Application of protein acetylation enzyme SIRT1 (Silent Mating type Information Regulation 2Homolog1) in promoting proliferation and delaying senility of mesenchymal stem cells

A technology of sirtuin and mesenchymal stem cells, which is applied in the application field of protein sirtuin SIRT1 in promoting the proliferation of mesenchymal stem cells and delaying aging, and can solve the problems of MSC proliferation stagnation and cell aging
CN102382801AActive Publication Date: 2012-03-21FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
Publication Date
2012-03-21

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Abstract

The invention discloses an application of protein acetylation enzyme SIRT1 (Silent Mating type Information Regulation 2Homolog1), namely promoting proliferation and delaying senility of mesenchymal stem cells. The experimental result shows that the SIRT1 is needed by the in vitro proliferation of the mescenchymal stem cells, and the condition is verified by MSC (mesenchymal stem cells from marrow) and MSC from fat, and the proliferation and the senility of the MSC can be regulated by regulating the expression level of SIRT1 in the MSC. The invention has very important significances on the determination of the regulation mechanism of the proliferation and the senility of the MSC, the prolonging of the service life of the MSC, and the histocyte substitution and repairing treatment based on the MSC, and is broad in application prospect.
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Description

technical field

[0001] The invention belongs to the new application of enzymes, in particular to the application of protein deacetylase SIRT1 in regulating the proliferation and aging of mesenchymal stem cells. Background technique

[0002] SIRT1 (silent mating type information regulation 2homolog 1), a member of the Sirtuin family (SIRT1-7), is a highly conserved multifunctional NAD-dependent protein deacetylase from bacteria to humans. It prolongs the lifespan of lower organisms such as yeast, fruit flies and nematodes. In higher animals such as mice and humans, it participates in the regulation of various life activities such as malignant tumor formation and chemotherapy resistance, stress response, cell metabolism and aging, so as to treat malignant tumors, diabetes, vascular aging and Parkinson's diseases potential target has attracted widespread attention.

[0003] Bone marrow or adipose-derived mesenchymal stem cells (MSCs) have the following advantages: 1) It is co...

Claims

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