A kind of roxithromycin nanoemulsion antibacterial drug and preparation method thereof
A technology of roxithromycin and antibacterial drugs, which is applied in the field of veterinary medicine, can solve the problems of being unable to cover up the bitter taste of roxithromycin, unsatisfactory therapeutic effect, and unsatisfactory absorption, so as to achieve improved bioavailability, low toxicity, and slow good release effect
Inactive Publication Date: 2011-12-21
NORTHWEST A & F UNIV
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AI Technical Summary
Problems solved by technology
Some of these oral dosage forms cannot cover the bitter taste of roxithromycin. In addition, the particle size of the drug is too large, and the absorption after oral administration is not ideal and incomplete; the sustained-release dosage form has the effect of sustained release, but the manufacturing process is complicated. Too much material and high cost
The efficacy of roxithromycin without coating measures will be reduced in the acidic environment of the stomach, and the therapeutic effect is not ideal
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0050] 1) Add 0.001 g of roxithromycin into the mixed solution of Tween-20 40g, EL-40 2g and absolute ethanol 18g and stir until completely dissolved;
[0051] 2) Add 10g of ethyl acetate into the solution prepared in step 1) and stir evenly;
[0052] 3) Slowly add 29.999 g of distilled water to the solution prepared in step 2) at room temperature, and stir while adding, until a transparent, clear, colorless or yellow liquid with low viscosity and good fluidity is formed.
Embodiment 2
[0054] Roxithromycin 0.01g, absolute ethanol 1.0g, ethyl acetate 1.0g, RH-40 8.0g, distilled water 9.99g.
Embodiment 3
[0056] Roxithromycin 0.2g, absolute ethanol 1.5g, ethyl acetate 1.0g, Tween-80 7.5g, distilled water 9.75g.
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Abstract
The invention discloses a roxithromycin nano-emulsion antibacterial drug, which has a particle diameter of 1-100 nm and is composed of the following raw materials in mass percentage: 0.001%-5% of roxithromycin, a surfactant and a co-surfactant 20% to 60%, oil 2.2% to 26.7%, and distilled water as the balance. The sum of the mass percentages of the above raw materials is 100%. The appearance of the drug is light yellow, clear and transparent liquid, which has the characteristics of low viscosity, good stability, strong dispersibility, rapid absorption, etc., and can improve the bioavailability of the drug, prolong the half-life of the drug in the body, enhance the curative effect, and reduce the toxicity , and has sustained-release and targeting effects, and at the same time has the advantages of simple preparation process, low energy consumption, low toxicity, high safety, and mass production without special equipment.
Description
Technical field [0001] The invention is a veterinary drug, involving a new dosage form for antibacterial drugs, and specially involves a kind of nanomidicin nanocystal antibacterial drugs and its preparation methods. Background technique [0002] Robeee is a large -ringed antibiotic, which is a positive bacteria, including Gramoplain, including Golden Pyrobacteria, Peribies, Epidermiococcus, Pneumonia, and some Gram -negative bacteria and anaerobic bacteria.The chlamydia and the Legion bacteria have strong antibacterial activity.It can be used to treat the upper and lower respiratory tract infection of livestock and poultry by biococcus bacteria, hemolytic splitteriococcus, hemobacteria, mycoplasma, chlamydia, and army bacteria; ophthalmuliditis, oral infection, urinary tract and genital infection caused by chlamydia; Skin infection caused by Staphylococcus or Staphylococcus.Antibacterial spectrum is wide.However, due to the insoluble water in this type of drug, the current dosag...
Claims
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Login to View More IPC IPC(8): A61K9/107A61K31/7048A61K47/44A61K47/26A61P31/04
Inventor 欧阳五庆兰莹吴小利
Owner NORTHWEST A & F UNIV