12 results about "Peripheral veins" patented technology

The invention relates to the field of molecular biology, in particular to a composition and a kit for detecting COX20 gene polymorphism and application of the composition and the kit. The SNP site of the COX20 gene of genome DNA in a human peripheral vein whole blood sample is determined by an ARMS-PCR fluorescent probe line method, and the genotype is tested and judged by two parallel tubes. Compared with a first-generation and second-generation sequencing method and other methods, the method has the advantages of simplicity in operation, low cost, short detection time and the like.

This invention is directed to compositions comprising bisantrene, particularly formulations of bisantrene dihydrochloride, wherein the formulations are suitable for intravenous administration into peripheral veins as well as methods for their use and methods for preparation of such compositions. The compositions according to the present invention eliminate the need to administer bisantrene by central venous catheter administration. The compositions can be used to treat malignancies and other conditions, and may be used for cardioprotection in patients undergoing chemotherapy with anthracycline-based anti-neoplastic agents. The inclusion of α-hydroxy acids in compositions according to the present invention improves the stability of such compositions and prevents precipitation of the bisantrene.

The utility model relates to a peripheral venous pressure monitoring device which comprises a hose (1) and an infusion nipple (2) arranged at the bottom end of the hose (1) and used for being connected with an indwelling needle, a closed normal saline storage portion (3) is arranged in the hose (1), and scales (4) are arranged on the side wall, located below the normal saline storage portion (3), of the hose (1). And the hose (1) is provided with a telescopic turning part (10) below the scales (4). Compared with the prior art, the peripheral venous pressure monitoring device provided by the utility model is convenient for medical staff to operate, and is convenient to carry and operate. When the disposable puncture needle is used, puncture operation is not needed, and pain of a patient is relieved. The pre-sealed normal saline also reduces the possibility of contamination during operation. And the bent part of the hose can be effectively prevented from being blocked, and data are more reliable and easy to obtain.

The invention discloses a perigastric vein segmentation and varicosity quantification method. The method comprises the following steps: S1, constructing a segmentation network of an anatomical prior path and a vein segmentation path to perform vein tissue segmentation; s2, extracting a vein contour based on a vein tissue segmentation result, calculating a maximum inscribed circle diameter of a vein through a scale adaptive fitting strategy, and realizing accurate conversion and correction of a physical size in combination with a pixel pitch in a medical image Dicom format; and S3, deploying a multi-condition constraint module at the tail end of the segmentation network, integrating vein morphological feature analysis, vein contrast enhancement processing and clinical anatomical standard verification, screening vein segments conforming to varicose vein features through a multi-dimensional scoring function, and optimizing a vein segmentation result. An intelligent and automatic solution is provided for the detection of the perigastric varicose veins, the technical development in the field of medical image analysis is promoted, and the application of AI in clinical diagnosis is further promoted.

The invention discloses a tumor metastasis risk assessment method and system based on circulating tumor DNA (ctDNA) spatial heterogeneity. The core of the method is as follows: blood samples of at least two different anatomical sites (such as peripheral veins and tumor drainage veins) of the same subject are obtained at the same time, and ctDNA in the samples is subjected to sequencing analysis; calculating characteristic data (such as a relative abundance ratio) representing ctDNA spatial distribution based on the mutation abundance difference between different parts; and finally, inputting the feature data into a pre-trained metastasis risk assessment model, and outputting a quantitative tumor metastasis risk score. According to the method, the limitation of traditional single-point liquid biopsy is broken through, the detection sensitivity of tiny metastases can be remarkably improved by utilizing the spatial distribution information of the ctDNA, potential metastasis positioning information is provided, and powerful technical support is provided for accurate diagnosis and treatment decision of tumor patients.

The invention relates to the technical field of medical auxiliary instruments, in particular to an auxiliary positioning device for peripheral vein puncture, which comprises a linear motor, a positioning frame and a controller, the positioning frame is fixedly arranged on a rotor of the linear motor, the positioning frame is used for assisting vein positioning puncture, the controller is arranged on one side of a shell of the linear motor, and the controller is arranged on the other side of the shell of the linear motor. The controller is externally connected with display equipment; the positioning frame comprises a sliding block, an arc-shaped frame and an arc-shaped plate, the sliding block is fixedly connected to a rotor of the linear motor, the arc-shaped frame is rotationally connected to the sliding block, and the arc-shaped plate is fixedly arranged on the arc-shaped frame. The positioning frame is driven by the linear motor to move horizontally, the mounting block is driven by the servo motor to slide back and forth along the arc-shaped frame, the ultrasonic probe can be automatically attached to the limb curved surface for systematic scanning, and full-level and multi-dimensional vein development from subcutaneous superficial layer to deep layer blood vessels is achieved in cooperation with the ultrasonic probe and the near-infrared optical module.

