29 results about "Peripheral veins" patented technology

The invention discloses a peripheral vein puncture blood vessel pressure monitoring system for image enhancement examination based on multi-modal fusion, and relates to the technical field of medical image assistion.The peripheral vein puncture blood vessel pressure monitoring system comprises the steps that image data, sensor data and personalized data of a patient are collected; generating an image feature vector, a sensor feature vector and a personalized feature vector based on the preprocessed multi-modal data, carrying out feature interaction on a multi-modal feature line, carrying out representation fusion by combining Transform with contrast learning, and generating a fusion representation vector; the maximum tolerance pressure, the extravasation risk level and the recommended injection flow rate range of the target puncture point under the current injection flow rate are predicted and evaluated in the blood vessel pressure resistance prediction model, injection suggestions and injection alarms of the target puncture point are generated, and injection parameters are automatically adjusted. According to the method, the personalized safety pressure threshold values of patients with different blood vessel conditions are accurately evaluated, and the safety and accuracy of peripheral vein puncture are remarkably improved.

The invention relates to the field of preparation of CD19 targeted CAR-T cells, in particular to an adjustable CD19 targeted CAR-T cell preparation technology which comprises the following operation steps: S1, T cell collection and separation: S1.1, peripheral blood collection: blood is collected from peripheral veins of a patient, and the general collection amount is determined according to the physical condition of the patient and the amount required by subsequent cell culture and is usually between 50ml and 500ml; s1.2, performing density gradient centrifugal separation on the T cells; s2, CAR gene construction and carrier preparation: S2.1, CAR structure design (taking an inducible promoter system as an example), CD19 targeting CAR-T cells can accurately recognize and combine CD19 antigens on the surfaces of tumor cells, and as CD19 is highly expressed on the surfaces of most blood system malignant tumor cells such as B cell lymphoma and leukemia and is limited in expression in normal tissue cells, the CD19 targeting CAR-T cells can be used for accurately recognizing and combining the CD19 antigens on the surfaces of the tumor cells. Therefore, the CAR-T cells can specifically attack tumor cells like a'biological missile ', and damage to normal tissues is reduced.

The utility model relates to a peripheral vein indwelling needle which comprises a puncture needle assembly and an indwelling needle seat, the indwelling needle seat is of a tubular structure with two open ends, a sealing plug is installed in one end of the indwelling needle seat, the other end of the indwelling needle seat is fixedly communicated with an indwelling catheter, and the puncture needle assembly comprises a puncture needle seat. The puncture needle seat is located outside the end, away from the indwelling catheter, of the indwelling needle seat and is of a transparent tubular structure, one end of the puncture needle seat is open and provided with a detachable sealing cap, the other end of the puncture needle seat is closed, and a blood return cavity is formed between the other end of the puncture needle seat and the sealing cap. The closed end of the puncture needle base is fixedly connected with a puncture needle communicated with the interior of the blood return cavity, one end of the puncture needle is a tip end, the tip end of the puncture needle sequentially penetrates through the sealing plug and the indwelling catheter and then is located outside the indwelling catheter, and the puncture needle is in sliding connection with the sealing plug and the indwelling catheter. According to the indwelling needle, the time for medical staff to judge whether the indwelling needle is punctured into the venous blood tube of a patient or not can be shortened, so that the working efficiency of the medical staff is improved.

To provide a method of administering peptide receptor radionuclide therapy for neuroendocrine tumours while minimizing gastrointestinal adverse side effects and reducing kidney function deterioration.SOLUTION: The present invention emphasizes on the use of lutetium-177 (177 Lu)-DOTATOC as a radiotherapeutic agent and arginine as the sole kidney protective agent, and intravenous infusion of the 177 Lu-DOTATOC and arginine through separate infusion lines onto different peripheral veins on opposite hands, in which the subject receiving the method of administration according to the present invention exhibits significantly and effectively reduced development of any gastrointestinal adverse events, enabling safe protection of kidneys from treatment-related injury.SELECTED DRAWING: Figure 3

