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Method for preparing medical artificial bone material

A kind of bone and artificial technology, applied in the field of preparation of medical artificial bone materials, can solve the problems of high cost, complicated preparation process, chemical stability and weather resistance to be tested, and achieve the effect of enhancing strength and inhibiting the growth of germs

Active Publication Date: 2013-12-18
GUANGXI SHENGUAN COLLAGEN BIOLOGICAL GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above-mentioned various medical artificial bone materials are rich in types, most of them have complicated preparation process and high cost, some have poor biocompatibility and antithrombotic properties with the human body, and some have poor chemical stability in the human body. and weather resistance have yet to be tested, and the current concept of using graphene-enhanced polymethyl methacrylate to create medical artificial bones has never been used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The raw material mass percent of the medical artificial bone material of this embodiment is: graphene oxide 10%, acrylic acid 20% after acyl chloride, methyl methacrylate 68%, catalyst 1.2% and initiator 0.8%, all component mass The sum of the percentages is 100%.

[0020] The components of the above mass percentages are prepared according to the following steps for medical artificial bone materials:

[0021] (1) Disperse graphene oxide in acid-chlorinated acrylic acid, add it to the reaction kettle, and then add catalyst pyridine, in N 2 Under protection, after reacting at 80° C. for 4 hours, an esterified product was obtained.

[0022] (2) Add methyl methacrylate to the esterification product obtained in step (1), raise the temperature to 150°C, add the initiator methyl ethyl ketone peroxide, polymerize for 10 hours, cool to room temperature, and obtain a gray solid, which is the prepared Materials for medical artificial bones. Its properties are close to real huma...

Embodiment 2

[0024] The raw material mass percent of the medical artificial bone material of this embodiment is: graphene oxide 15%, acrylic acid 22% after acyl chloride, methyl methacrylate 61.4%, catalyst 0.8% and initiator 0.8%, all component mass The sum of the percentages is 100%.

[0025] The components of the above mass percentages are prepared according to the following steps for medical artificial bone materials:

[0026] (1) Disperse graphene oxide in acid-chlorinated acrylic acid, add it to the reaction kettle, and then add catalyst pyridine, in N 2 Under protection, after reacting at 100° C. for 5 hours, an esterified product was obtained.

[0027] (2) Add methyl methacrylate to the esterification product obtained in step (1), raise the temperature to 160°C, add the initiator methyl ethyl ketone peroxide, polymerize for 6 hours, cool to room temperature, and obtain a gray solid, which is the prepared Materials for medical artificial bones. Its properties are close to real hu...

Embodiment 3

[0029] The mass percentages of raw materials for the medical artificial bone material of this embodiment are: graphene oxide 7.2%, acrylic acid 12% after acyl chloride, methyl methacrylate 78.2%, catalyst 1.4% and initiator 1.2%, all component mass The sum of the percentages is 100%.

[0030] The components of the above mass percentages are prepared according to the following steps for medical artificial bone materials:

[0031] (1) Disperse graphene oxide in acid-chlorinated acrylic acid, add it to the reaction kettle, and then add catalyst pyridine, in N 2 Under protection, after reacting at 80° C. for 5 hours, an esterified product was obtained.

[0032] (2) Add methyl methacrylate to the esterification product obtained in step (1), raise the temperature to 140°C, add the initiator cyclohexanone peroxide, polymerize for 10 hours, cool to room temperature, and obtain a gray solid, which is the preparation obtained medical artificial bone materials. Its properties are clos...

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Abstract

The invention discloses a method for preparing a medical artificial bone material. Graphite flakes are used as raw materials, graphene oxide is prepared by adopting a Hummers oxidation method, crylic acidacyl is subjected to acyl chlorination, the graphene oxide is dispersed in a crylic acidacyl solution after the acyl chlorination, the solution is added into a reaction kettle, then a catalyst is added into the reaction kettle for pyridine, and under the protection of nitrogen, the reaction lasts for 3-5 hours to obtain an esterification product. Methyl methacrylate is added into the esterification product, temperature is raised to 100-200 DEG C, an initiating agent is added in the esterification product to perform polymerization for 5-10 hours, and then cooling the esterification product to room temperature to obtain a gray solid body, namely the medical artificial bone material. The initiating agent is one of cyclohexanone peroxide and methyl ethyl ketone peroxide. The method for preparing the medical artificial bone material is low in production cost and simple in reaction, and the grapheme remarkably improves strength of the medical artificial bone material and does not influence compatibility of artificial bones and human-body biological tissues while restrains growth of germs.

Description

Technical field: [0001] The technical field of the invention belongs to the fields of polymer chemistry, polymer physics, biochemistry, synthetic material technology and material chemistry, and particularly relates to a preparation method of a medical artificial bone material. Background technique: [0002] Medical polymer materials are an important part of biomedical materials, mainly used in medical fields such as artificial organs, surgical repair, physical therapy rehabilitation, diagnostic examination, and disease treatment. As we all know, organisms are the most basic form of organic polymers, and organic polymers are the basis of life. The most important substances in the composition of animals and plants - protein, muscle, cellulose, starch, biological enzymes and pectin are all polymer compounds. Therefore, it can be said that the biological world is a huge source of natural polymers. The ubiquity of polymer compounds in the biological world determines their speci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/14C08F220/06C08K9/00C08K3/04C08L33/12A61L27/44A61L27/50
Inventor 徐旭郭栋刘括
Owner GUANGXI SHENGUAN COLLAGEN BIOLOGICAL GRP CO LTD