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Adhesion prevention material formed by physical crosslinking hydrogel composition and preparation method and application thereof

A physical cross-linking and anti-adhesion technology, which is applied in the field of polymer materials and medical treatment, can solve the problems that the gelation temperature is not suitable for human body application, no longer has heat-sensitive gelation, and loses sol-gel transition. Effects of promoting wound healing, good biocompatibility, and preventing adhesion

Inactive Publication Date: 2011-05-25
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) Exceeding a certain composition and / or molecular weight, it can only be completely dissolved in water or partially or completely become precipitated, thus losing the sol-gel transition and no longer having the relevant heat-sensitive gelling performance;
[0008] (2) In addition, even if some polymers can have heat-sensitive properties, their gelation temperature is not suitable for human application;
[0009] (3) The adjustment range and kinetic process of its degradation rate have certain limitations, which limits its medical use

Method used

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  • Adhesion prevention material formed by physical crosslinking hydrogel composition and preparation method and application thereof
  • Adhesion prevention material formed by physical crosslinking hydrogel composition and preparation method and application thereof
  • Adhesion prevention material formed by physical crosslinking hydrogel composition and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0057] Add PEG (1500) into a 250 ml three-necked flask, heat the oil bath to 150°C, and vacuum filter for three hours while stirring to remove the residual moisture in the PEG, and then add DL-lactide with a molar ratio of 4:1 And glycolide, after heating under vacuum to make it melt completely, add 120 μl stannous octoate, the oil bath is heated up to 160 ℃, continue to react under argon atmosphere for 24 hours. After the reaction was completed, vacuum filtration was performed for two hours to remove unreacted monomers and low-boiling products. The initial product was dissolved in dichloromethane solution and precipitated with ether, the yield was about 80%. The number-average and weight-average molecular weight ( M n , M w ) were 5510 and 6390, respectively, and the molecular weight distribution coefficient ( M w / M n ) is 1.16. The copolymer itself does not have thermosensitive gelling properties in water.

Embodiment 2

[0059] Add single-ended methoxypolyethylene glycol MPEG (550) into a 250 ml three-necked flask, heat the oil bath to 150°C, and vacuum filter for three hours while stirring to remove residual moisture in MPEG, and then add the molar ratio of 3:1 DL-lactide and glycolide, heated under vacuum to melt completely, then added 120 μl stannous octoate, heated the oil bath to 160°C, and continued the reaction for 24 hours under an argon atmosphere. After the reaction was completed, vacuum filtration was performed for two hours to remove unreacted monomers and low-boiling products. The initial product was dissolved in dichloromethane solution and precipitated with ether, the yield was about 85%. The number-average and weight-average molecular weight ( M n , M w ) were 3550 and 4620, respectively, and the molecular weight distribution coefficient ( M w / M n ) is 1.30. The copolymer itself does not have thermosensitive gelling properties in water.

Embodiment 3

[0061] Add polyethylene glycol (1000) and PLGA ( M n 4750, M w 6020, LA / GA=1 / 1), the mixture was heated under vacuum to make it completely melted, and the oil bath was heated to 160°C for condensation reaction for 18 hours. After the reaction is complete, the initial product is dissolved in dichloromethane solution and precipitated with a large amount of ether, and the yield is about 85%. Measure the number average and weight average molecular weight ( M n , M w ) are 6520 and 8340 (PLGA-PEG-PLGA, Copolymer-15), respectively, molecular weight distribution coefficient ( M w / M n ) is 1.28. The copolymer itself does not have thermosensitive gelling properties in water.

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Abstract

The invention belongs to the field of high polymer material and medical technology, and particularly relates to adhesion prevention material formed by physical crosslinking hydrogel composition and a preparation method and application thereof. The hydrogel composition material is formed by mixture of two polymers or more than two polymers, the water system of the hydrogel composition material can be thermo-sensitively gelated along with the rise of temperature, i.e. when the temperature is lower than gel transformation temperature, the composition is liquid, when the temperature raises to sol-gel transformation temperature or above the sol-gel transformation temperature, the composition spontaneously forms gel; the polymer generally is segmented copolymer formed by polyethylene glycol (PEG) being hydrophilic block and degradable polyester being lyophobic block, and polymer for mixing singly possibly has not the property of thermosensitive gelation. The hydrogel composition material has the effect of wound surface adhesion prevention after the hydrogel composition material is coated on the postoperative wound surface.

Description

technical field [0001] The invention belongs to the field of polymer materials and medical technology, and specifically relates to a physically cross-linked hydrogel composition material, the water system of which can undergo heat-sensitive gelation as the temperature rises, that is, when the temperature is lower than the gel transition temperature , the composition is liquid, and when the temperature rises to the sol-gel transition temperature or above, the composition spontaneously forms a gel. The material can be injected and coated on postoperative wounds, and used as a medical postoperative anti-adhesion barrier material. Background technique [0002] Postoperative adhesion is an important problem that has plagued the surgical field for a long time. Adhesions after abdominal surgery can lead to a series of complications such as pelvic pain, intestinal obstruction, and infertility. In tendon repair surgery, adhesions can cause motor dysfunction in patients. At present,...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14
Inventor 丁建东俞麟张正
Owner FUDAN UNIV
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