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Multi-layer hernia repairing patch and preparation method thereof

A technique for hernia repair and patch, applied in the field of multilayer hernia patch and its preparation, which can solve the problems of cumbersome preparation process, many chemical reactions, poor softness, etc., and achieve simple process, firm combination, and good anti-adhesion Effect

Active Publication Date: 2011-10-19
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of this product has gone through many chemical reactions, which is relatively complicated and adds a large cost to the production process.
[0008] The above products may have problems such as cumbersome preparation process, many chemical reactions, easy delamination, poor softness and controversial anti-adhesion effect, and the price is very expensive

Method used

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  • Multi-layer hernia repairing patch and preparation method thereof
  • Multi-layer hernia repairing patch and preparation method thereof
  • Multi-layer hernia repairing patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The configuration mass fraction is the PLCL acetone solution of 10%, pours on the polypropylene (PP) mesh that is placed in the mould, smears evenly, ventilates and volatilizes solvent, obtains PP / PLCL composite mesh, PLCL film is on the polypropylene mesh One side forms a polyester layer.

[0034] The mesh was placed in a vessel containing evenly spaced grooves filled with PLCL acetone. After partial dissolution, the patch is taken out to obtain a PP / PLCL composite mesh with a PLCL layer in a uniform void area. Preferably, the ratio of the area of ​​the void area of ​​the obtained PLCL layer to the area of ​​the mesh sheet is 10%-80%, preferably 30%, 40%, 50% or 60%.

[0035]Pour the collagen solution with a mass fraction of 2% into a mold with a depth of 1 mm, and freeze-dry to obtain a spongy collagen film layer with a thickness of 1 mm;

[0036] Configure PLCL acetone solution with a mass fraction of 5%, take 25mL and pour it on 250cm 2 Spread the spongy collagen...

Embodiment 2

[0040] Configuration mass fraction is 10% PLCL chloroform solution, casts on the polypropylene (PP) mesh that is placed in the mould, smears evenly, ventilates and volatilizes solvent, obtains PP / PLCL composite mesh, and PLCL film is on the polypropylene mesh one side of the cambium.

[0041] The mesh was placed in a vessel containing evenly spaced grooves filled with chloroform. After partial dissolution, the patch is taken out to obtain a PP / PLCL composite mesh with a PLCL layer in a uniform void area. The ratio of the area of ​​the void area of ​​the obtained PLCL layer to the area of ​​the mesh sheet is 10%-80%, preferably 30%, 40%, 50% or 60%.

[0042] Pour a hyaluronic acid solution with a mass fraction of 1% (crosslinked by EDC and NHS, the same below) into a mold with a depth of 2 mm, and freeze-dry to obtain a hyaluronic acid sponge with a thickness of 2 mm.

[0043] Configure a PLCL chloroform solution with a mass fraction of 5%, take 25mL and pour it on 250cm 2 S...

Embodiment 3

[0046] Configuration mass fraction is 10% PLGA tetrahydrofuran solution, casts on the polypropylene (PP) mesh that is placed in the mould, smears evenly, ventilates and volatilizes solvent, obtains PP / PLGA composite mesh, PLGA film is on the polypropylene mesh One side cambium.

[0047] The mesh was placed in a vessel containing evenly distributed grooves in which PLGA tetrahydrofuran was placed. After partial dissolution, the patch is taken out to obtain a PP / PLGA composite mesh with a PLGA layer in a uniform void area. The ratio of the area of ​​the void area of ​​the obtained PLGA layer to the area of ​​the mesh sheet is 10%-80%, preferably 30%, 40%, 50% or 60%.

[0048] A hyaluronic acid solution with a mass fraction of 1% (crosslinked by EDC and NHS, the same below) was poured into a mold with a depth of 2 mm, and freeze-dried to obtain a hyaluronic acid sponge with a thickness of 2 mm.

[0049] Configure a PLGA tetrahydrofuran solution with a mass fraction of 5%, take ...

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Abstract

The invention provides a multi-layer hernia repairing patch which comprises a nondegradable polymer mesh panel and a polymeric membrane layer manufactured by biocompatible natural high polymer materials. The nondegradable polymer mesh panel and the polymeric membrane layer are combined together by a degradable polyester interlayer. The invention also provides a multi-layer hernia repairing patch preparation method, which comprises the steps as follows: firstly, a polyester solution is prepared; secondarily, the polyester solution is poured on the nondegradable polymer mesh panel to obtain a composite mesh panel with a polyester layer on a single side after volatilization and then a composite mesh panel comprising uniform gap areas is obtained after the polyester layer is partially dissolved; thirdly, the polymeric membrane layer manufactured by the biocompatible natural high polymer materials is obtained; fourthly, the polymeric membrane layer is paved on the polyester solution to obtain a composite membrane with a polyester layer on a single side after volatilization; and fifthly, the polyester layer of the composite mesh panel and the polyester layer of the composite membrane are opposite to each other and are thermally pressed into a whole body, thereby forming the multi-layer hernia repairing patch. As the multiple layers of the multi-layer hernia repairing patch are combined firmly, the multi-layer hernia repairing patch can be used for implantation in enterocoelia, can realize the function of strengthening weak or defected tissues, and meanwhile, can reduce the sticking risk between a viscera and the nondegradable polymer mesh panel.

Description

technical field [0001] The invention relates to a multi-layer hernia repair sheet for intraperitoneal implantation and a preparation method thereof. Background technique [0002] Currently commonly used hernia repair sheets are polyester mesh (such as Dacron, Mersilene) and polypropylene mesh (such as Marlex, Prolene, etc.). However, pure non-degradable mesh cannot be used for intraperitoneal implantation, because organs may adhere to the mesh and cause serious complications, such as infertility, chronic pelvic pain, intestinal fistula, intestinal obstruction, etc. [0003] A common solution is to insert physical barriers between locations where adhesions are not desired. However, this barrier leads to problems with the interconnection of the barrier, because if the barrier is made of a non-absorbent material, it is itself a source of adhesion; if it is absorbable, the absorption must be non-inflammatory so as not to cause self-adhesion . [0004] The ePTFE developed by G...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/44A61L27/16A61L27/18A61L27/20A61L27/22A61L27/24
Inventor 孙杰孙陆军许松玲
Owner TRANSEASY MEDICAL TECH
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