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Application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation

A technology of pyrroloquinoline quinone and hematopoietic function, which is applied in the field of medicine, and can solve problems such as difficult to meet clinical medication and combat preparation drugs, difficult to control the content and quality of anti-radiation functional factors, and difficult to use accurate dosages.

Active Publication Date: 2011-09-14
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs targeting free radicals and oxidative damage are often derived from natural animals and plants, and have complex components. It is difficult to control the content and quality of anti-radiation functional factors, and the dosage is not easy to be accurate, and it is difficult to meet the requirements of clinical medication and combat preparation drugs.

Method used

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  • Application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation
  • Application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation
  • Application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 pyrroloquinoline quinone PQQ pair 60 Effects of Coγ-ray Radiation on Survival of Mice

[0018] 1 Purpose of the test

[0019] using mice 60 Coγ-ray irradiation model to observe the effect of pyrroloquinoline quinone on the survival of mice.

[0020] 2 Experimental materials

[0021] 2.1 Test sample

[0022] Drug name: pyrroloquinoline quinone, PQQ for short, can be obtained commercially, or can be prepared according to the method disclosed in (Acta Microbiology Sinica. 2007, 47(6):982-986.).

[0023] 2.2 Positive control drug

[0024] Drug name: Nilestriol (Nilestriol) was purchased from Room 9, Institute of Radiation Medicine, Academy of Military Medical Sciences.

[0025] Product batch number: 20081007.

[0026] Properties: white powder.

[0027] 2.3 Experimental animals

[0028] Adult KM mice were bred in the Experimental Animal Center of Academy of Military Medical Sciences. The body weight of the mice was 16.0-18.0 g. Experimental animal lic...

Embodiment 2

[0059] Example 2 Effect of pyrroloquinoline quinone on bone marrow hematopoietic function of mice irradiated with Co gamma rays

[0060] 1 Purpose of the test

[0061] using mice 60 Coγ-ray irradiation model to observe the effect of pyrroloquinoline quinone on the hematopoietic system of mice.

[0062] 2 Experimental materials

[0063] Same as Example 1

[0064] 2.3 Experimental animals

[0065] Same as Example 1

[0066] 3 Experimental methods

[0067] 3.1 Irradiation conditions

[0068] 60 Co gamma rays, the absorbed dose rate is 236.05cGy / min. The absorbed dose in the survival test of irradiated mice was 4.0Gy. The results of Example 1 show that 8.0Gy is a lethal dose, and 4.0Gy is a sublethal dose, because the therapeutic effect of PQQ on bone marrow hematopoietic radiation injury will be studied. If a lethal dose is used, the mice will die during the experiment, thereby affecting the experiment. Analysis of results. Therefore, this embodiment adopts a sublethal...

Embodiment 3

[0128] Embodiment 3 pyrrole quinoline quinone solution

[0129] Prescription: pyrroloquinoline quinone 40mg

[0130] 0.9% normal saline 100mL

[0131] Weigh 40 mg of pyrroloquinoline quinone powder, add 100 mL of physiological saline, stir to completely dissolve the powder, and prepare a 0.4 mg / mL pyrroloquinoline quinone aqueous solution preparation.

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Abstract

The invention discloses application of pyrroloquinoline quinone to the bone marrow hemopoietic function after recovery of radiation, in particular application of the pyrroloquinoline quinone (PQQ) or a pharmaceutically acceptable salt or ester of the pyrroloquinoline quinine or a medicinal composition containing either salt or ester to preparing drugs for treating bone marrow hemopoietic damage. The tested drug PQQ can be administrated with a certain promoting effect on the recovery of white blood cells, thus being beneficial to the elimination of damaged erythropoiesis factors and the recovery of reticulocytes ratio. A tested drug group and a positive drug group are higher than a contrast group in the number of bone marrow cells, and tend to increase in bone marrow DNA (deoxyribonucleic acid) content. As indicated, the PQQ can promote the recovery of bone marrow hemopoietic function.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of pyrroloquinoline quinone. Background technique [0002] Radiation injury is tissue damage caused by radiation exposure. The degree of radiation damage is related to the radiation dose, duration and radiation rate. The area of ​​the body irradiated by radiation and the distribution of radiation in the body also affect the effect of radiation damage. Acute radiation injury caused by high-dose radiation can cause damage to multiple organs in the body, including the hematopoietic system, brain, and gastrointestinal tract. Cerebral syndrome is caused by very high doses (greater than 30Gy) and is often life-threatening. Bone marrow is an important tissue responsible for human hematopoiesis and is extremely sensitive to radiation. If the total irradiation dose exceeds 6Gy, the body often dies due to hematopoietic dysfunction. [0003] There are many kinds of drugs current...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61K31/661A61K31/57A61K31/375A61K31/355A61K38/44A61P7/06A61P39/06A61P17/16A61P17/18
Inventor 张惟材汪建华熊向华周满祥魏琳申云飞
Owner INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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