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An'erning medicinal composition buccal tablet and preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, non-active ingredients of polymer compounds, etc., can solve the problem of affecting the absorption and utilization of active ingredients of drugs, slow release of active ingredients of raw materials, excessive dosage of granules, etc. problem, to achieve the effect of improving lobes, good taste and convenience, and improving bioavailability

Active Publication Date: 2012-07-04
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Anering preparation has good curative effect and broad market prospect. Pharmacological and pharmacological research results show that it has good curative effect on cough with phlegm, fever and sore throat. At present, the dosage of granules is too large and has a certain pungent smell.
[0004] The traditional method is used in the preparation of the existing Anering drug, and the active ingredient of the raw material drug is released slowly, which seriously affects the absorption and utilization of the active ingredient of the drug.

Method used

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  • An'erning medicinal composition buccal tablet and preparation method and application thereof
  • An'erning medicinal composition buccal tablet and preparation method and application thereof
  • An'erning medicinal composition buccal tablet and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0049] Experimental Example 1, Prescription Screening Experiment

[0050] 1. Screening experiment of fillers:

[0051] (1) Add Anering extract, artificial bezoar bezoar β-cyclodextrin inclusion compound, volatile oil β-cyclodextrin inclusion compound, add mannitol as filler, add aspartame as corrective agent, use Granulated with 80% ethanol, dried, sized, mixed evenly, added with micropowder silica gel and magnesium stearate, and compressed into tablets. As a result, there is a split phenomenon.

[0052] (2) Add pregelatinized starch to the prescription of (1) to improve the cracking phenomenon.

[0053] If mannitol is added alone in the composition, cracking phenomenon will occur. In order to improve the cracking phenomenon, pregelatinized starch is added as filler while adding mannitol, and the mass ratio relationship is investigated. The experimental results are shown in Table 1.

[0054] Table 1 Screening result table of filler

[0055]

[0056] The experimental re...

experiment example 2

[0075] Experimental example 2, extraction process screening experiment

[0076] 1. Amount of water added and extraction time

[0077] The original process of Anning Granules only reflects the extraction of volatile oil, and the specific extraction method, extraction temperature, extraction time and extraction rate of volatile oil are not specified. For this reason, the above-mentioned factors have been investigated in the process optimization process of the present invention.

[0078] According to the proportion of the prescription, accurately weigh 53.3g of safflower and 66.7g of white sandalwood, put them in a 2000ml round bottom flask, add 3, 5, 8, and 10 times the amount of water respectively, soak for 3 hours, and extract volatile oil for 5 hours, the results are shown in the table 5.

[0079] Table 5 water addition test results

[0080]

[0081] Conclusion: The results show that when adding 3 times the amount of water, the oil yield is 0.38ml, and when adding 5 time...

Embodiment 1

[0112] A kind of Anerning buccal tablet is made from the following raw and auxiliary materials in parts by weight:

[0113]

[0114] Prepared as follows:

[0115] (1) Preparation of Anering extract: get safflower 53.3g, white sandalwood 66.7g, add water 600g, extract by steam distillation for 3 hours, collect safflower, white sandalwood volatile oil, set aside, filter, and the obtained medicinal residue and Combine 53.3g of licorice, 53.3g of alpine horseradish, 53.3g of rock cabbage, 66.7g of Tianzhuhuang, 66.7g of short ear grass and 66.7g of Tangut aconitum, add water to extract twice at 90°C, add medicine residue for the first time With water 10 times the total weight of the 6 medicinal materials, decoct for 3 hours, add medicinal residues and water 8 times the total weight of the 6 medicinal materials for the second time, decoct for 2 hours, filter, combine the filtrates, and concentrate To the clear paste with ρ=1.02 at 50°C, refrigerate the clear paste at 4°C for 24...

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Abstract

The invention relates to an an'erning medicinal composition buccal tablet, and a preparation method and application thereof. The an'erning medicinal composition buccal tablet is prepared from the following Chinese herbal medicines in part by weight: 20 to 40 parts of an'erning extract, 0.2 to 1 part of volatile oil beta-cyclodextrin clathrate compound, 15 to 30 parts of calculus bovis factitius beta-cyclodextrin clathrate compound, 1 to 2 parts of menthol crystal absolute ethanol solution, 20 to 30 parts of mannitol, 10 to 15 parts of pregelatinized starch, 1 to 3 parts of sucralose, 0.5 to 1part of superfine silica powder and 1 to 2 parts of magnesium stearate. According to the an'erning medicinal composition buccal tablet, volatile oil ingredients in formula medicinal materials are extracted; by utilizing a beta-cyclodextrin clathration process, the stability and bioavailability of the medicine are improved, the absorption of the medicine is promoted, and the conventional administration mode of an'erning granules is changed; and the buccal tablet medicine can reach the parts of a throat, is quickly absorbed, and is taken transbuccally, so that the medicine can be kept at the throat for a long time to exert a medicinal effect continuously.

Description

technical field [0001] The invention relates to a Tibetan medicine composition, in particular to a pharmaceutical composition An'erning buccal tablet and its preparation method and application. Background technique [0002] Anerning Granules are recorded in the national drug standard part of the rising local standard of Chinese patent medicine; standard number: WS-10640(ZD-0640)-2002. The prescription is as follows: Tianzhuhuang 66.7g, safflower 53.3g, artificial bezoar 5.3g, rock cabbage 53.3g, licorice 53.3g, alpine horseradish 53.3g, short-eared rabbit ear grass 66.7g, white sandalwood 66.7g, Tangut aconitum 66.7g, 930g of sucrose to make 1000g. The traditional preparation method of Anning Granules is as follows: the above nine medicinal materials, in addition to artificial bezoar, extract volatile oil from white sandalwood and safflower, collect them in another device, add the residue and other six medicinal materials such as rock cabbage, and decoct them twice with wate...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K47/40A61K9/20A61P11/10A61P11/14A61P31/00A61P11/00A61P11/04A61P29/00
Inventor 常建晖马宏伟杨敬燕赵丽丽李丽
Owner JINHE TIBETAN MEDICINE
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