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Purpose of bacillus subtilis glycopeptide 168

A Bacillus subtilis and glycopeptide technology is applied in the field of use of Bacillus subtilis glycopeptide 168 in livestock feeding, which can solve problems such as inability to effectively solve diseases, and achieves promoting livestock growth, treating livestock diarrhea, and improving feed utilization. Effect

Active Publication Date: 2013-12-25
李叶青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long-term and irregular addition of antibiotics and the emergence of drug resistance problems, the antibiotics in the prior art cannot effectively solve the diseases that occur in the process of raising livestock, and often relapse after medication

Method used

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  • Purpose of bacillus subtilis glycopeptide 168

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A chicken farm, chicken farms have reduced food intake during feed conversion, the chickens are in a trance, not active enough when eating and moving, the feces are softer than normal, and there is a tendency to loose stools. At this time, if antibiotics are used for treatment, it will easily lead to the appearance of intestinal diseases, and coccidiosis will occur later in the medication. In addition, due to the emergence of gastrointestinal diseases, the intestinal function is abnormal, and they cannot be completely digested after eating, resulting in some chickens having diarrhea.

[0030] As a livestock health care and growth-promoting additive, subtilisin 168 was added to chicken diets. The weight ratio of deodorrholycerin 168 in the food feed is 5th to sixth of the tens of millions.

[0031] Compared with the antibiotic-supplemented group, chickens fed with subtilisin 168 had significantly increased food intake, and were more active when walking and eating. Duri...

Embodiment 2

[0033] In pig farm B, the food intake of the sows has not returned to the normal level in about a week after delivery, and the suckling piglets have diarrhea 3 days after delivery. The use of antibiotics as postpartum health care and nursing medicines for sows has no obvious effect.

[0034] Subtilisin 168 was used in the diet based on the use of health products for the prevention and treatment of sows. The subtilis glucopeptin 168 is directly added to the ration of the sow, and the weight ratio of the subtilis glucopeptin 168 in the ration is 8 to 10 parts per million by weight. Continuous feeding is used for about 10 days.

[0035] The food intake of the sows returned to normal levels about 3 days after feeding the drug, and various physiological indicators also returned to normal ranges, which reduced the chances of the sows being infected with other diseases. The diarrhea symptoms of the piglets gradually improved and disappeared, and the weight gradually increased.

[...

Embodiment 3

[0038] Mastitis is a common and high incidence of dairy cows. The usual treatment for cows with mastitis is conventional antibiotics. In addition to the unsatisfactory treatment effect due to the emergence of antibiotic resistance, the more important thing is that milk needs to be discarded during and after treatment, and the resulting economic losses are obvious.

[0039] Dairy farmer C applied subtilisin 168 to the affected areas of several cows suffering from mastitis, and recovered within a week. It shows that the subtilisin 168 can effectively kill its pathogen Staphylococcus aureus.

[0040] The third part is to use subtilis glucopeptin 168 in the process of raising livestock, and subtilis glucopeptin 168 is used as a surface disinfectant to disinfect the growth environment of livestock:

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Abstract

The invention discloses a purpose of bacillus subtilis glycopeptide 168. The bacillus subtilis glycopeptide 168 is used in the livestock raising process, added antibiotics for livestock raising in the prior art are replaced or partially replaced, and the harm to the livestock body caused by the antibiotics is reduced. The bacillus subtilis glycopeptide 168 can realize the health care effects of enhancing the immunity of the livestock and eliminating various diseases generated in the livestock raising process, the livestock growth is promoted, the feed utilization rate is improved, in addition, no residue can be left in the livestock body, and no side effect can be caused on human bodies. The bacillus subtilis glycopeptide 168 solves the problem of side effect on the human bodies caused by residue of the antibiotics used in the livestock raising process in the livestock body, so the food safety is perfectly ensured.

Description

technical field [0001] The present invention relates to an additive for livestock feeding, in particular to the application of subtilisin 168 in livestock feeding. Background technique [0002] U.S. Patent Document (Patent No. US 7,358,076 B2) discloses an antimicrobial peptide produced by Bacillus subtilis named Sublancin 168 (in this patent application, it is collectively referred to as "subtilisin 168" in Chinese), which The amino acid sequence is as follows [Xaa is a dehydrogenated Thr(Dhb)]: [0003] Gly Leu Gly Lys Ala Gln Cys Ala Ala Leu Trp Leu Gln Cys Ala Xaa [0004] 1 5 10 15 [0005] Gly Gly Xaa Ile Gly Cys Gly Gly Gly Ala Val Ala Cys Gln Asn Tyr [0006] 20 25 30 [0007] Arg Gln Phe Cys Arg [0008] 35 [0009] There are thioether and disulfide bonds in subtilisin 168, and its structural formula is as follows figure 1 shown. [0010] Subtilisin 168 can kill bacteria or inhibit bacterial growth, and has a good inhibitory effect on G...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A23K1/17A01N43/90A01P1/00A61P31/04A23K20/195
CPCY02A40/70
Inventor 李叶青
Owner 李叶青
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