release is the combination of drugs and drug carriers, through diffusion, penetration, etc. in the body, so that the drug can be continuously released at an appropriate concentration, so as to fully exert the efficacy of the drug. Polymers such as polyesters and polyamino acids have become the main materials for drug carriers due to their advantages of non-toxicity, good biocompatibility, and biodegradability. [0003] Polymers usually act as drug carriers in the form of solid polymers, polymer nanomicelles or polymer nanohydrogels. Among them, solid polymers need to be implanted into the human body, which will cause surgical trauma; polymer nanomicelles are nano-sized core-shells formed by self-assembly of amphiphilic block copolymers with hydrophilic blocks and hydrophobic ...

Claims

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Application Information

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IPC IPC(8): C08L71/08C08L77/04C08K3/30C08J3/24C08J3/075C08G65/48C08G69/48A61K47/34A61K47/10
Inventor 庄秀丽丁建勋汤朝晖陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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