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Starch hemostatic microsphere and preparation method thereof

A technology of starch and microspheres, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor hemostatic effect of large blood vessels, blood-borne disease infection, insufficient water absorption, etc., and achieve improved hemostatic effect and biocompatibility Good performance and low production cost

Active Publication Date: 2012-04-11
天津红日爱乐意药用辅料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The disadvantages of this type of material are high cost, possible infection of human or animal blood-borne diseases, inconvenient use, slow hemostasis, and poor hemostatic effect on large blood vessels
However, there are still deficiencies in the hemostatic effect of this effective hemostatic material, its water absorption is not strong enough, and the water absorption multiple is low, thus affecting the hemostatic effect

Method used

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  • Starch hemostatic microsphere and preparation method thereof
  • Starch hemostatic microsphere and preparation method thereof
  • Starch hemostatic microsphere and preparation method thereof

Examples

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Embodiment 1

[0048] A preparation method of starch hemostatic microspheres, the steps are as follows:

[0049] (1) Preparation of starch alkaline solution: weigh 1g of pea starch, 2g of potato starch, 2g of cornstarch, 30-100ml of distilled water, dissolve the starch in distilled water, adjust the pH to 8.5-10.5 with 1mol / L NaOH, stir for 2 hours, and stir The speed is 400-600r / min, and the activated starch alkaline solution is obtained;

[0050] (2) Preparation of vegetable oil-starch mixed solution: after mixing 1-3g of surfactant span600 and 200-1000ml of vegetable oil, stir in a water bath at 60-80°C for 0.5-2h, and then add it to the starch lye in step (1), Stir and mix for 2 to 4 hours to obtain a vegetable oil-starch mixed solution;

[0051] (3) Cross-linking treatment: dropwise add 1-5 ml of cross-linking agent epichlorohydrin to the vegetable oil-starch mixed solution obtained in step (2), and the time for dropping is 1-2 hours to form a reaction system, react for 4-6 hours, The...

Embodiment 2

[0054] A preparation method of starch hemostatic microspheres, the steps are as follows:

[0055] (1) Preparation of starch alkaline solution: weigh 1g of mung bean starch, 2.5g of tapioca starch, 3g of cornstarch, 30-100ml of distilled water, dissolve the starch in distilled water, adjust the pH to 8.5-10.5 with 1mol / L NaOH, stir for 2h, The stirring speed is 400-600r / min, and the activated starch alkaline solution is obtained;

[0056] (2) Preparation of vegetable oil-starch mixed solution: after mixing 1-3g of surfactant span600 and 200-1000ml of vegetable oil, stir in a water bath at 60-80°C for 0.5-2h, and then add it to the starch lye in step (1), Stir and mix for 2 to 4 hours to obtain a vegetable oil-starch mixed solution;

[0057] (3) Cross-linking treatment: dropwise add 1-5 ml of cross-linking agent epichlorohydrin to the vegetable oil-starch mixed solution obtained in step (2), and the time for dropping is 1-2 hours to form a reaction system, react for 4-6 hours, ...

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Abstract

The invention relates to a starch hemostatic microsphere and a preparation method thereof. The starch hemostatic microsphere is prepared from legume starch, potato starch and cereal starch which serve as raw materials by virtue of an inverse suspension polymerization method, and has a molecular weight of between 50000 and 5000000 and the grain diameter of between 0.1 and 1000mu m. The preparationmethod of the starch hemostatic microsphere comprises the following steps: mixing the three types of raw starches, and alkalizing; dispersing with a surfactant and vegetable oil under a condition that the pH is between 8.5 and 10.5; performing crosslinking with a crosslinking agent; cleaning, and performing spray drying; and packaging, and sterilizing with cobalt 60. The starch hemostatic microsphere prepared by using the method has good biocompatibility, and is used for a hemostatic process of a surgical operation; the water absorption rate is multiple times that of a conventional hemostaticmaterial, the water absorption speed is remarkably increased, and the hemostatic effect is reinforced. The starch hemostatic microsphere has easily available raw materials, simple process, low production cost and wide application prospect.

Description

technical field [0001] The invention belongs to the field of hemostatic agents, and relates to a starch hemostatic agent, in particular to a starch hemostatic microsphere and a preparation method thereof. Background technique [0002] Surgical hemostasis is one of the cores of surgical techniques, and a good hemostasis technique is the key to a successful operation. With the improvement of the effectiveness and safety requirements of the medical circles in various countries, it is imperative to find excellent biological materials in nature and develop hemostatic materials with better hemostatic effect, no toxic side effects, no irritation, and easy to process. Row. Absorbable hemostatic materials currently used in surgical and traumatic wounds mainly include: [0003] 1. Fibrin glue [0004] Fibrin glue, also known as fibrin adhesive, is a biological product extracted from human plasma, mainly composed of thrombin and fibrinogen, and has been widely used clinically for ma...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42
Inventor 郭雅楠李军
Owner 天津红日爱乐意药用辅料有限公司
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