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Soluble alginate/carboxymethyl carrageenan composite antibacterial fiber and preparation method thereof

A technology of carboxymethyl carrageenan and carboxymethyl carrageenan, which is applied in the field of medical biopolymer material science, can solve the problems of difficult diffusion, high viscosity, difficult absorption, etc., and achieves simple process, low cost, high biological activity and antibacterial properties. performance effect

Active Publication Date: 2012-01-18
深圳禾励科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when carrageenan is not degraded, it has high viscosity, difficult diffusion, difficult absorption, and high toxicity, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] A preparation method of soluble alginate / carboxymethyl carrageenan composite antibacterial fiber, comprising the following steps:

[0023] (1) Preparation of carboxymethyl carrageenan:

[0024] Weigh 2g of sodium hydroxide and dissolve it in 8ml of distilled water, pour it into a three-neck flask, add 30ml of 70wt% ethanol solution and 10g of carrageenan at the same time, and alkalinize it at 40°C for 1 hour to obtain carrageenan lye;

[0025] Weigh 5 g of chloroacetic acid and basify it completely in NaOH solution to obtain sodium chloroacetate solution. Pour 30ml of 70wt% ethanol solution into the three-necked flask, dropwise add sodium chloroacetate solution to the reaction system, then add 4ml of 30wt% NaOH solution into the three-necked flask, and react at 60°C for 6 hours;

[0026] After the reaction was completed, the product was filtered with suction, and the filter cake was washed three times with absolute ethanol. Then dry it in a constant temperature air dr...

example 2

[0031] A preparation method of soluble alginate / carboxymethyl carrageenan composite antibacterial fiber, comprising the following steps:

[0032] Preparation of carboxymethyl carrageenan:

[0033] Weigh 4g of sodium hydroxide and dissolve it in 12ml of distilled water, pour it into a three-neck flask, add 60ml of 75 wt% ethanol solution and 15g of carrageenan at the same time, and alkalinize it at 40°C for 1.5 hours to obtain carrageenan lye;

[0034] Weigh 8g of chloroacetic acid and basify it completely in NaOH solution to obtain sodium chloroacetate solution. Pour 60ml of 75wt% ethanol solution into the three-necked flask, and at the same time add dropwise sodium chloroacetate solution to the reaction system, then add 6ml of 35wt% NaOH solution into the three-necked flask, and react at 60°C for 7 hours;

[0035] After the reaction was completed, the product was filtered with suction, and the filter cake was washed three times with absolute ethanol. Then dry it in a consta...

example 3

[0040] A preparation method of soluble alginate / carboxymethyl carrageenan composite antibacterial fiber, comprising the following steps:

[0041] Preparation of carboxymethyl carrageenan:

[0042] Weigh 6g of sodium hydroxide and dissolve it in 14ml of distilled water, pour it into a three-neck flask, add 100ml of 80wt% ethanol solution and 20g of carrageenan at the same time, and alkalinize it at 40°C for 2 hours to obtain carrageenan lye;

[0043] Weigh 12g of chloroacetic acid and basify it completely in NaOH solution to obtain sodium chloroacetate solution. Pour 100ml of 80wt% ethanol solution into the three-necked flask, and at the same time add dropwise sodium chloroacetate solution to the reaction system, then add 8ml of 40wt% NaOH solution into the three-necked flask, and react at 60°C for 8 hours;

[0044] After the reaction was completed, the product was filtered with suction, and the filter cake was washed three times with absolute ethanol. Then dry it in a consta...

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Abstract

The invention relates to soluble alginate / carboxymethyl carrageenan composite antibacterial fiber and a preparation method thereof. The soluble alginate / carboxymethyl carrageenan composite antibacterial fiber is characterized in that the soluble alginate / carboxymethyl carrageenan composite antibacterial fiber is prepared from a solution obtained from the mixing of soluble alginate, carboxymethyl carrageenan and a nano silver dispersion solution by adopting a wet spinning method, wherein the carboxymethyl carrageenan is obtained by carrying out a reaction on a carrageenan alkali liquor and sodium chloroacetate at 55-70 DEG C for 5-7 hours, cooling and purifying, and each raw material comprises the following components in percentage by weight: 19-94.5% of soluble alginate, 5-80% of carboxymethyl carrageenan and 0.5-1% of nano silver dispersion solution. The preparation method has wide raw material sources, and low cost; the technology is simple and convenient, and is good for popularization; and the prepared soluble alginate / carboxymethyl carrageenan composite antibacterial fiber has outstanding water absorption performance and mechanical performance, has good biocompatibility, and has higher bioactivity and antibacterial performances.

Description

technical field [0001] The invention relates to a soluble alginate / carboxymethyl carrageenan composite antibacterial fiber and a preparation method thereof, belonging to the scientific field of medical biopolymer materials. Background technique [0002] Alginic acid is a natural linear polysaccharide extracted from brown algae, composed of , mannuronic acid and , Guluronic acid composition. The calcium salt of alginic acid is widely used in medical dressings. When it comes into contact with the pus and blood on the wound, the sodium ions in the human body exchange with the calcium ions on the dressing. When more and more sodium ions enter the dressing, the dressing itself is slowly transferred from water-insoluble calcium alginate to water-soluble sodium alginate, and at the same time a large amount of water enters the dressing to form a layer of wet hydrogel, thus Provide the wound with a moist healing environment. Many clinical trials have proved that medical dre...

Claims

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Application Information

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IPC IPC(8): D01F8/18D01F1/10D01D5/06C08B37/00A61L15/28
Inventor 樊李红李名家王丽波彭铠
Owner 深圳禾励科技有限公司
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