Method for extracting scopoletin from artemisia annua residues
A technology of scopoletin and Artemisia annua, which is applied in the field of extracting scopoletin, can solve the problems of immature and perfect industrial extraction methods, and achieve the effects of saving investment, high purity and simple operation
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Embodiment 1
[0016] Add 900kg of Artemisia annua residue into the extraction tank at one time, then add a total of 16000L of acetone (analytical pure) to the extraction tank, add in four times, each addition is 4000L, each time at 53°C and 0.06MP steam After depressing and reflux extraction for 3 hours, collect the extract by filtration, extract 4 times in total, introduce the extract into a concentration tank and concentrate in vacuum at 60°C (the first and second extracts are concentrated separately, the third and fourth extracts Combine and concentrate), recover the acetone solvent; obtain 60kg of crude extract, add 60kg of 80-120 mesh silica gel to mix the sample, and dry it under reduced pressure at 50°C, separate the dried silica gel on a silica gel column by column chromatography, and use petroleum ether (analytical Pure): Ethyl acetate (analytical pure) is eluted with a mixed solvent with a volume ratio of 6:1. During the elution process, different components will be eluted in seque...
Embodiment 2
[0018] Add 900kg of Artemisia annua residue into the extraction tank at one time, then add a total of 16000L of methanol (analytical pure) into the extraction tank, add in four times, each addition is 4000L, each time at 53°C and 0.06MP steam After depressing and refluxing for 2 hours, collect the extract by filtration, and extract 4 times in total. Put the extract into a concentration tank and concentrate in vacuum at 60°C (the first and second extracts are concentrated separately, and the third and fourth extracts Combine and concentrate), recover the methanol solvent; obtain 60kg of crude extract, add 60kg of 80-120 mesh silica gel to mix the sample, and dry it under reduced pressure at 50°C, separate the dried silica gel on a silica gel column by column chromatography, and use petroleum ether (analytical Pure): Ethyl acetate (analytical pure) is eluted with a mixed solvent with a volume ratio of 7:1. During the elution process, different components will be eluted in sequenc...
Embodiment 3
[0020] The same method as in Example 1 was used to extract scopoletin, except that the amount of the used extraction solvent acetone (analytical pure) was different, and the total amount of acetone added was 12000L: during column chromatography, the eluent was petroleum ether (analytical pure) : Ethyl acetate (analytical pure) mixed solvent with a volume ratio of 5:1. The obtained light yellow crude crystals of scopoletin were 1.22 kg.
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