The utility model provides a peripheral vein catheterization limb fixator which comprises a supporting base, a first bevel gear, a pedal wheel, a second bevel gear, a lead screw, a connecting assembly and a bearing pad, and a containing space is formed in the supporting base; the first bevel gear is rotatably arranged in the accommodating space, and a threaded hole is formed in the middle of the first bevel gear; the pedal wheel is rotatably arranged on the supporting base in a penetrating manner and extends into the accommodating space; the second bevel gear is arranged in the accommodating space and connected with the pedal wheel, and the second bevel gear is meshed with the first bevel gear; the lead screw is arranged on the supporting base in a penetrating mode in the vertical direction, and the lead screw is arranged in the threaded hole in a penetrating mode and matched with the threaded hole in a threaded mode. The connecting assembly is connected with the screw rod; the bearing pad is arranged on the connecting assembly in the mode that the angle can be rotationally adjusted, a U-shaped groove used for bearing the wrist of the patient is formed in the bearing pad, and a bandage is arranged in the U-shaped groove. The device can replace an assistant, and can assist an operator to independently disinfect the upper arm of a patient and fix the punctured limb.

The invention relates to the technical field of venous indwelling catheter puncture navigation, and discloses a central venous indwelling catheter puncture auxiliary system through peripheral vein puncture. According to the system, an ultrasonic image and a dissection description text are acquired through a data acquisition and verification module; a three-dimensional blood vessel modeling module is used for carrying out spatial registration on the two blood vessels, and a three-dimensional blood vessel model containing semantic information is constructed; the anatomical variation analysis module is compared with a standard map, a variation region is automatically marked, and the puncture feasibility is evaluated; the puncture path planning module generates a target path in the feasible blood vessel model in combination with the instrument parameters, and decomposes the target path into executable steps associated with real-time ultrasonic features and specific operation instructions; and finally, the path conflict detection and navigation control module carries out calibration and sends an instruction to control the puncture auxiliary device to align. According to the method, a closed loop from objective evaluation of multi-source information fusion to programmed step navigation is realized, and the dependence on personal experience and spatial imagination of an operator is reduced.

The invention discloses a targeted retina drug-loaded extracellular vesicle as well as a preparation method and application thereof. The targeted retina drug-loaded extracellular vesicle comprises a lactobacillus-derived extracellular vesicle and a retina ischemia-reperfusion injury related disease treatment drug loaded in the extracellular vesicle, the medicine for treating the diseases related to the retinal ischemia reperfusion injury is indolepropionic acid; the loading capacity of the targeted retina drug-loading extracellular vesicle to indolepropionic acid is (6-8) * 10 <-8 > microgram / particle. The drug-loaded extracellular vesicle has the advantages of high drug loading rate, good biocompatibility, good gastrointestinal tract stability, high bioavailability and good safety. Besides, the extracellular vesicles loaded with indolepropionic acid can carry related marker proteins of retinal neurons through a membrane fusion technology, and can reach an eye retina area more efficiently through peripheral vein administration.

The invention relates to a bending-adjustable guide cannula for pulmonary artery interventional therapy. The bending-adjustable guide cannula comprises an outer sheath and an inner tube, the sheath is long enough to penetrate through the heart from the peripheral vein to be communicated to the pulmonary artery; the far end of the outer sheath is arranged to be a first bending part B with the inherent bending angle ranging from 80 degrees to 100 degrees. The inner tube is slidably arranged in the outer sheath in a penetrating mode, and the far end of the inner tube is provided with an inner tube bending adjusting section capable of being controlled to deflect through a pull wire; and the bending part is a second bending part A. By adjusting the handheld part, the axial distance between the two bending points of the fixed bend B and the adjustable bend A can be dynamically changed, in combination with the 360-degree rotating capacity of the inner tube and fine control over the angle of the bend adjusting section through the rotary knob, an operator can construct various composite bends in real time in the operation, pulmonary artery branch openings originating from different angles are accurately anchored, and the operation efficiency is improved. And a strong active supporting force is provided.

The invention belongs to the field of biological medicine, and particularly relates to a targeted medicine for treating prostatic cancer and application thereof. The drug is an Apt-C-C-S-PEG-CHO anchored 293T exosome loaded with siRNA-JAG1 and siRNA-NOTCH3, the drug with an optimized molar ratio can target prostate cancer cells through peripheral veins, and the malignant progression of the prostate cancer can be more effectively inhibited.

The utility model provides a kind of for peripheral vein blood sampling ultrasonic probe positioning support, including support, crossbeam, regulator. Support is made of two symmetrical supports, and support includes bottom bar and vertical rod, and adjusting vertical groove is provided on vertical rod, and crossbeam is placed between two vertical rods, and ultrasonic probe slot is equipped in the middle of crossbeam, and positioning pipe is fixed in end part, and positioning pipe is movably inserted in adjusting vertical groove. Regulator is configured at the both ends of crossbeam, and the adjustment of the position of crossbeam is realized by the pushing of pressing rod, and the accurate positioning of ultrasonic probe is ensured. By anti-skid gasket, silica gel soft pad and cross insertion rod structure, it is ensured that support is stable and convenient to store and transport. It can be fine-tuned according to the arm shape of different patients, provide accurate ultrasonic probe positioning, improve the success rate of venous blood sampling and patient comfort. The present application is widely applicable to blood sampling and other diagnosis and treatment operations under medical image guidance, and has good market prospect and practical application value.