Unlock instant, AI-driven research and patent intelligence for your innovation.

Thermosensitive polymeric microcapsules and preparation method and use thereof

A high-molecular microcapsule and temperature-sensitive technology, which is applied in the preparation of microcapsules, microcapsules, and microspheres, can solve the problems of complex template removal, achieve potential utilization value, improve the space utilization rate of the capsule core, and increase the load capacity. The effect of the dose

Inactive Publication Date: 2013-02-27
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem of complex template removal in the prior art, the present invention provides a temperature-sensitive polymer microcapsule and its preparation method and application. The preparation process is simple, it is a hollow structure, and it has high drug loading and controllable drug Release, can be used as a drug carrier, especially a carrier loaded with water-soluble anti-tumor drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thermosensitive polymeric microcapsules and preparation method and use thereof
  • Thermosensitive polymeric microcapsules and preparation method and use thereof
  • Thermosensitive polymeric microcapsules and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Preparation of polyacrylic acid-poly N-isopropylacrylamide microcapsules

[0036] In a 500mL stirred reactor, dissolve 0.20g of hydroxypropyl cellulose with a number average molecular weight of 100,000 in 35mL of distilled water, stir at room temperature to completely dissolve it, and obtain a clear and transparent solution. Then add 0.20 gram of acrylic acid to the solution, and add 0.1 mol / L of ascorbic acid solution and 0.5 mL of hydrogen peroxide solution into the reactor under stirring condition as initiator. After reacting at 35° C. for 2 hours, a milky white hydroxypropyl cellulose-polyacrylic acid nanoparticle aqueous phase dispersion was obtained. In a 100mL beaker, blend 0.20 g of monomer N-isopropylacrylamide, 0.15 g of cross-linking agent N,N'-methylenebisacrylamide, and 0.05 g of surfactant sodium lauryl sulfate. Dissolve in 15mL of distilled water and stir at room temperature to dissolve completely to obtain N-isopropylacrylamide solution fo...

Embodiment 2

[0037] Embodiment 2: Preparation of polyacrylic acid-poly N-isopropylacrylamide microcapsules

[0038] In a 500mL stirred reactor, dissolve 0.20g of hydroxypropyl cellulose with a number average molecular weight of 100,000 in 35mL of distilled water, stir at room temperature to completely dissolve it, and obtain a clear and transparent solution. Then add 0.20 gram of acrylic acid to the solution, and add 0.1 mol / L of ascorbic acid solution and 0.5 mL of hydrogen peroxide solution into the reactor under stirring condition as initiator. After reacting at 35° C. for 2 hours, a milky white hydroxypropyl cellulose-polyacrylic acid nanoparticle aqueous phase dispersion was obtained. In a 100mL beaker, 0.20 g of monomer N-isopropylacrylamide, 0.20 g of crosslinking agent N,N'-methylenebisacrylamide, and 0.05 g of surfactant sodium lauryl sulfate were blended and Dissolve in 15mL of distilled water and stir at room temperature to dissolve completely to obtain N-isopropylacrylamide so...

Embodiment 3

[0039] Embodiment 3: Preparation of polyacrylic acid-poly N-isopropylacrylamide microcapsules

[0040] In a 500mL stirred reactor, dissolve 0.20g of hydroxypropyl cellulose with a number average molecular weight of 100,000 in 35mL of distilled water, stir at room temperature to completely dissolve it, and obtain a clear and transparent solution. Then add 0.20 gram of acrylic acid to the solution, and add 0.1 mol / L of ascorbic acid solution and 0.5 mL of hydrogen peroxide solution into the reactor under stirring condition as initiator. After reacting at 35° C. for 2 hours, a milky white hydroxypropyl cellulose-polyacrylic acid nanoparticle aqueous phase dispersion was obtained. In a 100mL beaker, 0.20 g of monomer N-isopropylacrylamide, 0.15 g of cross-linking agent N,N'-methylenebisacrylamide, and 0.10 g of surfactant sodium lauryl sulfate were blended and Dissolve in 15mL of distilled water and stir at room temperature to dissolve completely to obtain N-isopropylacrylamide s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses thermosensitive polymeric microcapsules and a preparation method and use thereof. The thermosensitive polymeric microcapsules are microcapsules with a hollow structure, the wall material of the microcapsules is polyacrylic acid-poly(N-isopropylacrylamide), and the average size of the thermosensitive polymeric microcapsules is 80 to 2,000 nanometers; and cellulose ether-polyacrylic acid composite colloid particles serving as templates are polymerized with an N-isopropylacrylamide monomer on the surfaces of the templates, cellulose ether then is removed and thus, the microcapsules are obtained. The thermosensitive polymeric microcapsules can be used as carriers for medicines, particularly carriers for protein medicines and antitumor medicines. In the invention, in the presence of N,N'-methylenebisacrylamide serving as a crosslinking agent, the cellulose ether-polyacrylic acid composite colloid particles serving as the templates are polymerized with the N-isopropylacrylamide monomer on the surfaces of the templates to form thermosensitive polymers, then cellulose ether-polyacrylic acid-poly(N-isopropylacrylamide) composite colloid particles are formed, finally cellulose ether in the cellulose ether-polyacrylic acid-poly(N-isopropylacrylamide) composite colloid particles is removed, and thus, thermosensitive polymeric microcapsules are obtained.

Description

technical field [0001] The invention relates to thermosensitive polymer microcapsules and as a drug carrier. Background technique [0002] In recent years, with the maturity of nanotechnology, the nanobiotechnology formed by infiltrating nanotechnology into the biological field has received more and more attention and applications, and the research on nano drug carriers is the focus and hot spot of nanobiotechnology. Nano-scale drug delivery systems have shown good application prospects in achieving targeted drug delivery, sustained release of drugs, improving the bioavailability of insoluble drugs and peptide drugs, and reducing the toxic and side effects of drugs. one of the research hotspots. Nano drug carrier refers to a new type of carrier with a particle size of 10-1000nm, usually made of natural or synthetic polymer materials. It uses nanoparticles as a drug carrier, wraps drug therapeutic molecules in nanoparticles or adsorbs on its surface, binds targeted molecul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/32B01J13/16A61P35/00
Inventor 陈莹南静娅储富祥王春鹏
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY