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Method for extracting ursolic acid from red jujube

An extraction method and technology of ursolic acid, which are used in pharmaceutical formulations, non-central analgesics, preparations for skin care, etc., can solve the problems of short processing time and difficult processing, and achieve high extraction efficiency and high product purity. Effect

Inactive Publication Date: 2012-01-18
SHAANXI UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because cornus is used for large-scale food processing for a short period of time, the processing is relatively difficult, and there are few health foods related to cornus in the market.

Method used

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  • Method for extracting ursolic acid from red jujube
  • Method for extracting ursolic acid from red jujube

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1: First, wash the ground red dates, dry them at 50° C. to constant weight, and crush them through a 60-mesh sieve. Weigh the dry powder of jujube into a flask, then add 20 times the mass of jujube, and the volume fraction is 80% ethanol aqueous solution (80mL of absolute ethanol and 20mL of distilled water are miscible) as an extraction solvent.

[0031] Then, move the flask into the microwave reactor, set the microwave control temperature to 70°C, the power to 300W, the microwave action time to 90s, and stir at a fixed speed. After the reactor stops, take out the flask and cool it at room temperature for 20 minutes. Continue the microwave reaction under the same setting conditions, and the cumulative time of each microwave action reaches 90s. The extract was centrifuged at 3000r / min for 20min, the centrifuge tube was taken out, the extraction supernatant was poured into a container, and then filtered under reduced pressure to collect the filtrate.

[0032]...

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Abstract

The invention discloses a method for extracting ursolic acid from red jujubes, and is characterized in that the method comprises the following steps: cleaning and drying red jujubes, pulverizing the red jujubes, weighing red jujube dry powder, adding an ethanol aqueous solution with an amount of 20 times of the weight of the red jujubes as an extraction solvent; then, transferring the solution into a microwave reactor with a microwave control temperature being set at 60-80 DEG C, power of 200-400 W, microwave action time of 80-100 s, cooling, repeating the operations of microwave reaction and cooling for 1-10 cycles, centrifuging the extract, performing reduced-pressure filtration of the supernatant, collecting the filtrate, performing reduced-pressure distillation to obtain an ursolic acid extractum; finally, washing the extractum with distilled water and petroleum ether, filtering, dissolving the extractum with anhydrous ethanol, adding active carbon for decoloration, performing recrystallization, performing suction filtration to obtain the ursolic acid extract. The extraction method of the invention has high extraction efficiency, and the ursolic acid extract obtained by the extraction method of the invention has high product purity.

Description

technical field [0001] The invention relates to a method for extracting natural products, in particular to a method for extracting ursolic acid from red dates. Background technique [0002] Ursolic acid (Ursolic acid, UA), also known as ursolic acid, ursolic acid, is an α-amyresin alcohol type pentacyclic triterpenoids. Pure ursolic acid is a white needle-like crystal with a melting point of 285-287°C, easily soluble in dioxane and pyridine, soluble in methanol and ethanol, slightly soluble in acetone, slightly soluble in benzene, chloroform and ether. In nature, ursolic acid is mainly distributed in various plants such as Ligustrum lucidum, Hawthorn, Prunella vulgaris, Plantain and Kudingcha, and has been widely used in the fields of medicine, food, health care and cosmetics. [0003] Ursolic acid has a wide range of biological activities, especially in anti-tumor, anti-oxidation, antibacterial and anti-viral, liver protection, beauty and skin care, etc., which deserves at...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/56A61P35/00A61P31/04A61P31/08A61P31/12A61P29/00A61P1/16A23L1/29A61K8/63A61Q19/08A61Q19/00A23L33/00
Inventor 刘军海葛红光李志洲聂峰
Owner SHAANXI UNIV OF TECH
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