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Medicinal composition containing tetrahydropalmatine and imperatorin

A technology of tetrahydropalmatine and imperatorin, which is applied in the field of medicine and can solve the problems of large dosage and single effect

Inactive Publication Date: 2012-05-02
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Animal experiments have been used to find that the combination of corydalidin and imperatorin with a weight ratio of (1-8): (1-5) can significantly improve the analgesic effect of corydalidin and produce a synergistic effect; Together for pain and discomfort, including headache, migraine, stomach pain, neuralgia, low back pain, menstrual pain, etc. have a good therapeutic effect, overcome the single use of drugs with large dosage, the single effect of the shortcomings; this effect and Tetrahydropalmatine and The effect of imperatorin on different targets plays a role in the drug's overall therapeutic synergistic effect

Method used

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  • Medicinal composition containing tetrahydropalmatine and imperatorin
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  • Medicinal composition containing tetrahydropalmatine and imperatorin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] (1) Prescription

[0065]

[0066] (2) Preparation method

[0067] Weigh the prescribed amount of tetrahydropalmatine, imperatorin, cross-linked polyvinylpyrrolidone, and microcrystalline cellulose, mix evenly, add 2% hypromellose aqueous solution as a binder soft material, and granulate with a 20-mesh sieve , dried at 50°C for 3 hours, sieved with a 20-mesh sieve, added the prescribed amount of talc powder and magnesium stearate, mixed evenly, and pressed into tablets. Each tablet contains a total of 100mg of the main drug.

[0068] (3) Determination of disintegration time and dispersion uniformity

[0069] Take 6 pieces of samples, place them in the glass tube of the hanging basket of the disintegration apparatus respectively, immerse the hanging basket in a 1000ml beaker, and adjust the position of the hanging basket so that the screen mesh is 25mm away from the bottom of the beaker when it descends, and the temperature of the beaker is ( For water at 37±1)°C, ...

Embodiment 2

[0072] (1) Prescription

[0073]

[0074]

[0075] (2) Preparation method

[0076] 1) Weigh the prescribed amount of tetrahydropalmatine and imperatorin through a 100-mesh sieve, sodium carboxymethyl starch, aspartame, and microcrystalline cellulose through a 80-mesh sieve, fully mix the above raw and auxiliary materials, and set aside .

[0077] 2) Preparation of the adhesive: take the whole amount of polyvinylpyrrolidone K30 to make a 5% aqueous solution, stir until completely dissolved, and set aside.

[0078] 3) The powder in 1) is made of soft material with the binder in 2), granulated through a 20-mesh sieve, dried at 60°C, and the moisture content is controlled to be about 2%. Add the prescribed amount of talcum powder and magnesium stearate, mix well, and press into tablets. Each tablet contains a total of 100mg of the main drug.

[0079] (3) Determination of disintegration time and dispersion uniformity

[0080] Take 6 pieces of samples, and measure the dis...

Embodiment 3

[0083] (1) Prescription

[0084]

[0085] (2) Preparation method

[0086]1) Separately pass the tetrahydropalmatine and imperatorin through a 100-mesh sieve, pulverize the microcrystalline cellulose, sodium carboxymethyl starch, and aspartame, pass through a 80-mesh sieve, fully mix the above-mentioned raw and auxiliary materials, and set aside.

[0087] 2) Preparation of adhesive: take the whole amount of polyvinylpyrrolidone K30 to make a 5% aqueous solution, add surfactant sodium lauryl sulfate, and set aside.

[0088] 3) The powder in 1) is made of soft material with the binder in 2), granulated through a 20-mesh sieve, dried at 60°C, and the moisture content is controlled to be about 2%. Sieve through a 20-mesh sieve for granulation, add magnesium stearate and micropowder silica gel, mix evenly, and press into tablets to obtain the product. Each tablet contains a total of 150mg of the main drug.

[0089] (3) Determination of disintegration time and dispersion unifor...

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Abstract

The invention discloses a medicinal composition containing tetrahydropalmatine and imperatorin and application. The medicinal composition is prepared into various pharmaceutically acceptable solid oral formulations, such as granules, powder, tablets, pills and capsules, from the tetrahydropalmatine and the imperatorin in a weight ratio of (1-8):(1-5). Pharmacological tests show that the composition has the effects of suppressing pain and discomforts, including headache, migraine, stomachache, neuralgia, lumbago and menstrual pain; and the composition can be used for treating the pains.

Description

technical field [0001] The invention relates to a pharmaceutical composition of tetrahydropalmatine and imperatorin, which is used for pain, mainly various mild to moderate pain and discomfort, such as headache, migraine, stomach pain, neuralgia, low back pain, menstrual pain, etc. Treatment belongs to the technical field of medicine. Background technique [0002] Pain is a complex physiological and psychological activity and one of the most common clinical symptoms. It includes the pain sensation caused by noxious stimuli acting on the body and the body's pain response to noxious stimuli. According to the report of the American Pain Society, chronic pain affects 35.5% of the total population in the United States, or 105 million people. According to statistics, in 2009, the total value of the global pain treatment market exceeded US$50 billion, of which the total sales of analgesic drugs in the seven markets of the United States, Japan, France, Germany, the United Kingdom,...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/37A61P29/00A61P25/06A61P25/04
Inventor 曹蔚王四旺谢艳华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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