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Method for preparing degradable magnesium-doped amorphous calcium phosphate coating on surface of titanium implant

A titanium implant, amorphous technology, applied in the field of bioactive magnesium ion doped amorphous calcium phosphate coating, can solve the problems of unrealized ACP coating, and achieve the promotion of biological activity and degradability, rapid degradation and absorption , The process is simple and controllable

Inactive Publication Date: 2012-06-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the technology to prepare stable and uniform and controllable ACP coatings by this method has not yet been realized.

Method used

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  • Method for preparing degradable magnesium-doped amorphous calcium phosphate coating on surface of titanium implant
  • Method for preparing degradable magnesium-doped amorphous calcium phosphate coating on surface of titanium implant
  • Method for preparing degradable magnesium-doped amorphous calcium phosphate coating on surface of titanium implant

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Embodiment 1

[0019] In this embodiment, the method for preparing a degradable magnesium ion-doped amorphous calcium phosphate coating on the surface of a sandblasted acid etching (SLA) titanium implant using an electrochemical method is as follows:

[0020] (1) Prepare the electrolyte of the constituent elements of ACP. The constituent elements of ACP are CaCl 2 , NH 4 H 2 PO 4 And MgCl 2 ·2H 2 O provided, Ca 2+ The concentration is 12×10 -3 M, PO 4 3- The concentration is 7.2×10 -3 M, Mg 2+ The concentration is 2.4×10 -3 M, Mg 2+ With Ca 2+ The molar concentration ratio is 1:5. Dissolve the analytically pure reagents one by one in distilled water according to the above concentration requirements, and vibrate ultrasonically for 30 minutes.

[0021] (2) Add the electrolyte described in step (1) into a container equipped with a constant temperature heating system, and heat the electrolyte to 60° C. and then maintain a constant temperature.

[0022] (3) Using platinum as the anode and metal titaniu...

Embodiment 2

[0026] In this embodiment, the method of electrochemically preparing a degradable magnesium ion-doped amorphous calcium phosphate coating on the surface of a sandblasted acid etching (SLA) titanium implant is as follows:

[0027] (1) Prepare the electrolyte of the constituent elements of ACP. The constituent elements of ACP are CaCl 2 , NH 4 H 2 PO 4 And MgCl 2 ·2H 2 O provided, Ca 2+ The concentration is 6×10 -3 M, PO 4 3- The concentration is 3.6×10 -3 M; Mg 2+ The concentration is 2×10 -3 M, Mg 2+ With Ca 2+ The molar concentration ratio of is 1:3. Dissolve the analytically pure reagents one by one in distilled water according to the above concentration requirements, and vibrate ultrasonically for 30 minutes.

[0028] (2) Add the electrolyte described in step (1) into a container equipped with a constant temperature heating system, and heat the electrolyte to 35° C. and then maintain a constant temperature.

[0029] (3) Use platinum as the anode and metal titanium substrate as th...

Embodiment 3

[0033] The degradable magnesium ion-doped amorphous calcium phosphate coating prepared by the electrochemical method on the surface of the sandblasted acid etching (SLA) titanium implant according to the present invention includes the following steps:

[0034] (1) Prepare the electrolyte of the constituent elements of ACP. The constituent elements of ACP are CaCl 2 , NH 4 H 2 PO 4 And MgCl 2 ·2H 2 O provided, Ca 2+ The concentration is 36×10 -3 M, PO 4 3- The concentration is 21.6×10 -3 M, Mg 2+ The concentration is 9×10 -3 M, Mg 2+ With Ca 2+ The molar concentration ratio of is 1:4. Dissolve the analytically pure reagents one by one in distilled water according to the above concentration requirements, and vibrate ultrasonically for 30 minutes.

[0035] (2) Add the electrolyte described in step (1) into a container equipped with a constant temperature heating system, and heat the electrolyte to 35° C. and then maintain a constant temperature.

[0036] (3) Use platinum as the anode a...

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Abstract

The invention discloses a method for preparing a degradable magnesium-doped amorphous calcium phosphate coating on surface of a titanium implant, which is characterized in that in an electrolyte under a constant temperature state with the temperature of 35-60 DEG C, platinum is taken as anode and a metallic titanium matrix is taken as a cathode, a cathode reduction reaction is carried out on the surface of the metallic titanium matrix, thereby a layer of uniform magnesium ion-doped amorphous calcium phosphate coating is deposited on the surface of the metallic titanium matrix; wherein, the electrolyte contains elements constituting amorphous calcium phosphate and Mg<2+>, and the mole concentration ratio of Ca<2+> to PO4 <3-> is 1.67:1, the mole concentration ratio of Mg<2+> to Ca<2+> is 1:5-1:3, and the direct current voltage between anode and cathode is 3.0-3.6 V. The prepared coating of the invention is uniform, the process is simple and controllable, and the prepared coating possesses excellent biological inducibility and fast degradation rate. In addition, the amorphous calcium phosphate can be stabilized by doping trace element Mg, the Mg<2+> in the coating is capable of raising the biological activity and promoting the growth of bone tissue.

Description

Technical field [0001] The invention relates to a degradable bioactive magnesium ion doped amorphous calcium phosphate coating deposited on the surface of a titanium implant by an electrochemical method, and belongs to the field of biomedical materials. Background technique [0002] In the biologically active calcium phosphate system, amorphous phosphate calcium (ACP) is widely present in the newborn tissues of animals and humans. It is more than hydroxyapatite (HAP) and octacalcium phosphate (ACP). OCP) and other crystalline substances have better biological activity and induction properties. As a biomedical material, it can induce the growth of its own tissue more quickly in the early stage of healing, and can be quickly degraded and absorbed. If it is prepared as a coating and coated on the surface of the implant, it will rapidly degrade and absorb while inducing the growth of new tissue, so that the new tissue will directly form a mechanical occlusion with the surface of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/08A61L27/32A61L27/06
Inventor 张小娟林东洋王小祥
Owner ZHEJIANG UNIV
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