The utility model belongs to the technical field of clinical nursing, and particularly relates to a peripheral vein central catheter dressing change support which comprises two first supporting rods and two second supporting rods, the middle portions of the two first supporting rods are correspondingly hinged to the middle portions of the two second supporting rods to form two fork-shaped structures, and the two fork-shaped structures are connected with the first supporting rods and the second supporting rods. A bearing rod is arranged between the upper ends of the two first supporting rods, a bearing rod is arranged between the upper ends of the two second supporting rods, and the two bearing rods are used for bearing arms of a patient. The telescopic mechanism is used for adjusting the included angle between the first supporting rod and the second supporting rod in the two fork-shaped structures. The puncture position and skin around the puncture position can be in a completely exposed state without manually turning or lifting the arm of a patient by a nurse, the nurse can directly clean and disinfect the skin around the puncture position in all directions, the operation convenience and efficiency are improved, the whole body can be folded, and the operation is convenient. Nursing personnel can conveniently carry along with other instruments or operation articles and go to wards for use, labor is saved in use, and flexibility is higher.

The invention relates to a device and method for fluid delivery through a placed peripheral venous catheter. An apparatus includes a catheter, an introducer, and an actuator. The distal end portion of the introducer is configured to be coupled to an indwelling peripheral vein line. An actuator is movably coupled to the introducer and configured to move the catheter between a first position in which the catheter is disposed within the introducer and a second position in which the distal portion of the catheter is distal to the introducer. A first portion of the actuator is disposed outside the introducer and in contact with an outer surface of the introducer such that: a longitudinal axis defined by a second portion of the actuator is not parallel to a longitudinal axis defined by the introducer; the second portion of the actuator exerts a force on the proximal end portion of the catheter to increase internal stress within a portion of the catheter.

The invention relates to the field of molecular biology, in particular to a composition and a kit for detecting COX20 gene polymorphism and application of the composition and the kit. The SNP site of the COX20 gene of genome DNA in a human peripheral vein whole blood sample is determined by an ARMS-PCR fluorescent probe line method, and the genotype is tested and judged by two parallel tubes. Compared with a first-generation and second-generation sequencing method and other methods, the method has the advantages of simplicity in operation, low cost, short detection time and the like.

This invention is directed to compositions comprising bisantrene, particularly formulations of bisantrene dihydrochloride, wherein the formulations are suitable for intravenous administration into peripheral veins as well as methods for their use and methods for preparation of such compositions. The compositions according to the present invention eliminate the need to administer bisantrene by central venous catheter administration. The compositions can be used to treat malignancies and other conditions, and may be used for cardioprotection in patients undergoing chemotherapy with anthracycline-based anti-neoplastic agents. The inclusion of α-hydroxy acids in compositions according to the present invention improves the stability of such compositions and prevents precipitation of the bisantrene.

A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.

The utility model relates to a peripheral venous pressure monitoring device which comprises a hose (1) and an infusion nipple (2) arranged at the bottom end of the hose (1) and used for being connected with an indwelling needle, a closed normal saline storage portion (3) is arranged in the hose (1), and scales (4) are arranged on the side wall, located below the normal saline storage portion (3), of the hose (1). And the hose (1) is provided with a telescopic turning part (10) below the scales (4). Compared with the prior art, the peripheral venous pressure monitoring device provided by the utility model is convenient for medical staff to operate, and is convenient to carry and operate. When the disposable puncture needle is used, puncture operation is not needed, and pain of a patient is relieved. The pre-sealed normal saline also reduces the possibility of contamination during operation. And the bent part of the hose can be effectively prevented from being blocked, and data are more reliable and easy to obtain.

