Preparation method and pharmacological effect of mangiferin hexa-butyl-esterified derivative

A technology of pharmacological effects and compounds, which is applied in the field of preparation of mangiferin hexabutyl ester derivatives and its pharmacological effects, and can solve problems such as poor absorption effect, poor gastrointestinal permeability of mangiferin, and poor permeability of mangiferin
CN102432603BInactive Publication Date: 2014-07-02GUANGXI UNIV OF CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGXI UNIV OF CHINESE MEDICINE
Publication Date
2014-07-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for chemically synthesizing a mangiferin hexa-butyl-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
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Description

technical field

[0001] The invention relates to a method for preparing a new organic compound by using mangiferin as a starting material, and the pharmacological effects of the compound in anti-inflammatory and hypoglycemic aspects. technical background

[0002] Many Chinese medicinal materials such as the fruit, leaves and bark of Mangifera indica L., the rhizome and aerial part of Liliaceae Anemarrhena asphodeloides Bge., Belamcanda chinensis (L.) DC.) flowers and leaves contain mangiferin (Mangiferin). Mangiferin is a glucose C-glycoside with a Xanthone structure (molecular formula C 19 H 18 O 11 , molecular weight 422.34).

[0003]

[0004] Mangiferin has a large planar structure and poor solubility (average solubility in pure water and buffer solution with pH 1.3 to 7.4 <1 mg·mL -1 ), and the converted human oral effective dose is 630 mg, and the liquid volume in the gastrointestinal tract required to dissolve a single dose of mangiferin is >250 mL. Accord...

Claims

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