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Anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and preparation method thereof

A vascular embolizing agent and deproteinization technology are applied to an anti-tumor vascular embolic agent containing aspartame deproteoglycan and its preparation, in the field of anti-tumor vascular embolic agents, and can solve the problems of impurities, low purity, and difficult to inject dosage forms. , to achieve the effect of improving immune function, reducing infection and improving liver function

Inactive Publication Date: 2012-07-18
SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The asparagus gum preparation of the prior art is made from asparagus crude polysaccharide obtained by decocting asparagus pieces through water decoction, sieving, concentrating, and ethanol precipitation, and adding iodine-containing solution, which still has certain impurities and is not pure enough. High defects, difficult to formulate an injectable dosage form for intravascular use

Method used

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  • Anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and preparation method thereof
  • Anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and preparation method thereof
  • Anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and preparation method thereof

Examples

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Effect test

Embodiment 1

[0048] Example 1 Preparation of anti-tumor vascular embolism agent (refined asparagus gum preparation) containing aspartate polysaccharide

[0049] (1) Extract asparagus crude polysaccharide

[0050] Take some asparagus decoction pieces (commercially available), soak them in distilled water, and crush them with a beater; soak them in cold water for 48 hours and filter them through gauze; repeat the extraction of the residue once with distilled water, combine the two extracts, and concentrate under reduced pressure; 75% ethanol precipitation Afterwards, centrifuge to remove the supernatant; successively wash the precipitate with 95% ethanol, absolute ethanol and ether; vacuum dry to obtain crude aspartame polysaccharide;

[0051] (2) Asparagus crude polysaccharide deproteinization

[0052] Aspartame crude polysaccharide was dissolved in distilled water, ultrasonically oscillated for 30 minutes, and water-insoluble substances were removed by centrifugation; streptavidin...

Embodiment 2

[0058] According to the preparation method of Example 1, get 5 grams of asparagus deproteinized polysaccharide fine powder, add iodine-containing solution earlier——non-ionic contrast agent iodidol injection (trade name: Sandaixian, English name: Iobitridol Injection, each 300 mg of iodine per milliliter, manufacturer: Guerbet) 30 milliliters, stand for 24 to 48 hours, fully swell the asparagus deproteopolysaccharide powder, then add iodine injection to 100 milliliters, mix well, dispense, 100 0 C steam sterilization for 1 hour to obtain the finished anti-tumor vascular embolism agent (refined asparagum preparation).

Embodiment 3

[0060] According to the preparation method of Example 1, get 15 grams of Asparagus deproteinized polysaccharide fine powder, add iodine-containing solution earlier—non-ionic contrast agent iodiridine injection (trade name: Sandaixian, English name: Iobitridol Injection, each 300 mg of iodine per milliliter, manufacturer: Guerbet) 60 milliliters, let it stand for 24 to 48 hours, after the fine powder of asparagus deproteopolysaccharide is fully swollen, then add iodine injection to 100 milliliters, mix well, and pack, 100 0 C steam sterilization for 1 hour to obtain the finished anti-tumor vascular embolism agent (refined asparagum preparation).

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to an anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and a preparation method thereof. According to the invention, the asparagus deproteinized polysaccharide is obtained from asparagus, i.e., a Chinese medicinal crop, through preparation processes such as extraction, deproteinization, purification and drying; and the asparagus deproteinized polysaccharide is added into iodine-containing solution to be prepared into a refined asparagus colloidal preparation of which every 100 ml contains 2.0-50.0 g of asparagus deproteinized polysaccharide. Experiments prove that the embolism agent has low toxicity, high compatibility with a water-soluble anti-tumor medicament and a medicament slow release effect; after the embolism agent is injected into hepatic artery, obstruction of local blood vessel can be caused to result in necrosis of tumor tissues; and the embolism agent also has a direct tumor suppression pharmaceutical effect and functions of straightening the body resistance and improving immunity and is an ending anti-tumor embolism agent with a good effect. According to the preparation method provided by the invention, the active ingredients in the medicinal crop can be efficiently reserved, the preparation of a Chinese medicinal preparation is simplified, the environment is protected, and the operation of batch production is facilitated.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to an anti-tumor blood vessel embolism agent, in particular to an anti-tumor blood vessel embolism agent containing aspartate deproteinized polysaccharide and a preparation method thereof. Background technique [0002] Transarterial chemoembolization has been recognized as the most effective conservative therapy for malignant tumors, especially for primary or metastatic liver cancer. However, the adverse effects of chemoembolic agents have become a key factor affecting the quality of life and survival of patients after treatment. So far, various forms of chemoembolization are aimed at the local treatment of tumors. It has achieved certain local curative effect, but at the same time, it has damaged liver function and immune status of the body. For example, the physical and chemical effects of iodized oil on target organs (such as liver) damage. In order to solve the physic...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/08A61P35/00
Inventor 张闽光陈刚刘力相建峰邢东炜耿坚黄学菁
Owner SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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