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Method for preparing bioactive calcium phosphate coating on magnesium alloy surface for endosseous implant

A bioactive calcium and magnesium alloy technology, applied in metal material coating technology, coating, medical science, etc., can solve problems such as uneven distribution of Ca-P coating and uneven distribution of white deposits on the surface of magnesium alloys , to achieve the effect of low cost, easy operation and improved biological activity

Active Publication Date: 2011-10-05
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, the white deposits on the surface of the magnesium alloy after the pre-calcium adsorption treatment are unevenly distributed, resulting in uneven distribution of the Ca-P coating.

Method used

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  • Method for preparing bioactive calcium phosphate coating on magnesium alloy surface for endosseous implant
  • Method for preparing bioactive calcium phosphate coating on magnesium alloy surface for endosseous implant
  • Method for preparing bioactive calcium phosphate coating on magnesium alloy surface for endosseous implant

Examples

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Effect test

Embodiment 1

[0028] A bioactive Ca-P coating was prepared on the surface of AZ31 (Mg-Al series) alloy. Firstly, the AZ31 magnesium alloy is made into The samples were polished with 320-mesh water sandpaper and No. 3 metallographic sandpaper in turn. Ultrasonic cleaning with absolute ethanol for 10 min, and air-dried. The sample was soaked in a 20% HF solution in a water bath at a constant temperature (20°C) for 4 hours, washed with deionized water and absolute ethanol successively, and dried. Then put the sample into NaNO 3 : Ca 3 (PO 4 ) 2 :H 2 o 2 = 7:4:2 (wt%) solution soaked in a water bath at a constant temperature (20°C) for 8h. The scanning electron microscope observed that the thickness of the chemical conversion film was 150nm, and the composition analysis showed that the chemical conversion film was MgF 2 , it was observed that the thickness of the Ca-P coating was 10 μm, and the atomic ratio of Ca / P was 1:1. It shows that the prepared Ca-P surface coating has good bio...

Embodiment 2

[0030] A bioactive Ca-P coating was prepared on the surface of NZ30K (Mg-RE series) alloy. Firstly, the NZ30K magnesium alloy is made into The samples were polished with 320-mesh water sandpaper and No. 3 metallographic sandpaper in turn. Ultrasonic cleaning with absolute ethanol for 10 min, and air-dried. The sample was soaked in a 60% HF solution in a water bath at a constant temperature (20°C) for 16 hours, washed with deionized water and absolute ethanol successively, and dried. Then put the sample into NaNO 3 :Na 3 PO 4 : Ca(H 2 PO 4 ) 2 :H 2 o 2 = 2: 2: 5: 1 (wt%) soaking in a water bath at a constant temperature (20° C.) for 48 hours. The thickness of the chemical conversion film was 2 μm observed by the scanning electron microscope, and the composition analysis showed that the chemical conversion film was MgF2. It was observed that the thickness of the Ca-P coating was 20 μm, and the atomic ratio of Ca / P was 1.05:1, indicating that the surface has good biolog...

Embodiment 3

[0034] A bioactive Ca-P coating was prepared on the surface of WE43 (Mg-RE series) alloy. Firstly, the WE43 magnesium alloy is made into The samples were polished with 320-mesh water sandpaper and No. 3 metallographic sandpaper in turn. Ultrasonic cleaning with absolute ethanol for 10 min, and air-dried. The sample was soaked in a 40% HF solution in a water bath at a constant temperature (20°C) for 8 hours, washed with deionized water and absolute ethanol successively, and dried. Then put the sample into NaNO 3 : Ca 3 (PO 4 ) 2 : Ca(H 2 PO 4 ) 2 ·H 2 O:H 2 o 2 =5:1:2:1 (wt%) soaking in a water bath at a constant temperature (20° C.) for 24 hours. The scanning electron microscope observed that the thickness of the chemical conversion film was 600nm, and the composition analysis showed that the chemical conversion film was MgF 2 , it was observed that the thickness of the Ca-P coating was 30 μm, and the atomic ratio of Ca / P was 1.1:1. It shows that the obtained Ca...

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Abstract

The invention belongs to the technical field of medical material, and relates to a method for preparing a bioactive calcium phosphate coating on a magnesium alloy surface for an endosseous implant. The method comprises: sequential soaking the magnesium alloy surface layer for the endosseous implant in hydrofluoric acid and a mixed solution containing phosphate at a constant temperature to preparethe bioactive calcium phosphate coating. With adopting a chemical deposition method provided by the present invention, surface bioactivity of the magnesium alloy is improved, and corrosion rate of the magnesium alloy substrate is reduced. The method has simple operation process, easy operation and no requirement of special equipment. The bioactive calcium phosphate coating prepared by the method has strong combining power with the magnesium alloy substrate, and has controllable thickness.

Description

technical field [0001] The invention relates to a method for preparing a surface coating in the technical field of medical materials, in particular to a method for preparing a bioactive calcium-phosphorus coating on a magnesium alloy surface layer for bone implants. Background technique [0002] Compared with other medical metal materials, magnesium alloy has the following advantages: 1) Degradability. Magnesium alloys have a low corrosion potential, and are prone to corrosion in an in vivo environment containing chloride ions, and are completely degraded in the body in a slow corrosion manner, which can realize the degradation and absorption of magnesium in the human body. 2) High biological safety. As an essential nutrient element for the human body, Mg ranks fourth in the human body after Ca, K, and Na. At present, many developed countries have listed magnesium as an essential element for the human body, and the importance of magnesium supplementation is no less than th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/36A61L27/32A61L27/04
Inventor 袁广银李治国牛佳林章晓波丁文江
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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