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Temperature-sensitive hydrogel based on chemical cross-linking gel granules and preparation method of temperature-sensitive hydrogel

A temperature-sensitive hydrogel and chemical cross-linking technology, applied in the fields of biomaterials and polymers, can solve problems such as drug inactivation and limited material application.

Inactive Publication Date: 2012-08-22
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this material is that high temperature is unfavorable to many drugs, especially protein drugs with higher conformational structures, which may lead to drug inactivation and limit the application of materials.

Method used

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  • Temperature-sensitive hydrogel based on chemical cross-linking gel granules and preparation method of temperature-sensitive hydrogel
  • Temperature-sensitive hydrogel based on chemical cross-linking gel granules and preparation method of temperature-sensitive hydrogel
  • Temperature-sensitive hydrogel based on chemical cross-linking gel granules and preparation method of temperature-sensitive hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Add 30g of dihydroxypolyethylene glycol (1500) into a 500ml three-neck flask, remove water under vacuum at 130°C for 4 hours, cool to 70°C with argon, add 50g of lactide, 10g of glycolide, 26mg of stannous octoate ( containing a small amount of toluene), evacuated at 100°C for 30 minutes, passed argon, and heated to 130°C for 12 hours. After the reaction was completed, the product was poured out while it was hot. After cooling, the product was dissolved in dichloromethane and ether precipitated. Dissolve 15 g of the above block polymer in dichloromethane, slowly add acryloyl chloride (4 mL) in dichloromethane solution (50 mL) dropwise, and use triethylamine (4 mL) as an acid-binding agent, in an ice bath Add dropwise for 8 hours, then stir and react at room temperature for 48 hours. Precipitate with glacial ether and dry in vacuo to obtain the desired macromonomer. Synthesis schematic as figure 1 shown.

Embodiment 2

[0032] Example 2 Dissolve 1 g of the macromonomer obtained in Example 1 in 100 mL of deionized water, add benzoin dimethyl ether (0.03 g) in ethanol solution (0.2 mL), stir for 12 hours, and irradiate with 254 nm ultraviolet lamp for 0.5 hours to obtain Nano nanoparticles. The solution was freeze-dried to obtain the desired nanoparticles.

Embodiment 3

[0033] Example 3 The nanoparticles obtained in Example 2 were formulated into a 15 wt% solution, and when the temperature rose to 34 °C, a solution-gel transition was presented, realizing the overall physical gelation transition. Such as figure 2 shown.

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Abstract

The invention discloses a temperature-sensitive hydrogel based on chemical cross-linking gel granules and a preparation method of the temperature-sensitive hydrogel, belonging to the technical field of macromolecular and biological materials. The hydrogel is a chemical cross-linking nanometre granule water solution with a certain concentration, and chemical cross-linking nanometre granules are uniformly dispersed in the water; the nanometre granules are formed by introducing crosslinkable groups to both ends of segmented copolymer with amphipathicity composed of polyethylene glycol / polyester,dissolving in water according to a certain concentration, spontaneously assembling into micelles and adding an initiator to initiate polymerizing cross-linking. As the temperature rises, the gel granules at a certain concentration can generate solution-gel transition. The multi-scale gel is suitable for being used as a pharmaceutical carrier biological material.

Description

technical field [0001] The invention belongs to the technical field of macromolecules and biomaterials, and in particular relates to a temperature-sensitive hydrogel with degradable chemically cross-linked gel particles as building blocks and a preparation method thereof. Background technique [0002] Hydrogel is a three-dimensional network composed of hydrophilic substances. Hydrogel has become a research hotspot of biomaterials because of its similarity to biological tissues and good biocompatibility. According to their crosslinking mechanism, they can be divided into physical hydrogels and chemical hydrogels, each of which has its own advantages. Chemical hydrogels have high mechanical strength, a wide range of controllability, and are easy to prepare materials with similar mechanical strengths to tissues; physical hydrogels are simple to prepare, and some physical hydrogels that use temperature changes or pH changes to undergo solution-gel transitions The glue is easy ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34C08G63/91C08G63/664C08J3/28C08J3/24C08J3/075
Inventor 丁建东常广涛
Owner FUDAN UNIV