3D porous bracket with mesoporous biological glass coating and preparation method thereof

A bioglass, three-dimensional porous technology, applied in coatings, medical science, prostheses, etc., can solve problems such as unfavorable cell adhesion, poor hydrophilicity, and slightly weak mechanics

Inactive Publication Date: 2011-09-21
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the polymer has good flexibility and strong plasticity, but generally pure synthetic degradable polymers are difficult to directly bond with bone tissue in the body; and the hydrophilicity is poor, which is not conducive to cell adhesion; the degradation is slow, and the degradation The product is an acidic substance; the mechanics are slightly weaker (V.V.Seregin, Biomaterials, 2006(27): 4745-4754)

Method used

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  • 3D porous bracket with mesoporous biological glass coating and preparation method thereof
  • 3D porous bracket with mesoporous biological glass coating and preparation method thereof
  • 3D porous bracket with mesoporous biological glass coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of polylactic acid scaffold PM-3 coated with mesoporous bioactive glass M80S

[0028] 0.3 g of polylactic acid (PLLA) was dissolved in 10 ml of 1,4-dioxane to make a transparent solution with a mass fraction of 3%. The solution was poured into polytetrafluoroethylene molds, and immediately placed in a refrigerator at -20°C for 24 hours. The mold was submerged in 80% ethanol aqueous solution at -20°C, extracted for 3 days, and the liquid was changed every 8 hours. After the extraction is complete, remove the mold, put it in a fume hood, dry it at room temperature for 1 day, and then dry it under vacuum at room temperature overnight.

[0029] Add 4.0 grams of triblock copolymer P123 to 1 gram of 0.5M hydrochloric acid and 60 grams of absolute ethanol. After completely dissolving, add 6.7 grams of TEOS, 1.4 gram of Ca(NO3)2·4H2O and 0.73 gram of TEP, and stirred at room temperature for one day to obtain the precursor sol of the mesoporous bioactive...

Embodiment 2

[0032] Example 2: Preparation of polylactic acid scaffold PM-6 coated with mesoporous bioactive glass M80S

[0033] The polylactic acid scaffold was prepared according to the steps and raw material ratio of Example 1, and the precursor sol of M80S was prepared. The dipping and volatilization self-assembly process of polylactic acid scaffolds was repeated 6 times, followed by extraction and drying. The ordered hexagonal structure of the mesoporous glass coating remained unchanged, the mass fraction of inorganic components in the composite scaffold increased to 40%, and the porosity of the scaffold decreased to 63.7±1.2% (Table 1).

[0034] Bioactivity detection of mesoporous bioactive glass M80S coated polylactic acid scaffold PM-6:

[0035] Freshly prepared simulated body fluid SBF has similar ion concentrations to human plasma. Take a certain volume of SBF and put it into a polyethylene container, dip the stent into the SBF, keep at 37°C for 6 hours, 1 day, and 3 days respe...

Embodiment 3

[0040] Example 3: Preparation of polylactic acid scaffold PM-9 coated with mesoporous bioactive glass M80S

[0041] The polylactic acid scaffold was prepared according to the steps and raw material ratio of Example 1, and the precursor sol of M80S was prepared. The dipping and volatilization self-assembly process of PLA scaffolds was repeated 9 times, followed by extraction and drying. The ordered hexagonal structure of the mesoporous glass coating remained unchanged, the mass fraction of inorganic components in the composite scaffold increased to 50%, and the porosity of the scaffold decreased to 52.4% (Table 1).

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Abstract

The invention relates to a 3D porous bracket with a mesoporous biological glass coating and a preparation method thereof. Polymer porous bracket substrate is prepared by utilizing freeze-extraction technique, by dipping precursory sol of the mesoporous biological glass and the approach of evaporation-induced self-assembly, a novel 3D porous bracket with a mesoporous biological glass coating for tissue engineering. The preparation method has the advantages of simple to carry out, low cost, high efficiency and easy operation. The 3D porous bracket with a mesoporous biological glass coating prepared by the invention is suitable for drug loading and releasing, sterilization, inducing the adhesion and proliferation of cells, with good application prospect in tissue engineering.

Description

technical field [0001] The invention relates to a three-dimensional porous support with a mesoporous biological glass coating and a preparation method thereof, belonging to the field of support materials and mesoporous materials for tissue engineering. Background technique [0002] In the current medical field, tissue regeneration technology, as a new generation of medical technology, has aroused extensive interest and research of scientists in various disciplines. Tissue regenerative therapy technology mainly relies on porous scaffolds made of biodegradable materials. Cells are planted on the scaffolds and then cultured and expanded in vitro. The resulting tissues or organs are implanted into the damaged parts of the body to achieve non-invasive repair of wounds. and the purpose of reconstructing function (M. J. Mondrnos, Biomaterials, 2006(27): 4399-4408). [0003] In the process of tissue reconstruction, the three-dimensional porous scaffold provides a space for cells to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/18A61L27/56A61L27/54
Inventor 朱敏施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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