The invention discloses a perigastric vein segmentation and varicosity quantification method. The method comprises the following steps: S1, constructing a segmentation network of an anatomical prior path and a vein segmentation path to perform vein tissue segmentation; s2, extracting a vein contour based on a vein tissue segmentation result, calculating a maximum inscribed circle diameter of a vein through a scale adaptive fitting strategy, and realizing accurate conversion and correction of a physical size in combination with a pixel pitch in a medical image Dicom format; and S3, deploying a multi-condition constraint module at the tail end of the segmentation network, integrating vein morphological feature analysis, vein contrast enhancement processing and clinical anatomical standard verification, screening vein segments conforming to varicose vein features through a multi-dimensional scoring function, and optimizing a vein segmentation result. An intelligent and automatic solution is provided for the detection of the perigastric varicose veins, the technical development in the field of medical image analysis is promoted, and the application of AI in clinical diagnosis is further promoted.

The present invention discloses a PICC catheterization ultrasonic puncture positioning system, belonging to the technical field of medical devices. A PICC catheterization ultrasonic puncture positioning system includes a data collection module, an identification model, and a positioning module. The present invention solves the problem that the prior art may be affected by factors such as environmental light and spatial layout, affecting its accuracy and practicability. The present invention uses Mel Frequency Cepstral Coefficients for PICC catheterization positioning, which can extract more accurate acoustic wave features, effectively identify and locate the acoustic wave signals of PICC catheterization, thereby improving the positioning accuracy, effectively reducing the interference of background noise on PICC catheterization positioning, improving the accuracy of positioning, ensuring the smooth delivery of drugs, improving the therapeutic effect of drugs, avoiding damage to surrounding tissues, reducing the occurrence of complications such as phlebitis and infection, and protecting the patient's peripheral veins from being corroded by chemotherapy drugs.

The invention discloses a tumor metastasis risk assessment method and system based on circulating tumor DNA (ctDNA) spatial heterogeneity. The core of the method is as follows: blood samples of at least two different anatomical sites (such as peripheral veins and tumor drainage veins) of the same subject are obtained at the same time, and ctDNA in the samples is subjected to sequencing analysis; calculating characteristic data (such as a relative abundance ratio) representing ctDNA spatial distribution based on the mutation abundance difference between different parts; and finally, inputting the feature data into a pre-trained metastasis risk assessment model, and outputting a quantitative tumor metastasis risk score. According to the method, the limitation of traditional single-point liquid biopsy is broken through, the detection sensitivity of tiny metastases can be remarkably improved by utilizing the spatial distribution information of the ctDNA, potential metastasis positioning information is provided, and powerful technical support is provided for accurate diagnosis and treatment decision of tumor patients.

The invention relates to the technical field of medical auxiliary instruments, in particular to an auxiliary positioning device for peripheral vein puncture, which comprises a linear motor, a positioning frame and a controller, the positioning frame is fixedly arranged on a rotor of the linear motor, the positioning frame is used for assisting vein positioning puncture, the controller is arranged on one side of a shell of the linear motor, and the controller is arranged on the other side of the shell of the linear motor. The controller is externally connected with display equipment; the positioning frame comprises a sliding block, an arc-shaped frame and an arc-shaped plate, the sliding block is fixedly connected to a rotor of the linear motor, the arc-shaped frame is rotationally connected to the sliding block, and the arc-shaped plate is fixedly arranged on the arc-shaped frame. The positioning frame is driven by the linear motor to move horizontally, the mounting block is driven by the servo motor to slide back and forth along the arc-shaped frame, the ultrasonic probe can be automatically attached to the limb curved surface for systematic scanning, and full-level and multi-dimensional vein development from subcutaneous superficial layer to deep layer blood vessels is achieved in cooperation with the ultrasonic probe and the near-infrared optical module.

The invention relates to the technical field of molecular biology, in particular to a composition and a kit for detecting ATP7B gene polymorphism and application of the composition and the kit. According to the present invention, the common SNP site of the hepatolenticular degeneration pathogenic gene ATP7B of the genome DNA in the human peripheral vein whole blood sample is determined by using the PCR-fluorescent probe melting curve method, such that the multiple detection in the single tube can be achieved compared with the traditional PCR-SNP detection method so as to substantially improve the detection flux; compared with a first-generation and second-generation sequencing method and other methods, the method has the advantages of simplicity in operation, low cost, short detection time and the like.

