A raw material pretreatment method for improving the dissolution rate of active ingredients of medicinal plants

Abstract

The invention discloses a raw material gas explosion pretreatment method for improving the dissolution rate of active ingredients of medicinal plants. The method comprises the following steps of: putting materials preimpregnated in water or aqueous solution into a high-pressure container, sealing, introducing a medium, keeping the temperature between 40 and 250 DEG C for 0.5 to 30 minutes, releasing pressure quickly, and discharging the materials in the high-pressure container to a normal-pressure container to obtain materials which are subjected to gas explosion pretreatment, wherein the medium is one or a combination of two of air, carbon dioxide, ozone, liquid nitrogen, nitrogen, water vapor and supercritical CO2. On the basis of the bioactivity of the active ingredients of the medicinal plants, various medium combination gas explosion modes in the low-temperature and high-pressure state are adopted selectively to ensure the treatment strength of the materials, and the dissolution rate of the active ingredients is improved on the premise that the active ingredients are not damaged to improve the utilization rate of raw materials; and the method is quick, simple, economic, high in adaptation degree and wide in selective range, and pollution is avoided, so the method is a significant path for realizing high-value utilization of the medicinal plants.

Description

technical field

[0001] The invention belongs to the application field of medicinal plants, in particular to a raw material pretreatment method for improving the dissolution rate of active ingredients of medicinal plants. Background technique

[0002] Under the influence of population aging, global medical system reform, health care and the world trend of "returning to nature", the application scope and usage rate of traditional medicine in the world are constantly increasing, and the space in the international market is constantly expanding, showing worldwide It has a good development opportunity and a very broad development prospect. According to the estimates of the World Health Organization, 80% of the world's population is currently using or has used various traditional medicines for treatment and health care, and traditional medicines generally use medicinal plants as the main materials. Medicinal plants are the general term for plants that contain substances with cert...

Examples

Embodiment 1

[0023] Example 1: Extracting amygdalin from bitter almonds by gas explosion

[0024] Add bitter almonds, a medicinal plant rich in fats and oils, to water at a ratio of 1:1 of dry medicinal materials to water, and then soak them at room temperature for 30 minutes; place the soaked materials in a steam explosion tank, and put them into Air to make the temperature in the tank reach 100°C, keep it for 5 minutes, and then carry out steam explosion treatment; collect the materials after steam explosion, extract amygdalin in bitter almonds before and after steam explosion, and use silver nitrate titration method to determine the content of bitter almonds, after steam explosion The amygdalin extraction rate of the material is 15.32% higher than that of the unexploded material.

Embodiment 2

[0025] Example 2: Gas explosion treatment for the extraction of chlorinated limpetine

[0026] Chop the double-sided needle medicinal material into 3-5cm pieces, add water according to the ratio of 1:1 of the absolute dry medicinal material and water, and then soak at room temperature for 60 minutes; put the soaked material in the steam explosion tank , put in water vapor to make the temperature in the tank reach 200°C, keep it for 5 minutes, and then carry out steam explosion treatment; add an organic solvent 6 times its dry weight to the material after steam explosion treatment, and extract 3 times under boiling state, each time 3.0h , combined the extracts; the extracts were evaporated under reduced pressure to obtain a precipitate, which was mixed with HCl solution of pH 2, extracted with ethyl acetate to remove non-alkaline components, and then the aqueous phase was adjusted to pH 10 with NaOH, while Precipitation is generated, remove the precipitate and extract the remai...

Embodiment 3

[0027] Example 3: Chlorogenic acid extracted from leaves of Eucommia ulmoides treated by gas explosion

[0028]Get 500g of eucommia leaf medicinal material, add acetic acid water (the ratio of acetic acid to water is 1:100) to eucommia leaf medicinal material according to the ratio of dry medicinal material and acetic acid water quality 1:2, then soak at normal temperature for 60min; The final material is placed in the steam explosion tank, and carbon dioxide is introduced to make the temperature in the tank reach 80°C, and the steam explosion treatment is carried out after maintaining for 15 minutes; the material after steam explosion treatment or the conventionally crushed material to 40 mesh is added to 5 times its absolute dry weight extracted water at 40°C for 3 times, each time for 50 min, and combined the extracts; concentrated the extracts under reduced pressure, added 3 times more ethyl acetate to the concentrated solution and extracted twice to obtain an ethyl acetate...

technical field

[0001] The invention belongs to the application field of medicinal plants, in particular to a raw material pretreatment method for improving the dissolution rate of active ingredients of medicinal plants. Background technique

[0002] Under the influence of population aging, global medical system reform, health care and the world trend of "returning to nature", the application scope and usage rate of traditional medicine in the world are constantly increasing, and the space in the international market is constantly expanding, showing worldwide It has a good development opportunity and a very broad development prospect. According to the estimates of the World Health Organization, 80% of the world's population is currently using or has used various traditional medicines for treatment and health care, and traditional medicines generally use medicinal plants as the main materials. Medicinal plants are the general term for plants that contain substances with cert...

Examples

Embodiment 1

[0023] Example 1: Extracting amygdalin from bitter almonds by gas explosion

[0024] Add bitter almonds, a medicinal plant rich in fats and oils, to water at a ratio of 1:1 of dry medicinal materials to water, and then soak them at room temperature for 30 minutes; place the soaked materials in a steam explosion tank, and put them into Air to make the temperature in the tank reach 100°C, keep it for 5 minutes, and then carry out steam explosion treatment; collect the materials after steam explosion, extract amygdalin in bitter almonds before and after steam explosion, and use silver nitrate titration method to determine the content of bitter almonds, after steam explosion The amygdalin extraction rate of the material is 15.32% higher than that of the unexploded material.

Embodiment 2

[0025] Example 2: Gas explosion treatment for the extraction of chlorinated limpetine

[0026] Chop the double-sided needle medicinal material into 3-5cm pieces, add water according to the ratio of 1:1 of the absolute dry medicinal material and water, and then soak at room temperature for 60 minutes; put the soaked material in the steam explosion tank , put in water vapor to make the temperature in the tank reach 200°C, keep it for 5 minutes, and then carry out steam explosion treatment; add an organic solvent 6 times its dry weight to the material after steam explosion treatment, and extract 3 times under boiling state, each time 3.0h , combined the extracts; the extracts were evaporated under reduced pressure to obtain a precipitate, which was mixed with HCl solution of pH 2, extracted with ethyl acetate to remove non-alkaline components, and then the aqueous phase was adjusted to pH 10 with NaOH, while Precipitation is generated, remove the precipitate and extract the remai...

Embodiment 3

[0027] Example 3: Chlorogenic acid extracted from leaves of Eucommia ulmoides treated by gas explosion

[0028]Get 500g of eucommia leaf medicinal material, add acetic acid water (the ratio of acetic acid to water is 1:100) to eucommia leaf medicinal material according to the ratio of dry medicinal material and acetic acid water quality 1:2, then soak at normal temperature for 60min; The final material is placed in the steam explosion tank, and carbon dioxide is introduced to make the temperature in the tank reach 80°C, and the steam explosion treatment is carried out after maintaining for 15 minutes; the material after steam explosion treatment or the conventionally crushed material to 40 mesh is added to 5 times its absolute dry weight extracted water at 40°C for 3 times, each time for 50 min, and combined the extracts; concentrated the extracts under reduced pressure, added 3 times more ethyl acetate to the concentrated solution and extracted twice to obtain an ethyl acetate...