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Blood displacement foundation liquid and preparation method

A technology of blood replacement and base fluid, applied in the fields of blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., can solve the problems of reducing the anticoagulation effect of the replacement base fluid, unstable blood calcium ion concentration, and physiological dysfunction of patients, etc. The effect of preventing hypocalcemia, good anticoagulant effect, and saving clinical operation steps

Active Publication Date: 2012-07-18
CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because, if calcium ions and citrate ions are placed in the same replacement base solution, calcium ions and citrate ions will form complexes that are not easily dissociated, reducing the anticoagulant effect of the replacement base solution
[0005] At present, when using the existing replacement base fluid, in order to prevent hypocalcemia in patients, it is necessary to supplement calcium ions from the peripheral vein at the same time, which increases the operation steps in the treatment process, and when this method is used to supplement calcium ions, the patient The blood calcium ion concentration is still not stable enough, which will directly lead to physiological dysfunction of patients, and even death in severe cases. Therefore, there are still certain risks in the clinical use of the existing replacement base fluid.

Method used

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  • Blood displacement foundation liquid and preparation method
  • Blood displacement foundation liquid and preparation method
  • Blood displacement foundation liquid and preparation method

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Embodiment 1

[0035] Embodiment 1 Preparation of blood replacement base fluid of the present invention

[0036] Take 10 moles of anhydrous glucose, 100.7 moles of sodium chloride, 0.75 moles of magnesium chloride hexahydrate, 1.4 moles of calcium chloride dihydrate, and 9 moles of sodium citrate dihydrate, dissolve them in 400 liters of water for injection, and then add activated carbon for adsorption. Filter with a 0.45 μm titanium rod, add water for injection to 1000 liters, filter through a 0.22 μm terminal filter, fill it into a PVC infusion bag with a capacity of 4000 ml, seal it, and sterilize at 115 degrees Celsius for 30 minutes to obtain the product.

[0037] In the prepared replacement base solution, the concentration of each component is shown in Table 1:

[0038] Table 1

[0039]

[0040] Note *: The physiological concentration here refers to the concentration of free electrolytes in the extracellular fluid components (mainly serum) of the human physiological body.

[0041]...

Embodiment 2

[0042] Embodiment 2 The screening of the concentration of each component in the blood replacement base fluid of the present invention

[0043] The principle of citrate anticoagulation is that citrate complexes free calcium ions in the blood at 1:1 to block the blood coagulation chain. Or the content of sodium citrate should be at least greater than the sum of the calcium content in the replacement base fluid and the amount of free calcium ions in the mixed blood during use. Application in replacement therapy, China Blood Purification, 2005, 4(1): 42], the amount of replacement base fluid is mostly 2000-4000 ml / hour, and the blood flow is mostly 120-160 ml / min. Based on this calculation, the replacement base The citrate contained in the solution should at least be able to complex and replace the calcium content in the base solution (0.225 mmol / L), and the amount of free calcium ions in the corresponding blood (the highest is: the upper limit of the concentration of free calcium...

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Abstract

Blood displacement foundation liquid comprises calcium ions and citron acid radicals, wherein according to the content in each liter of injection water, citron acid radicals are 5 to 15 mmol and calcium ions are 1.2 to 1.8 mmol. The invention further provides a preparation method of the blood displacement foundation liquid. The blood displacement foundation liquid is provided with the calcium ions based on existing citric acid anticoagulation displacement liquid. Even though the added calcium ions complexes a part of the citron acid radicals, the blood displacement foundation liquid is enabled to have good anticoagulation effects by adjusting adding amount of the calcium ions and effectively prevent hypocalcemia. Calcium ions are not required to be inputted additionally from peripheral veins so as to save clinical operation steps. Simultaneously, the blood displacement foundation liquid can guarantee stability of the level of blood serum osteocalcin of patients, thereby avoiding remarkable large fluctuation of the level of the blood serum osteocalcin and reducing clinical risks.

Description

technical field [0001] The invention relates to a blood replacement base fluid and a preparation method thereof. Background technique [0002] Blood purification therapy, especially continuous blood purification therapy, is one of the main treatment measures for critically ill patients today, and is as important as mechanical ventilation and total parenteral nutrition therapy. This technology can enable patients with multiple organ failure to undergo replacement therapy for renal or non-renal diseases smoothly. Acute respiratory distress syndrome (ARDS) and acute necrotizing pancreatitis play an increasingly important role. The technology mainly includes continuous venous-venous hemofiltration (CVVH); continuous arterial-venous hemodialysis (CAVHD) and continuous venous-venous hemodialysis (CVVHD); continuous arterial-venous hemodiafiltration (CAVHDF) And continuous veno-venous hemodiafiltration (CVVHDF); slow continuous ultrafiltration (SCUF); continuous high-flow dialysi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/194A61K33/14A61P7/08A61K31/7004A61K33/06
CPCA61K33/06A61K31/7004A61K31/194A61K33/20A61K9/0026A61K33/14A61P7/08A61K2300/00
Inventor 徐世兰杨炯崔盛
Owner CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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