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Application of hemopoietic pill in preparation of medicine for preventing or repairing cell damage caused by environmental pollutions

A technology of Shengxue pills and medicines, which can be used in drug combination, pill delivery, anti-tumor drugs, etc., and can solve problems such as biological chromosome damage

Inactive Publication Date: 2012-03-14
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results show that formaldehyde pollution can cause biological chromosome damage

Method used

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  • Application of hemopoietic pill in preparation of medicine for preventing or repairing cell damage caused by environmental pollutions
  • Application of hemopoietic pill in preparation of medicine for preventing or repairing cell damage caused by environmental pollutions
  • Application of hemopoietic pill in preparation of medicine for preventing or repairing cell damage caused by environmental pollutions

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Part 1 Pathological study of Shengxue Pills repairing bone marrow cell damage caused by lead pollution

[0017] 1 Materials and methods

[0018] 1.1 Animals

[0019] The Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army provided 150 male BalB / C mice, weighing 20±2g, aged 8-12 weeks, license number SCXK-(Army) 2007-004.

[0020] 2.2 Main materials and reagents

[0021] Rapid Giemsa stain: Nanjing Jiancheng Technology, batch number: 20101109

[0022] Standard fetal bovine serum: 100ml, Sino-US joint venture Lanzhou Minhaisheng Engineering Co., Ltd., batch number: 20100921 heparin sodium

[0023] Injection: 2ml, 12,500 units, batch number: 20100502

[0024] Trichlorfon: 250mg, Sigma, lot number: 8021X

[0025] Lead acetate: 500ml, Tianjin University Kewei Company, batch number: October 9, 2008 Hydroxyl radical detection kit: Nanjing Jiancheng Technology, batch number: 20110224

[0026] Superoxide anion d...

Embodiment 2

[0069] Part II Pathological Study of Shengxue Pills in Repairing Bone Marrow Cell Damage Induced by Cigarette Smoke

[0070] The experiment was carried out according to the method of the first part of Shengxue pill repairing the pathological research of bone marrow cell damage caused by lead pollution. The similarities will not be repeated, and the differences are as follows:

[0071] 1. Animal model preparation, grouping and administration

[0072] 150 BalB / C mice, male, weighing 20±2g, aged 8-12 weeks. Divided into five groups: normal group, 30 rats, normal food and water for 30 days; model group 1, 30 rats, cigarette smoke environment chamber smoking 1h / day, normal food, normal drinking water for 20 days, normal food, normal drinking water for 20 days ; Model group 2, 30 rats, normal food, normal drinking water for 20 days, then change to cigarette smoke environment cabin to inhale for 1h / day, 20 days; prevention group, 30 rats, Shengxue pill 2.5g / kg, normal drinking water...

Embodiment 3

[0091] Part III Pathological study of Shengxue Pills repairing xylene-induced bone marrow cell damage

[0092] The experiment was carried out according to the method of the first part of Shengxue pill repairing the pathological research of bone marrow cell damage caused by lead pollution. The similarities will not be repeated, and the differences are as follows:

[0093] 1. Animal model preparation, grouping and administration

[0094] 150 BalB / C mice, male, weighing 20±2g, aged 8-12 weeks. Divided into five groups: normal group, 30 rats, normal food and drinking water for 30 days; model group 1, 30 rats, xylene environment chamber inhalation 1h / day, normal food, normal drinking water for 20 days, normal food, normal drinking water for 20 days ; Model group 2, 30 rats, received normal food, after 20 days of normal drinking water, changed xylene environment chamber to inhale 1h / day for 20 days; prevention group, 30 rats, received Shengxue pill 2.5g / kg, normal drinking water fo...

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Abstract

The invention discloses application of a hemopoietic pill in the preparation of a medicine for preventing or repairing medullary cell damage caused by environmental pollutions, wherein the environmental pollutions are lead pollution, cigarette pollution, benzene pollution, dimethylbenzene pollution and formaldehyde pollution, and the preventing or the repairing of the medullary cell damage refers to the restraint of the proliferation of a precancerous cell. In the invention, the functions that the hemopoietic pill resists to the teratogenesis caused by the environmental pollutions are inspected on aspects of the change of the micronucleus rate of blood lymphocytes and marrow, the elimination capability of free radicals, the restraint of the proliferation of the precancerous cell, and the like, and the wider foreground is opened up for the clinical application of the hemopoietic pill.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to new uses of traditional Chinese medicines, in particular to the application of Shengxue Pills in the preparation of medicines for preventing or repairing cell damage caused by environmental pollution. Background technique [0002] Darentang Shengxue Pills originated from decades of clinical prescriptions by Professor Xie Haizhou, a famous veteran Chinese medicine doctor at Guang'anmen Hospital, Academy of Traditional Chinese Medicine. It is good at invigorating kidney yang and kidney essence, and blood is prosperous when essence is sufficient. According to modern research, Shengxue Pill has many functions such as protecting liver and gallbladder, anti-tumor, anti-oxidation, sedation, and lowering blood sugar. It has definite curative effect in treating pancytopenia and aplastic anemia after radiotherapy and chemotherapy. There are velvet antler, P...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/20A61P35/02A61P35/00A61P39/06A61K35/32A61K35/50
Inventor 严苏纯王光普张晓乐
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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