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Preparation method of biodegradable polymer microcapsules

A polymer membrane and biological technology, applied in the molding and processing of microcapsule materials, the application of new pharmaceutical preparation materials, and the field of polymer microspheres, can solve problems such as poor spherical shape, complicated preparation process, and uneven pore size distribution, and achieve The process is gentle and avoids damage to the effect

Active Publication Date: 2012-06-13
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the experiment, biodegradable materials were selected as the shell material, but the prepared spherical shape was not good, and the pore size distribution was not uniform
Kim et al. (Kim, H.K., H.J.Chung, and T.G.Park, Biodegradable polymeric microspheres with "open / closed" pores for sustained release of human growth hormone. Journal of Controlled Release, 2006.112 (2): p.167-174) also utilize Phase separation pore-making technology uses single emulsion as a template and uses surfactant Pluronic F127 as a porogen to prepare PLGA porous microspheres with different pore sizes. After loading recombinant human growth hormone, it is solvent-sealed. The disadvantages are The preparation process is complicated, and the drug embedding rate is low

Method used

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  • Preparation method of biodegradable polymer microcapsules
  • Preparation method of biodegradable polymer microcapsules
  • Preparation method of biodegradable polymer microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Take by weighing 200mg PELA and place in test tube, add 2ml ethyl acetate and dissolve it, make oil phase; Prepare 1.0% NaCl (w / v) aqueous solution, as inner aqueous phase; Prepare 2.5% PVA (w / v) aqueous solution and Place in a separatory funnel, add excess ethyl acetate, shake well to make a saturated solution, let stand, remove the clear liquid after layering, add NaCl, and make the NaCl concentration in the saturated solution 0.5% (w / v ) as the external aqueous phase. Take 800 μl of the inner water phase and add it to the oil phase, homogeneously emulsify at 14,000 rpm for 25 seconds to form a primary emulsion; pour the primary emulsion into 15 ml of the outer aqueous phase, and homogeneously emulsify at 4,000 rpm for 60 seconds to form a double emulsion.

[0094] Put the complex emulsion into a reaction bottle, mix it vertically for 10 minutes, remove it, pour it into 10ml of deionized water, and stir it magnetically at 200 rpm for 3 minutes to pre-cure; then pour t...

Embodiment 2

[0099] Weigh 200mg of PELA into a test tube, add 2ml of ethyl acetate to dissolve it, and make an oil phase; prepare 1.5% NaCl (w / v) aqueous solution as the inner water phase. Prepare a 1.0% PVA (w / v) aqueous solution and place it in a separatory funnel, add excess ethyl acetate, shake well to make a saturated solution, let it stand, remove the clear liquid after layering, add NaCl, and make the saturated solution The concentration of NaCl in the medium is 0.5% (w / v), which is used as the external aqueous phase. Take 600 μl of the inner water phase and add it to the oil phase, homogeneously emulsify at 14,000 rpm for 25 seconds to form a primary emulsion; pour the primary emulsion into 15 ml of the outer aqueous phase, and homogeneously emulsify at 4,000 rpm for 60 seconds to form a double emulsion.

[0100] Put the complex emulsion into a reaction bottle, mix it vertically for 20 minutes, take it out, pour it into 10ml of deionized water, stir it magnetically at 200 rpm for 3...

Embodiment 3

[0104] Weigh 200mg of PELA into a test tube, add 2ml of ethyl acetate to dissolve it, and make an oil phase; prepare 2.5% NaCl (w / v) aqueous solution as the inner water phase. Prepare a 1.0% PVA (w / v) aqueous solution and place it in a separatory funnel, add excess ethyl acetate, shake well to make a saturated solution, let it stand, remove the clear liquid after layering, add NaCl, and make the saturated solution The concentration of NaCl in the medium was 1.0% (w / v), which was used as the external aqueous phase. Take 600 μl of the inner water phase and add it to the oil phase, homogeneously emulsify at 14,000 rpm for 25 seconds to form a primary emulsion; pour the primary emulsion into 15 ml of the outer aqueous phase, and homogeneously emulsify at 4,000 rpm for 60 seconds to form a double emulsion.

[0105] Put the complex emulsion into a reaction bottle, mix it vertically for 2 minutes, remove it, pour it into 10ml of deionized water, stir it magnetically at 200 rpm for 3 ...

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Abstract

The invention relates to a preparation method of biodegradable polymer microcapsules. The method mainly comprises the following steps: preparing microspheres with openings, filling a capsule core material and sealing the openings of the microspheres. The biodegradable material microcapsules can be used to encapsulate micromolecular and bio-macromolecular substances and can also be used to load nanoscale and microscale particles. Compared with the traditional multiple emulsion embedding method, the method is milder so that bioactive substances are prevented from damaging; the residual capsule core material in the solution after embedding can be recycled; the method is more environmentally-friendly, the originally reported particle size and pore diameter can be realized, the volume of the inner cavity is larger so as to facilitate the loading of the capsule core material; and the method is suitable for mass production.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to the molding processing of polymer microspheres and microcapsule materials and their application as novel pharmaceutical preparation materials. Background technique [0002] Microcapsules refer to small capsules ranging from submicron to millimeter scale. Functional materials and shell materials are the two basic elements that constitute microcapsules. The preparation of microcapsules refers to the process of preparing granular composites by encapsulating or dispersing functional materials in shell materials by certain methods. Microcapsules are an important commodity form. Many purposes can be achieved by embedding substances, such as improving the chemical or physical stability of the capsule core material, shielding the odor, color and toxicity of the capsule core, and realizing the controlled release and targeted release of the capsule core substance. Synthetic poly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K9/50A61K47/34
Inventor 马光辉高飞那向明苏志国
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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