Method for preparing pH sensitive in-situ gel nano slow-release eye drop
An in-situ gel and slow-release eye technology, applied in the field of pharmaceuticals, can solve problems such as short duration, low bioavailability of drugs, frequent administration, etc., to increase permeability, prolong drug action time, and reduce adverse reactions Effect
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Embodiment 1
[0026] (1) Take by weighing 100mg poly(lactic acid-glycolic acid) copolymer (average molecular weight is 30000, and LA:GA copolymerization ratio is 50:50 in the molecular chain segment) is dissolved in 5ml dichloromethane and makes organic phase; With 30mg levofloxacin Dissolve in 0.3ml of distilled water to make the water phase; add the water phase to the organic phase, and obtain an emulsion after ultrasonication for 1 minute; add the emulsion dropwise to 100ml of polyethylene glycol 1000 vitamin E succinate with a mass fraction of 0.025% In the aqueous solution, stir at 800rpm for 6 hours; centrifuge at 2000rpm to remove large particles of impurities and aggregates, filter with an ultrafiltration tube at 5000rpm, and wash with water for 3 times to remove the emulsifier to obtain nanoparticles loaded with levofloxacin.
[0027] (2) Weigh 0.15g of hydroxypropyl methylcellulose and dissolve it in 40ml of distilled water, and let it stand overnight at 4°C to obtain a clear solut...
Embodiment 2
[0031] (1) Weigh 100mg of poly(lactic acid-glycolic acid) copolymer (the average molecular weight is 30000, and the LA:GA copolymerization ratio in the molecular segment is 50:50) and dissolve it in 5ml of methylene chloride to make an organic phase; Dissolve ciclovir in 0.2ml of distilled water to make water phase; add the water phase to the organic phase, and obtain an emulsion after ultrasonication for 1 minute; add dropwise the emulsion to 100ml of 0.025% polyethylene glycol 1000 vitamin E In the succinate aqueous solution, stir at 800rpm for 6 hours; centrifuge at 2000rpm to remove large particles of impurities and agglomerates, filter with an ultrafiltration tube at 5000rpm, and wash with water for 3 times to remove the emulsifier to obtain nanoparticles loaded with levofloxacin.
[0032] (2) Weigh 0.01g of hydroxypropyl methylcellulose and dissolve it in 40ml of distilled water, and let it stand overnight at 4°C to obtain a clear solution; weigh 0.5g of polyacrylic acid ...
Embodiment 3
[0036](1) Weigh 100mg poly(lactic acid-glycolic acid) copolymer (average molecular weight is 30000, LA:GA copolymerization ratio in molecular segment is 50:50) and dissolve in 5ml N'N'-dimethylformamide to prepare into an organic phase; dissolve 20mg of dexamethasone in 0.2ml of absolute ethanol to make an aqueous phase; add the aqueous phase to the organic phase, and obtain an emulsion after ultrasonication for 1 minute; add the emulsion dropwise to 100ml with a mass fraction of 0.025% In polyethylene glycol 1000 vitamin E succinate aqueous solution, stir at 800rpm for 6 hours; centrifuge at 2000rpm to remove large particles of impurities and agglomerates, filter with an ultrafiltration tube at 5000rpm, wash with water for 3 times to remove emulsifiers and obtain nanoparticles loaded with levofloxacin medicine.
[0037] (2) Weigh 0.25g of hydroxypropyl methylcellulose and dissolve it in 40ml of distilled water, and let it stand overnight at 4°C to obtain a clear solution; weig...
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