The utility model provides a peripheral vein catheterization limb fixator which comprises a supporting base, a first bevel gear, a pedal wheel, a second bevel gear, a lead screw, a connecting assembly and a bearing pad, and a containing space is formed in the supporting base; the first bevel gear is rotatably arranged in the accommodating space, and a threaded hole is formed in the middle of the first bevel gear; the pedal wheel is rotatably arranged on the supporting base in a penetrating manner and extends into the accommodating space; the second bevel gear is arranged in the accommodating space and connected with the pedal wheel, and the second bevel gear is meshed with the first bevel gear; the lead screw is arranged on the supporting base in a penetrating mode in the vertical direction, and the lead screw is arranged in the threaded hole in a penetrating mode and matched with the threaded hole in a threaded mode. The connecting assembly is connected with the screw rod; the bearing pad is arranged on the connecting assembly in the mode that the angle can be rotationally adjusted, a U-shaped groove used for bearing the wrist of the patient is formed in the bearing pad, and a bandage is arranged in the U-shaped groove. The device can replace an assistant, and can assist an operator to independently disinfect the upper arm of a patient and fix the punctured limb.

The present invention discloses a peripheral venous protection stent, comprising a rotary cutting element, an ejection tube, an inner tube, a cannula funnel, a loading sheath, and an outer sheath tube, characterized in that: the rotary cutting element comprises a grinding section, a straight section, and a funnel section; the proximal end of the rotary cutting element is closed on the ejection tube, the rotary cutting element is a closed mesh cage structure, and the distal end of the rotary cutting element is a circular ring and extends to the straight section to form a closed design. The cannula funnel can be used alone or in conjunction with the rotary cutting element. The peripheral venous protection stent can avoid the risk of pulmonary embolism caused by thrombus production due to long-term catheterization during central venous catheterization via peripheral venous puncture; at the same time, it can avoid the risk of thrombus detachment during other interventional surgeries such as peripheral vascular thrombectomy and peripheral stent implantation.

The present invention provides a two-liquid mixture type infusion preparation in which precipitation is unlikely to occur even due to a change in composition upon addition of a calcium ion correction liquid. Provided as a solution is an infusion preparation which is for administration to a peripheral vein, which has two chambers that are separated by a partition that allows for communication, in which a first chamber infusion containing an amino acid is accommodated in a first chamber, and in which a second chamber infusion containing a sugar is accommodated in a second chamber, wherein a liquid mixture of the first chamber infusion and the second chamber infusion has (A) a pH of not more than 6.4 and (B) contains an organic acid in a total amount of not less than 3 mEq / L.

The invention relates to the technical field of venous indwelling catheter puncture navigation, and discloses a central venous indwelling catheter puncture auxiliary system through peripheral vein puncture. According to the system, an ultrasonic image and a dissection description text are acquired through a data acquisition and verification module; a three-dimensional blood vessel modeling module is used for carrying out spatial registration on the two blood vessels, and a three-dimensional blood vessel model containing semantic information is constructed; the anatomical variation analysis module is compared with a standard map, a variation region is automatically marked, and the puncture feasibility is evaluated; the puncture path planning module generates a target path in the feasible blood vessel model in combination with the instrument parameters, and decomposes the target path into executable steps associated with real-time ultrasonic features and specific operation instructions; and finally, the path conflict detection and navigation control module carries out calibration and sends an instruction to control the puncture auxiliary device to align. According to the method, a closed loop from objective evaluation of multi-source information fusion to programmed step navigation is realized, and the dependence on personal experience and spatial imagination of an operator is reduced.

The invention belongs to the field of biological medicine, and particularly relates to a targeted medicine for treating prostatic cancer and application thereof. The drug is an Apt-C-C-S-PEG-CHO anchored 293T exosome loaded with siRNA-JAG1 and siRNA-NOTCH3, the drug with an optimized molar ratio can target prostate cancer cells through peripheral veins, and the malignant progression of the prostate cancer can be more effectively inhibited.

