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A biodegradable magnesium-based orthopedic implant biomedical material and preparation method thereof

A biomedical material and orthopaedic technology, applied in medical science, prosthesis, etc., can solve the problems that pure magnesium is difficult to meet the mechanical conditions of implant materials, difficult to apply for clinical use of the US FDA, lack of international evaluation standards, etc., and achieve metabolic pathway. Clear, non-toxic and side effects, eliminating the effect of primary battery corrosion

Inactive Publication Date: 2011-11-30
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(4) The degradation method of degradable polymers in the body is bulk degradation, and the strength of the material will suddenly and greatly decrease during the degradation process
[0004] As a new type of medical implant material, magnesium alloy mainly has the following problems to be solved [A. Purnama et, al. Acta Biomaterialia, 6 (2010) 1800 -1807. F. Witte et.al, Current Opinion in Solid State and Materials Science, 12 63-72.]: (1) Low mechanical properties, pure magnesium is difficult to meet the mechanical conditions required for implant materials
(2) The corrosion resistance is poor, and hydrogen gas is precipitated too quickly, which is easy to form bulges and cause inflammation
(3) The potential toxicity of the degradation products of the current alloy cannot be evaluated, and the controversy is relatively large
(4) The lack of international evaluation standards makes it difficult to apply for clinical use in the US FDA

Method used

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  • A biodegradable magnesium-based orthopedic implant biomedical material and preparation method thereof
  • A biodegradable magnesium-based orthopedic implant biomedical material and preparation method thereof
  • A biodegradable magnesium-based orthopedic implant biomedical material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 30 grams of Zn grains with a mass purity of 99.99%, 1 g of Ca grains, and 20 grams of Ag grains, all of which have a particle size of 200 mesh; the remainder is Mg ingots with a mass purity of 99.9%, and remove the surface scale of the Mg ingots. All added raw materials were preheated at 400°C for 90 minutes, metal Mg ingots, Zn grains, Ca grains, and Ag grains were added in sequence to a tantalum crucible at 770°C, protected by a 1:15 mixture of sulfur hexafluoride and argon, and prepared Alloy ingot; each time a raw material is added, stir for 30 minutes. After all the raw materials are added, stir for 50 minutes and stop heating. The alloy liquid is poured into the steel mold at 770°C, and the steel mold is fully preheated at 700°C. After pouring, it is kept in a resistance furnace for 60 minutes, and then cooled to room temperature with water to obtain the composition: Mg-3Zn-0.1Ca-2Ag (wt.%) 1000 g alloy ingot; the above alloy ingot was preheated at 200°C for ...

Embodiment 2

[0024] Take 1 g of Zn grains with a mass purity of 99.99%, 30 g of Ca grains, and 0.1 g of Ag grains, all of which have a particle size of 200 mesh, and the remainder is Mg ingots with a mass purity of 99.9%, and remove the surface scale of the Mg ingots. After all the added raw materials were preheated at 200°C for 30 minutes, metal Mg ingots, Zn grains, Ca grains, and Ag grains were added to the tantalum crucible at 770°C in sequence. Prepare the alloy ingot under the protection of a 1:12 mixture of sulfur hexafluoride and argon; each time a raw material is added, stir for 10 minutes, after all the raw materials are added, fully stir for 20 minutes, and pour it into a steel mold at 700 ° C. The steel mold was preheated at 600 °C, and after pouring, it was kept in a resistance furnace for 30 minutes, and then cooled to room temperature with water to obtain a 1000 g alloy ingot with the composition: Mg-0.1Zn-3Ca-0.01Ag (wt.%); the above The alloy ingot was preheated at 400°C f...

Embodiment 3

[0028]Take 10 grams of Zn grains with a mass purity of 99.99%, 20 grams of Ca grains, and 10 grams of Ag grains, all of which have a particle size of 200 mesh, and the balance is Mg ingots with a mass purity of 99.9%, and remove the surface scale of the Mg ingots. After all the added raw materials were preheated at 300°C for 50 minutes, metal Mg ingots, Zn grains, Ca grains, and Ag grains were added to the tantalum crucible at 770°C in sequence. Prepare the alloy ingot under the protection of a mixed gas of sulfur hexafluoride and argon at a ratio of 1:10; stir for 25 minutes each time a raw material is added, and fully stir for 40 minutes after all the raw materials are added, and pour it into a steel mold at 720 ° C. The steel mold was preheated at 650 °C, and after pouring, it was kept in a resistance furnace for 50 minutes, and then cooled to room temperature with water to obtain a 1000 g alloy ingot with the composition: Mg-1Zn-2Ca-1Ag (wt.%); the above alloy ingot Prehea...

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Abstract

The invention relates to a degradable magnesium-base biomedical material for implantation in orthopaedics. The chemical component of the biomedical material is Mg-xZn-yCa-zAg, wherein x, y and z are percentages by weight (wt.%), and meet 0.1% <= x <= 3.0%, 0.1% <= y <= 3.0%, and 0.01% <= z <= 2.0%. The preparation method of the biomedical material comprises the following steps of: sequentially adding preheated metal Mg ingot, Zn particles, Ca particles and Ag particles to a resistance furnace, heating, smelting and pouring to obtain alloy ingot under mixed gas shield of sulfur hexafluoride and argon gas, then hammering in shielding gas, and finally performing reverse-phase extrusion to obtain an implanted device. The degradable magnesium-base biomedical material for implantation in orthopaedics has an average breaking strength exceeding 180MPa at room temperature, an average yield strength exceeding 120MPa, an average elongation exceeding 22%, and an elastic modulus of about 47Gpa; the alloyed elements are uniformly distributed in the substrate and have good corrosion resistance and excellent biocompatibility; and the biomedical material is suitable for repairing osseous tissue and preparing a moderately stressed implanted device in orthopaedics.

Description

technical field [0001] The invention relates to a medical material and a preparation method, in particular to an orthopedic medical material and a preparation method. Background technique [0002] Features and advantages of magnesium alloys as new biomedical materials [M.P. Staiger, A.M. Pietak, J. Huadmai, G. Dias, Biomaterials, 27 (2006) 1728-1734.]: (1) Magnesium alloys are biodegradable metal implant materials , can fully realize the degradation and absorption in the body, avoiding the pain and burden of secondary surgery, and compared with the currently developed absorbable intraosseous implant materials (degradable polymers, absorbable bioceramics), magnesium alloy has better strength and plasticity, and closer to the elastic modulus and density of bone tissue. Compared with existing non-degradable metal materials, its elastic modulus is also closer to bone tissue. (2) Magnesium is an essential element in the human body and plays a variety of important roles in the h...

Claims

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Application Information

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IPC IPC(8): A61L27/06C22C23/00C22C23/04C22C1/02C22F1/06
Inventor 彭秋明赵翠玲李慧
Owner YANSHAN UNIV
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