Garlic enteric-coated tablets and production method thereof

Abstract

The invention relates to the technical field of garlic enteric-coated tablets, in particular to garlic enteric-coated tablets and a production method thereof. The garlic enteric-coated tablets are prepared from the following raw materials: freeze-dried garlic powder, microcrystalline cellulose, pre-gelatinized starch, sodium carboxymethyl starch, povidone K30, silicon dioxide serving as a pharmaceutic adjuvant, magnesium stearate and a medical film coating premixed adjuvant. The obtained garlic enteric-coated tablet products are qualified and unsplit in appearances and qualified in disintegration time, so the flake appearances of the obtained garlic enteric-coated tablet products are kept complete under the action of a gastric acid solution, film coatings of the products are dissolved under the action of an enteric solution, the products is disintegrated and released, and active ingredients are digested and absorbed by an intestinal tract; however, products produced by the conventional known process are long in disintegration time in the intestinal tract, so that the active ingredients of the products cannot be timely released and are discharged from the body, and the actual effects of the products are reduced.

Description

technical field [0001] The invention relates to the technical field of garlic enteric-coated tablets, and relates to a garlic enteric-coated tablet and a production method thereof. Background technique [0002] The garlic enteric-coated tablet in the prior art is an enteric-coated film-coated tablet, which uses freeze-dried garlic powder and a small amount of excipient whole powder to directly compress the tablet, and then wraps it with an enteric-coated film coating. This product is recorded in the national drug standard varieties. [0003] The freeze-dried garlic powder of the prior art uses fresh garlic as the main raw material, and is processed by freezing and crushing, low-temperature vacuum drying, etc., retains the biological activity of fresh garlic, and contains alliin, alliinase and selenium-containing organic compounds Chemical components such as allicin can be converted into allicin in the human body to achieve the purpose of health care and treatment. Bec...

AI Technical Summary

Problems solved by technology

[0005] The garlic enteric-coated tablet products in the prior art have the following defects: the defect is first, the appearance is unqualified, the lobes are less than 5% when the product is produced, and the expiry date In two years (two years), the lobes reached more than 50%, and the quality standard stipulated that the appearance should be complete without any lobes; the traditional solution was to pick out the lobes manually after the tablet pressing, and then coat them, resulting in a decrease in the yield, and There is no guarantee that the product will not splinter within the expiry date

The defects of the lobes first lead to the failure of the product to meet the quality standards. At the same time, the lobes cause the active ingredients to be released in the stomach, losing the effect of its enteric coating, and the stomach will be stimulated by the active ingredients of garlic, and the mouth will smell garlic. Phenomena such as taste

The second defect is that the disintegration time limit is unqualified. The measured value of the intestinal juice disintegration time of the product is 58 minutes to 65 minutes. The active ingredients cannot be released in time, that is, they are excreted from the body, which reduces the effectiveness of the product

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