Application of extractive of adinandra nitida leaves in preparation of anti-inflammatory analgesia medicament

A bright leaf and extract technology, applied in the field of medicine, can solve the problem of no anti-inflammatory and analgesic effect, etc., and achieve the effect of good therapeutic effect and low toxicity
CN102218103BActive Publication Date: 2013-07-17玉林市中医医院
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
玉林市中医医院
Publication Date
2013-07-17

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Abstract

The invention belongs to the technical field of medical treatment, and in particular relates to application of an extractive of adinandra nitida leaves to the preparation of an anti-inflammatory analgesia medicament. The toxicity and the anti-inflammatory analgesia pharmacodynamics evaluation are carried out on ethyl acetate parts of the adinandra nitida leaves by taking a mice acute toxicity test as a medicine toxicity index, taking a mice hot-plate test and a rat toe mechanical stabbing pain test as analgesia pharmacodynamics indexes, taking a test on the glacial acetic acid-induced capillary permeability hyperfunction of mice peritoneal cavities, a test on the dimethylbenzene-induced swelling of mice ears and a test on the cotton balling granulation of rats as anti-inflammatory pharmacodynamics indexes. The results show that the extractive has the advantages of low toxicity and very good anti-inflammatory analgesia activity and can be applied to the preparation of anti-inflammatoryanalgesia medicaments or auxiliary medicaments.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of effective components of poplar leaves, especially the application of the ethyl acetate part of poplar leaves in the preparation of anti-inflammatory and analgesic drugs. Background technique

[0002] Inflammation is a defense-based reaction of living tissue to various injury factors. The clinical features are redness, swelling, heat, and pain. It is the response of inflammatory factors to stimulate living tissue with vascular system to local damage. The pathological process is generally divided into early capillary hyperpermeability, exudation of vascular contents, edema, and late connective tissue hyperplasia and granuloma formation; pain refers to the somatic sensation associated with tissue damage and potential tissue damage. Or when injured, the injured part releases pain-causing substances such as bradykinin, histamine, serotonin, PG, etc., which stimulat...

Claims

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