The invention discloses a targeted retina drug-loaded extracellular vesicle as well as a preparation method and application thereof. The targeted retina drug-loaded extracellular vesicle comprises a lactobacillus-derived extracellular vesicle and a retina ischemia-reperfusion injury related disease treatment drug loaded in the extracellular vesicle, the medicine for treating the diseases related to the retinal ischemia reperfusion injury is indolepropionic acid; the loading capacity of the targeted retina drug-loading extracellular vesicle to indolepropionic acid is (6-8) * 10 <-8 > microgram / particle. The drug-loaded extracellular vesicle has the advantages of high drug loading rate, good biocompatibility, good gastrointestinal tract stability, high bioavailability and good safety. Besides, the extracellular vesicles loaded with indolepropionic acid can carry related marker proteins of retinal neurons through a membrane fusion technology, and can reach an eye retina area more efficiently through peripheral vein administration.

The invention relates to a bending-adjustable guide cannula for pulmonary artery interventional therapy. The bending-adjustable guide cannula comprises an outer sheath and an inner tube, the sheath is long enough to penetrate through the heart from the peripheral vein to be communicated to the pulmonary artery; the far end of the outer sheath is arranged to be a first bending part B with the inherent bending angle ranging from 80 degrees to 100 degrees. The inner tube is slidably arranged in the outer sheath in a penetrating mode, and the far end of the inner tube is provided with an inner tube bending adjusting section capable of being controlled to deflect through a pull wire; and the bending part is a second bending part A. By adjusting the handheld part, the axial distance between the two bending points of the fixed bend B and the adjustable bend A can be dynamically changed, in combination with the 360-degree rotating capacity of the inner tube and fine control over the angle of the bend adjusting section through the rotary knob, an operator can construct various composite bends in real time in the operation, pulmonary artery branch openings originating from different angles are accurately anchored, and the operation efficiency is improved. And a strong active supporting force is provided.

The freeze-dried powder injection can effectively control postoperative recurrence of tumors. The freeze-dried powder injection is advanced in preparation process, low in cost, free of pollution and high in effective component extraction rate. The freeze-dried powder injection preparation process is advanced, and trace heat source substances (allergic substances) in the injection can be effectively removed. In the formula of the freeze-dried powder injection, the anti-cancer active ingredient bufonin cantharidin of the venenum bufonis cantharides is unstable in the injection, so that the consistency of the anti-cancer curative effect is difficult to guarantee, and various active ingredients in the freeze-dried powder injection are stable. And the stability investigation accords with pharmacopoeia regulations. The injection prepared from the venenum bufonis and the cantharides has serious irritation to peripheral veins, and the freeze-dried powder has no irritation to the peripheral veins.

The invention relates to the technical field of medical instruments for human body oxygen supply, in particular to a human body vein oxygen therapy device and an oxygen therapy method. The human body vein oxygen therapy device comprises an oxygen source, an oxygen therapy tube, a flow velocity regulating valve, a flow velocity detecting device and a body entering tip, the oxygen source is connected with the tip end of the body through the oxygen catheter, pure oxygen is input into veins of the human body, and pure oxygen bubbles which are not wrapped by other substances and are in direct contact with blood are formed in the blood; and a flow rate regulating valve and a flow rate detection device are arranged on the oxygen catheter. According to the human body vein oxygen therapy method, pure oxygen is directly input into the human body vein to form oxygen bubbles, the oxygen bubbles are combined with hemoglobin in the blood flowing process of the peripheral vein, the body vein, the vena cava, the right atrium and the right ventricle of the human body, and the size and the number of the pure oxygen bubbles are controlled through the flow rate adjusting valve. Pure oxygen is directly input into veins of a human body to supply oxygen to the human body, a new mode for supplying oxygen through the veins of the human body is provided, cost is low, and efficiency is high.

