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Quality control method for traditional Chinese medicine composition for treating infantile indigestion with food retention

A quality control method and technology for children's food product, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as difficult preparation quality control, and achieve the effect of effective product quality and high stability.

Inactive Publication Date: 2011-11-02
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some deficiencies in the current quality control methods of Qianqu, making it difficult to carry out more effective quality control on the preparation

Method used

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  • Quality control method for traditional Chinese medicine composition for treating infantile indigestion with food retention
  • Quality control method for traditional Chinese medicine composition for treating infantile indigestion with food retention
  • Quality control method for traditional Chinese medicine composition for treating infantile indigestion with food retention

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Investigation on TLC identification method of rhubarb.

[0025] Rhubarb mainly contains anthraquinone compounds, including rhein, emodin, chrysophanol, aloe-emodin, emodin methyl ether, etc. According to the experiment, negative and no interference, the method is as follows.

[0026]Thin layer plate: silica gel G plate prepared by 0.5% sodium carboxymethyl cellulose solution, the thickness is 500mm.

[0027] Preparation of the test solution: Emodin is an anthraquinone component, which exists in the form of aglycone and glycoside in medicinal materials, so it is selected to extract with methanol first, then hydrolyzed with hydrochloric acid and then extracted with ethyl acetate. The result is better, so this is selected. method.

[0028] Selection of adsorbent: silica gel G plate with sodium carboxymethyl cellulose as binder for separation, the results showed that the separation was good, so silica gel G plate with sodium carboxymethyl cellulose as binder w...

Embodiment 2

[0031] Example 2: Investigation on TLC identification method of woody fragrance.

[0032] The main chemical components of coriander are dehydrocorylides and amino acids. According to the experiment, negative and no interference, the method is as follows.

[0033] Thin layer plate: silica gel G plate prepared by 0.5% sodium carboxymethyl cellulose solution, the thickness is 500mm.

[0034] Preparation of the test solution: Dehydrocressin is a sesquiterpene component and is a fat-soluble component. Therefore, in order to reduce the interference of impurities, it was extracted with petroleum ether (30~60°C) and neutralized after extraction with ethyl acetate. Alumina column was used to prepare the test solution for experiment, and the result of the latter was better without interference, so ethyl acetate was selected for extraction.

[0035] Selection of adsorbent: silica gel G plate with sodium carboxymethyl cellulose as binder for separation, the results showed that the s...

Embodiment 3

[0038] Example 3: TLC identification of synephrine in Citrus aurantium medicinal material.

[0039] The main components of Citrus aurantium are flavonoids, alkaloids and volatile oils. According to the experiment, negative and no interference, the method is as follows.

[0040] Preparation of the test solution: because synephrine is an alkaloid component, it is easily soluble in water. Therefore, refer to the preparation method of the test solution under the determination of the content of the Chinese Pharmacopoeia Citrus aurantium medicinal material, use methanol to extract, evaporate to dryness, and the residue water The solution was passed through a polyamide column, then eluted with water, all collected and evaporated to dryness, and the residue was dissolved in methanol as the test solution for experiments. The results were good, so this method was selected.

[0041] The choice of adsorbent: the silica gel G plate with sodium carboxymethyl cellulose as the binder was s...

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Abstract

The invention provides a quality control method for a traditional Chinese medicine composition for treating infantile indigestion with food retention, relating to a quality control method for traditional Chinese medicine compositions. The quality control method comprises one or more of the following methods: 1, a test article prepared in the invention and an emodin comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison; 2, a test article prepared in the invention and a dehydrocostuslactone comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison; and 3, a test article prepared in the invention and a synephrine comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison. According to the quality control method provided by the invention, the components for identifying medicinal materials and assaying are selected by screening the medicinal materials, thus effectively controlling the product quality and obtaining higher accuracy, sensitivity and stability of the method.

Description

technical field [0001] The invention relates to a quality control method of a traditional Chinese medicine composition, in particular to a quality control method of Qianqu. Background technique [0002] Indigestion is a common symptom in children. In addition to diet control, indigestion in children can be treated with medicines that dissolve indigestion. Digestive medicine has the effects of digesting food and eliminating accumulation, invigorating the spleen and appetizing, and harmonizing the spleen. There is an important class of traditional compound preparation koji drugs in digestion medicine. The representative of koji medicine is Liushenqu. Liushenqu is made of Artemisia annua, cocklebur, Polygonum spicosa, red bean, almond, wheat bran and flour, which has the effect of digestion and stomach. [0003] Qianqu is composed of patchouli, radish (stir-fried), green bark, morning glory, tuckahoe, citrus aurantium (stir-fried), licorice, Rhizoma Cyperi (stir-fried with vi...

Claims

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Application Information

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IPC IPC(8): A61K36/8998G01N30/02G01N30/90A61P1/14
Inventor 肖军平康兴东吴永忠李旭余显英张荷英
Owner JIANGXI POZIN PHARMA
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