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Spongy molecular sieve chitosan compound rapid hemostatic material as well as preparation method and application thereof

A hemostatic material and molecular sieve technology, which can be used in medical preparations with non-active ingredients, pharmaceutical formulations, inorganic non-active ingredients, etc., and can solve the problems of muscle, tissue, nerve burns, low hemostatic efficiency of chitosan, and unfavorable cleaning of wounds. , to achieve the effects of large specific surface area, good adsorption and exchange properties, and mild preparation conditions

Inactive Publication Date: 2011-10-05
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Molecular sieve alone is easy to cause local overheating and burns to the muscles, tissues and nerves of the injured
The hemostatic material solves the shortcomings of molecular sieves that release a large amount of heat during hemostasis, is not conducive to cleaning the wound surface, and has low hemostatic efficiency of chitosan

Method used

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  • Spongy molecular sieve chitosan compound rapid hemostatic material as well as preparation method and application thereof
  • Spongy molecular sieve chitosan compound rapid hemostatic material as well as preparation method and application thereof
  • Spongy molecular sieve chitosan compound rapid hemostatic material as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] For the preparation method of NaA(LTA) molecular sieve, please refer to Jilin University doctoral dissertation "Preparation and Properties of Zeolite Molecular Sieve Membrane", Yin Xiaoju. The obtained product was filtered and washed until the pH was 8, and dried at room temperature.

[0020] The obtained product was prepared according to the mass ratio of molecular sieve: 1mol / L calcium chloride solution: deionized water = 5:18:18, and the pH was adjusted to 11 with sodium hydroxide, and then reflux exchanged in a water bath at 100°C for 1h. After cooling to room temperature, the obtained product was filtered and washed to pH 8. As determined by XRF (PANALYTICAL 4400), a NaA (LTA) molecular sieve with a calcium ion exchange degree of 50±5% was obtained.

Embodiment 2

[0022] Get the calcium ion exchange degree prepared in Example 1 and be 50 ± 5% NaA (LTA) molecular sieve, then according to the mass ratio is molecular sieve: 1mol / L calcium chloride solution: deionized water=5: 18: 18 configuration solution, with Sodium hydroxide was used to adjust the pH to 11, and then refluxed in a water bath at 100°C for 1 hour. After cooling to room temperature, the obtained product was filtered and washed to pH 8. As determined by XRF (PANALYTICAL 4400), a NaA (LTA) molecular sieve with a calcium ion exchange degree of 90±5% was obtained.

Embodiment 3

[0024] For the preparation method of NaX(FAU) molecular sieve, refer to Olson, D.H. Zeolites, 15, 439-443 (1995). The obtained product was filtered and washed until the pH was 8, and dried at room temperature. The obtained product was prepared according to the mass ratio of molecular sieve: 1mol / L calcium chloride solution: deionized water = 5:18:18, and the pH was adjusted to 11 with sodium hydroxide, and then reflux exchanged in a water bath at 100°C for 1h. After cooling to room temperature, the obtained product was filtered and washed to pH 8. As determined by XRF (PANALYTICAL 4400), a NaX (FAU) molecular sieve with a calcium ion exchange degree of 55±2% was obtained.

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Abstract

The invention discloses a spongy molecular sieve chitosan compound rapid hemostatic material as well as a preparation method and application thereof, belonging to the technical field of hemostatic dressings, and particularly relating to a spongy molecular sieve chitosan compound material for rapid hemostasis as well as a preparation method and application thereof to preparation of hemostatic patches, hemostatic sponges, hemostatic bandages and medicament release carriers. The hemostatic material is a mixture of a molecular sieve and chitosan in the ratio of 1:1-1:3, wherein the molecular sieve is an FAU, LTA, VPI-5 or ALPO-5 type molecular sieve material for exchanging Ca<+> and Ag<+>; the total exchanging degree of the Ca<+> and the Ag<+> is 50-95 percent; and the exchanging degree of silver ions is 0-40 percent. Due to the adoption of the hemostatic material prepared with the method, the defects such as large thermal discharge of the molecular sieve during hemostasis, an adverse effect on cleaning a wounded area and low hemostasis efficiency of chitosan are overcome.

Description

technical field [0001] The invention belongs to the technical field of hemostatic dressings, and in particular relates to a spongy molecular sieve chitosan composite material for rapid hemostasis, a preparation method and its use in the preparation of hemostatic patches, hemostatic sponges, hemostatic bandages and drug slow-release carriers. Background technique [0002] Surgery can cause bleeding in the human body, and uncontrolled bleeding is an important cause of death. The data show that when a blood loss exceeds 20% of the total blood volume, symptoms such as rapid pulse, blood pressure drop, and shock will appear; Life is in danger. Usually, under the condition that the self-coagulation function of human blood is normal, superficial bleeding and venous bleeding can self-coagulate. However, in arterial bleeding or in some surgical procedures where blood anticoagulants are used, the blood cannot coagulate itself. In this case, special hemostatic equipment and materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61K47/36A61K47/02
Inventor 郑维佳贾飞王卓鹏温强郭嵩李云蹊陈炳鹏董晓明王金成于吉红
Owner JILIN UNIV
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