The invention belongs to the field of biological medicine, and particularly relates to a targeted medicine for treating prostatic cancer and application thereof. The drug is an Apt-C-C-S-PEG-CHO anchored 293T exosome loaded with siRNA-JAG1 and siRNA-NOTCH3, the drug with an optimized molar ratio can target prostate cancer cells through peripheral veins, and the malignant progression of the prostate cancer can be more effectively inhibited.

The utility model provides a kind of for peripheral vein blood sampling ultrasonic probe positioning support, including support, crossbeam, regulator. Support is made of two symmetrical supports, and support includes bottom bar and vertical rod, and adjusting vertical groove is provided on vertical rod, and crossbeam is placed between two vertical rods, and ultrasonic probe slot is equipped in the middle of crossbeam, and positioning pipe is fixed in end part, and positioning pipe is movably inserted in adjusting vertical groove. Regulator is configured at the both ends of crossbeam, and the adjustment of the position of crossbeam is realized by the pushing of pressing rod, and the accurate positioning of ultrasonic probe is ensured. By anti-skid gasket, silica gel soft pad and cross insertion rod structure, it is ensured that support is stable and convenient to store and transport. It can be fine-tuned according to the arm shape of different patients, provide accurate ultrasonic probe positioning, improve the success rate of venous blood sampling and patient comfort. The present application is widely applicable to blood sampling and other diagnosis and treatment operations under medical image guidance, and has good market prospect and practical application value.

Systems and methods are provided for intermittently occluding a venous vascular system of a patient to mitigate cardiac burden while increasing cardiac output and improving perfusion of the patient's heart. The system may include first and second balloon catheters selectively actuatable to intermittently occlude first and second veins to increase venous vascular resistance, respectively, of lower and upper limbs of the patient, thereby selectively reducing arterial blood flow to the lower and upper limbs, at the same time, the arterial vascular resistance of the heart and central organs of the patient is maintained and perfusion to the heart and central organs of the patient is increased.

The utility model relates to the technical field of medical care, and discloses a peripheral venous indwelling needle sterile application, which comprises an easy-to-tear layer, a peripheral venous indwelling needle sterile application layer and a peripheral venous indwelling needle sterile application layer, the fixing paste is pasted on the surface of one side of the easy-to-tear layer; the connecting layer is arranged on the surface of the side, away from the easy-to-tear layer, of the fixing patch, and the connecting layer and the fixing patch are integrally formed; the non-woven fabric layer is arranged on the surface of one side, far away from the fixing patch, of the connecting layer; the first fixing assembly is arranged on the non-woven fabric layer and used for fixing the remaining needle extension tube in a crossed mode; and the second fixing assembly is arranged on the first fixing assembly and is used for sticking the remaining needle extension tube. According to the peripheral vein indwelling needle sterile application, the technical effects that better indwelling needle management and patient nursing are provided, the discomfort, skin injury and infection risks are reduced, and the comfort and safety of a patient are improved are achieved.

The invention discloses a PICC (Peripherally Inserted Central Catheter) ultrasonic puncture positioning system, and belongs to the technical field of medical instruments. The invention discloses a PICC (Peripherally Inserted Central Catheter) ultrasonic puncture positioning system which comprises a data collection module, an identification model and a positioning module, the PICC positioning method solves the problem that the accuracy and practicability of the prior art are affected by factors such as ambient light and spatial layout, can extract more accurate sound wave features by using the Mel-frequency cepstrum coefficient to perform PICC positioning, effectively identifies and positions the sound wave signals of the PICC, improves the positioning precision, and improves the positioning accuracy. According to the PICC positioning device, interference of background noise on PICC positioning can be effectively reduced, positioning accuracy is improved, it can be ensured that medicine is smoothly conveyed, the treatment effect of the medicine is improved, damage to surrounding tissue is avoided, complications such as phlebitis and infection are reduced, and peripheral veins of a patient are protected against corrosion of chemotherapy medicine.