Unlock instant, AI-driven research and patent intelligence for your innovation.

Fluorine-18 fluorodeoxyglucose (18F-FDG) kit and application thereof in synthesis of positron emission tomography (PET) developer FDG

A 18F-FDG and kit technology, which is applied in the 18F-FDG kit and the application field of synthetic PET imaging agent FDG, can solve the problems of high anhydrous requirements, large product loss, and long time consumption, so as to reduce the preparation time , Improve stability and improve yield

Active Publication Date: 2013-01-23
JIANGSU HUAYI TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are:
[0005]1. Different raw materials need to be purchased from different suppliers, and the raw materials are subpackaged and prepared on site, which takes a long time and the supply of raw materials is not enough Stablize;
[0006]2. It is difficult to achieve an anhydrous environment for on-site subpackaging. For the acetonitrile solution of mannose triflate, the requirement for anhydrous in this step is extremely high. Once anhydrous There is no guarantee that the reaction efficiency will be reduced;
[0007]3. Unstable yield and unstable product quality
[0008]In addition, the current synthesizer mostly adopts the method of connecting cation exchange column, anion exchange column, alumina column and macroporous resin column for purification, resulting in excessive dead volume Many, large product loss

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fluorine-18 fluorodeoxyglucose (18F-FDG) kit and application thereof in synthesis of positron emission tomography (PET) developer FDG
  • Fluorine-18 fluorodeoxyglucose (18F-FDG) kit and application thereof in synthesis of positron emission tomography (PET) developer FDG

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The kit contains: 2.2g octadecadecane; 30mg trifluoromannose; 25mg cryptand 222; 10ml acetonitrile; 30ml absolute ethanol; 1ml 1mol / L sodium hydroxide aqueous solution, in the purification column from top to bottom Packed with 2.5g of sulfonic acid H with PVP-DVB as the carrier + Cation exchange resin, 5g HCO with PVP-DVB as carrier 3 - Type anion exchange resin, 2.5g alumina and 1.2g polystyrene-divinylbenzene type macroporous resin; the vacuum degree is 0.09~0.1MPa vacuum bottle.

[0033] The GE Tracerlab Fx-Fn model FDG synthesizer used the above kits and manually prepared reagents to synthesize FDG, and the results are shown in Table 1.

[0034] synthesis preparation time synthesis time Synthetic FDG Yield FDG product purity Reagent test kit 15min 100 75.0% >99% Handmade 50min 110 64.1% >99%

Embodiment 2

[0036] The kit contains: 1.8g octadecadecane; 20mg trifluoromannose; 0.6ml 0.15M tetrabutylammonium hydroxide aqueous solution; 5ml acetonitrile; 10ml absolute ethanol; 1ml 1mol / L hydrochloric acid solution. 1.5g of sulfonic acid H with PVP-DVB as carrier + Cation exchange resin, 3.0g HCO with PVP-DVB as carrier 3 - Type anion exchange resin, 1.5g alumina and 0.7g polystyrene-divinylbenzene type macroporous resin; the vacuum degree is 0.09~0.1MPa vacuum bottle.

[0037] The GE Tracerlab Fx-FDG model FDG synthesizer used the kit of the present invention and manually prepared reagents to synthesize FDG, and the results are shown in Table 2.

[0038] synthesis preparation time synthesis time Synthetic FDG Yield FDG product purity Reagent test kit 13min 100 74.2% >99% Handmade 55min 106 62.8% >99%

Embodiment 3

[0040]The kit contains: 1.8g octadecadecane; 20mg trifluoromannose; 20mg cryptand 222; 5ml acetonitrile; 10ml absolute ethanol; 1ml 1mol / L hydrochloric acid solution. 2.0g of sulfonic acid H with PVP-DVB as the carrier + Cation exchange resin, 4.0g HCO with PVP-DVB as carrier 3 - Type anion exchange resin, 2.0g alumina and 1.0g polystyrene-divinylbenzene type macroporous resin; the vacuum degree is 0.09~0.1MPa vacuum bottle.

[0041] The BIOSCAN FDG PLUS Module model FDG synthesizer used the kit of the present invention and manually prepared reagents to synthesize FDG, and the results are shown in Table 3.

[0042] synthesis preparation time synthesis time Synthetic FDG Yield FDG product purity Reagent test kit 16min 100 75.8% >99% Handmade 52min 107 66.3% >99%

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a fluorine-18 fluorodeoxyglucose (18F-FDG) kit, which comprises oxygen-18 water, mannose triflate, phase transfer catalyst, acetonitrile, ethanol, hydrolysis reagent and a spin column. Through preparation in advance, by adopting fixed proportions and by packaging in a clean anhydrous environment, high-yield, high-stability and high-quality FDG can be obtained.

Description

technical field [0001] The invention relates to the technical field of nuclear medicine, in particular to a 18 F-FDG kit and its application in the synthesis of PET imaging agent FDG. Background technique [0002] Positron emission tomography (PET, hereinafter referred to as "PET") is an imaging device that reflects the gene, molecule, metabolism and functional status of the disease. It uses positron nuclide-labeled glucose and other human metabolites as imaging agents, and reflects its metabolic changes through the uptake of imaging agents by lesions, thereby providing clinical biological metabolism information of diseases. It is a new milestone in the development of life science and medical imaging technology. [0003] PET uses the nuclide of the positron emitter to label some physiologically necessary compounds or metabolic substrates such as glucose, fatty acids, amino acids, receptor ligands and water, etc., after being introduced into the body, the in vivo chemical i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H5/02C07H1/00A61K51/00A61K101/02
Inventor 徐志红桂媛
Owner JIANGSU HUAYI TECH