Application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation

A technology of pyrroloquinoline quinone and hematopoietic function, which is applied in the field of medicine, and can solve problems such as difficult to meet clinical medication and combat preparation drugs, difficult to control the content and quality of anti-radiation functional factors, and difficult to use accurate dosages.
CN102178679AActive Publication Date: 2011-09-14INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
3 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Publication Date
2011-09-14

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation, in particular application of the pyrroloquinoline quinone (PQQ) or a pharmaceutically acceptable salt or ester of the pyrroloquinoline quinine or a medicinal composition containing either salt or ester to preparing drugs for treating bone marrow hemopoietic damage. The tested drug PQQ can be administrated with a certain promoting effect on the recovery of white blood cells, thus being beneficial to the elimination of damaged erythropoiesis factors and the recovery of reticulocytes ratio. A tested drug group and a positive drug group are higher than a contrast group in the number of bone marrow cells, and tend to increase in bone marrow DNA (deoxyribonucleic acid) content. As indicated, the PQQ can promote the recovery of bone marrow hemopoietic function.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of pyrroloquinoline quinone. Background technique

[0002] Radiation injury is tissue damage caused by radiation exposure. The degree of radiation damage is related to the radiation dose, duration and radiation rate. The area of ​​the body irradiated by radiation and the distribution of radiation in the body also affect the effect of radiation damage. Acute radiation injury caused by high-dose radiation can cause damage to multiple organs in the body, including the hematopoietic system, brain, and gastrointestinal tract. Cerebral syndrome is caused by very high doses (greater than 30Gy) and is often life-threatening. Bone marrow is an important tissue responsible for human hematopoiesis and is extremely sensitive to radiation. If the total irradiation dose exceeds 6Gy, the body often dies due to hematopoietic dysfunction.

[0003] There are many kinds of drugs current...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More