Eye drop having Cecropins for pet and preparation method thereof

A technology of eye drops and cecropin, which is applied in the directions of medical preparations, drug combinations, and drug delivery containing active ingredients, can solve the problems of insignificant effects, threats to human health, and blindness, so as to overcome the problems of easy loss, Conducive to scale-up production, easy-to-obtain results

Inactive Publication Date: 2012-05-09
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, human eye drops are generally used for pet eye diseases, which are blind and the effect is not obvious. In the long run, it is easy to produce drug-resistant strains, which seriously threatens human health.

Method used

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  • Eye drop having Cecropins for pet and preparation method thereof
  • Eye drop having Cecropins for pet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The prescription of eye drops is:

[0031] Component Dosage

[0032] Cecropin Antimicrobial Peptide 6.4g

[0033] Water soluble chitosan 8.1g

[0034] Borneol 0.03g

[0035] Sodium chloride 8.0g

[0036] Methylparaben 0.23g

[0037] Ethylparaben 0.11g

[0038] Sodium bisulfite 1.0g

[0039] Ethanol 2mL

[0040] 18% sodium hydroxide solution appropriate amount

[0041] 12% hydrochloric acid solution appropriate amount

[0042] Water for injection to 1000mL

[0043] The preparation method of this eye drop:

[0044] (1) Under sterile conditions, weigh 6.4g cecropin antibacterial peptide and add 100mL water for injection to dissolve;

[0045] (2) Take 8.1g of water-soluble chitosan, add about 300mL of water for injection, and drop an appropriate amount of 12% hydrochloric acid solution to make it naturally peptized and completely dissolved;

[0046] (3) Take 0.03g of borneol and add about 2mL of ethanol to fully dissolve it;

[0047] (4) Take 0.23g of methylpar...

Embodiment 2

[0052] The prescription of eye drops is:

[0053] Component Dosage

[0054] Cecropin 9.4g

[0055] Water soluble chitosan 6.5g

[0056] Borneol 0.098g

[0057] Sodium chloride 4.5g

[0058] Potassium chloride 3.7g

[0059] Boric acid 1.9g

[0060] Borax 1.9g

[0061]Methylparaben 0.15g

[0062] Ethanol 2mL

[0063] 12% sodium hydroxide solution appropriate amount

[0064] 15% hydrochloric acid solution appropriate amount

[0065] Water for injection to 1000mL

[0066] The preparation method of this eye drop:

[0067] (1) Under sterile conditions, weigh 9.4g cecropin antimicrobial peptide and add 100mL water for injection to dissolve;

[0068] (2) Get 6.5g of water-soluble chitosan and add about 300mL of water for injection, and add an appropriate amount of 15% hydrochloric acid solution dropwise to make it naturally peptized and completely dissolved;

[0069] (3) Take 0.098g of borneol and add about 2mL of ethanol to fully dissolve it;

[0070] (4) Take 0.15g of ...

Embodiment 3

[0076] The prescription of eye drops is:

[0077] Component Dosage

[0078] Cecropin 5.1g

[0079] Water soluble chitosan 9.2g

[0080] Borneol 0.025g

[0081] Boric acid 21.0g

[0082] Phenylmercuric nitrate 0.02g

[0083] Ethanol 1mL

[0084] 14% sodium hydroxide solution appropriate amount

[0085] 16% dilute hydrochloric acid appropriate amount

[0086] Water for injection to 1000mL

[0087] The preparation method of this eye drop:

[0088] (1) Under sterile conditions, weigh 5.1g of cecropin antimicrobial peptide and add 100mL of water for injection to dissolve;

[0089] (2) Get 9.2g of water-soluble chitosan and add about 300mL of water for injection, add dropwise an appropriate amount of 16% hydrochloric acid solution to make it naturally peptized and completely dissolved;

[0090] (3) Take 0.025g of borneol and add about 1mL of ethanol to fully dissolve it;

[0091] (4) Get phenylmercuric nitrate 0.02g and boric acid 21.0g, add 300mL water for injection, hea...

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PUM

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Abstract

The invention relates to a novel eye drop used for pet. The main ingredients of the eye drop comprise a Cecropins antibacterial peptide, a water-soluble chitosan and a borneol. Apart from the broad-spectrum antibacterial activity, the eye drop also has the resistance effect for virus, parasite, fungus and cancer cell which can enhance the immunity and facilitate the wound healing with no resistance to drugs and no residues after long-term usage. Moreover, the water-soluble chitosan is very excellent in viscosity, mould integration property, antibacterial activity and absorbability, which can overcome the deficiencies of conventional eye drops such easy lose and frequent dose.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to eye drops for pets containing cecropin and a preparation method thereof, eye drops for curing bacterial diseases caused by common pathogenic bacteria in the eyes of pets and a preparation method thereof. Background technique [0002] With the improvement of human living standards, pets have become a member of the family. While pets bring fun to humans, they also seriously threaten human health. The living habits of pets are easy to be exposed to a large number of pathogenic bacteria, and their unique lifestyle can easily bring pathogenic bacteria into the eyes and cause infection. Human beings are in close contact with it, and it is easy to cause contact infection. At present, human eye drops are generally used for pet eye diseases, which are blind and have no obvious effect. In the long run, drug-resistant strains are easy to produce, which seriously threatens human health. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K47/36A61K9/08A61P31/04A61P27/02A61K31/045A61K31/722
Inventor 闫亮亮昌莉丽程志瑛刘莹
Owner TIANJIN RINGPU BIO TECH
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