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Chitosan derivative self-crosslinked antimicrobial hydrogel using oxidized konjak as crosslinking agent and preparation method thereof

A chitosan derivative and self-crosslinking technology, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., to achieve good biocompatibility, low environmental pollution, and excellent antibacterial performance

Active Publication Date: 2011-09-21
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the reports on chitosan derivative hydrogel mainly focus on the preparation of hydrogel with formaldehyde, glutaraldehyde, etc. Cross-linked antibacterial hydrogel materials have not been reported

Method used

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  • Chitosan derivative self-crosslinked antimicrobial hydrogel using oxidized konjak as crosslinking agent and preparation method thereof
  • Chitosan derivative self-crosslinked antimicrobial hydrogel using oxidized konjak as crosslinking agent and preparation method thereof
  • Chitosan derivative self-crosslinked antimicrobial hydrogel using oxidized konjak as crosslinking agent and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0028] Preparation of oxidized konjac containing dialdehyde groups:

[0029] Weigh 5g of konjac flour, measure 100ml of absolute ethanol and put it into a single-necked flask, and wrap the flask with tinfoil to keep it away from light. Add 100ml of distilled water and 15g of sodium periodate, stir and react at 20°C for 6 hours, then add 1ml of ethylene glycol to terminate the reaction, add 5g of sodium chloride for precipitation to obtain the reaction product, and then wash the product obtained after precipitation with ethanol repeatedly Get it purified.

[0030] Preparation of nano silver solution:

[0031] Weigh 0.01g of silver nitrate, dissolve it in 50ml of distilled water, add 5ml of sodium citrate solution with a concentration of 6% by weight, and react at 50°C for 2h to obtain a nano silver solution.

Embodiment 1

[0033] Put carboxymethyl chitosan in a 100ml glass beaker, add 50ml of distilled water, stir and dissolve, and filter the solution with a microporous membrane with a pore size of 0.22 μm to obtain carboxymethyl chitosan with a concentration of 6% by weight. Aqueous solution, wherein adding oxidized konjac and nano-silver solution, the weight percent that described oxidized konjac accounts for reactant gross weight (the aqueous solution of carboxymethyl chitosan, oxidized konjac and nano-silver solution reactant gross weight) is 4%, so Said nano-silver solution accounts for reactant total weight (the total weight of the aqueous solution of carboxymethyl chitosan, oxidized konjac and nano-silver solution reactant) percent by weight is 0.1%, treats its self-crosslinking at 30 ℃ (promptly solution stops flowing ) to obtain oxidized konjac-carboxymethyl chitosan self-crosslinking antibacterial hydrogel. The scanning electron microscope images of the oxidized konjac-carboxymethyl ch...

Embodiment 2

[0038] Carboxymethyl chitosan is placed in a 100ml glass beaker, 50ml of distilled water is added, stirred and dissolved, and the resulting solution is filtered through a microporous membrane with a pore size of 0.22 μm to obtain carboxymethyl chitosan with a concentration of 20% by weight. Aqueous solution, adding oxidized konjac and nano-silver solution wherein, the weight percent that described oxidized konjac accounts for reactant gross weight (the total weight of the aqueous solution of carboxymethyl chitosan, oxidized konjac and nano-silver solution reactant) is 16%, The nano-silver solution accounts for 0.05% by weight of the total weight of the reactants (the total weight of the aqueous solution of carboxymethyl chitosan, oxidized konjac and nano-silver solution reactants), and it is self-crosslinked at 20° C. to obtain oxidized konjac -Carboxymethyl chitosan self-crosslinking antibacterial hydrogel.

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Abstract

The invention relates to a chitosan derivative self-crosslinked antimicrobial hydrogel using oxidized konjak as a crosslinking agent and a preparation method thereof. The invention is characterized in that the chitosan derivative self-crosslinked antimicrobial hydrogel is prepared by adding oxidized konjak and nano silver antimicrobial agent into a chitosan derivative water solution to carry out self-crosslinking reaction, wherein the oxidized konjak is prepared by adding konjak flour into anhydrous alcohol and adding a sodium periodate water solution to carry out reaction at normal temperature; the chitosan derivative is one of water-soluble carboxymethyl chitosans and hydroxypropyl chitosans; and the nano silver antimicrobial agent is a self-made nano silver solution. The chitosan derivative self-crosslinked antimicrobial hydrogel provided by the invention has the advantages of no toxicity for human body, high swelling capacity, high biocompatibility and favorable antimicrobial property.

Description

technical field [0001] The invention relates to the field of macromolecular materials, in particular to a chitosan derivative self-crosslinking antibacterial hydrogel with oxidized konjac as a crosslinking agent and a preparation method thereof. Background technique [0002] Carboxymethyl chitosan is a water-soluble derivative of chitosan after carboxymethylation reaction. The introduction of carboxymethyl group greatly improves the water solubility of chitosan on the one hand, and on the other hand makes it a kind of An amphoteric polymer electrolyte containing an amino group and a carboxyl group. Compared with chitosan, carboxymethyl chitosan has good water solubility, good biocompatibility and bioadhesion, and can be completely degraded in vivo. [0003] Hydroxypropyl chitosan is the C in the chitosan molecule 6 Another water-soluble derivative obtained by introducing a hydroxypropyl group into a hydroxyl group through an etherification reaction. The introduction of a h...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L5/02C08K3/08C08J3/24C08J3/075C08B37/02A61L15/18A61K31/722A61P7/04
Inventor 樊李红潘晓然江澜周月郑化
Owner WUHAN UNIV OF TECH
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