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Composition for treating cardiovascular diseases

A composition and cardiovascular technology, applied in cardiovascular system diseases, metabolic diseases, drug combinations, etc., can solve the problems of insignificant effects, unsatisfactory results, insignificant reductions in blood pressure and blood sugar, etc. High blood pressure and prevention of angina pectoris

Active Publication Date: 2013-08-07
王景胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After the 1995 patented product and No. 1 oral liquid patented in 1998 were launched, many consumers with a history of cardiovascular and cerebrovascular diseases reported that they were taking garlic health care solution and No. 1 Chinese herbal medicine allicin health care solution, both of which have similar properties , the effect of taking it is similar. After taking it for a month or two, I feel that "eating, sleeping, and mental state are much better", the reduction of hyperlipidemia is more obvious, and the reduction of blood pressure and blood sugar is not significant. In particular, although No. 1 traditional Chinese medicine allicin health care solution contains many drugs for lowering blood fat and blood pressure, the effect after combination is not significant. It may be that the effects of each drug cancel each other out, resulting in an unsatisfactory final result.
[0006] There are no reports on the combined use of nine ingredients including garlic, ginger, onion, Panax notoginseng, Polygonum multiflorum, Salvia miltiorrhiza, Pueraria lobata, safflower, and Chuanxiong

Method used

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  • Composition for treating cardiovascular diseases
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  • Composition for treating cardiovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0036] Examples 1-5: Compositions for the treatment of cardiovascular diseases

[0037] 1. Composition: See Table 1

[0038] Table 1: Composition of Examples 1-5

[0039]

[0040] 2, the preparation method of embodiment 1:

[0041] 1) Preparation of garlic liquid, ginger liquid and green onion liquid: Peel garlic, ginger and green onion respectively, weigh 5kg of garlic, 12kg of ginger and 5kg of green onion, wash them respectively, smash them into garlic paste, ginger paste, and green onion paste, Then respectively add 25kg, 60kg, 20kg edible ethanol (concentration 30%), seal and extract after 20 days, take out and filter, remove slag and obtain garlic liquid, ginger liquid, green onion liquid.

[0042] 2) Soaking solution of six traditional Chinese medicines: according to the proportioning of Example 1 in Table 1, take Radix Notoginseng, Radix Polygoni Multiflori, Salvia Miltiorrhiza, Radix Puerariae Radix, Safflower, Rhizoma Chuanxiong, add up to 174kg, add 350kg of ed...

experiment example 1

[0061] Experimental Example 1: Toxicity Test

[0062] 1. Acute toxicity test

[0063] 1. Experimental animals: first-class SD rats and NIH mice, purchased from the Experimental Animal Center of Sichuan Antibiotic Industry Research Institute.

[0064] 2. Test method: the acute toxicity tests of rats and mice are all according to Horn's method (Horn's method), and four dosage groups of the composition are established, which are respectively: 2150, 4640, 10000 and 21500mg / kg bw (the drug Be embodiment 2), every group of 10 animals (female, male half and half), all according to one-time oral gavage of 2% volume, observe its poisoning symptom, sign and death situation after gavage, observe continuously for two weeks, according to The acute toxicity was judged by the number of dead animals.

[0065] 3. Test results: see Table 1

[0066] Table 1: Acute Toxicity Test Results

[0067]

[0068] General observation: After a few minutes of intragastric administration of the test su...

experiment example 2

[0144] Experimental Example 2: Drug Efficacy Test

[0145] 1. Case collection: From October 2008 to August 2011, 360 hypertensive patients (170 males, 190 females, average age 55 years old, disease duration 0.5-20 years), 225 diabetic patients (115 males , 110 females, the case selection was in line with the diagnostic criteria for type 2 diabetes established in 1999, with an average age of 49 years, and the course of disease was 0.5-18 years) and 315 hyperlipidemia patients (154 males, 161 females, average age 54 years, The course of disease is 0.5-19 years).

[0146] 2. Medication method:

[0147] Hypertension, diabetes, and hyperlipidemia are each divided into 9 groups, respectively: placebo group, 1998 patent group (giving No. 1 drug 3ml / person), experiment 1 high-dose group (embodiment 3 drug, 1.5ml / person) , middle dosage group (embodiment 3 medicine, 2ml / person), low dosage group (embodiment 3 medicine, 3ml / person), experiment 1 group (embodiment 1 medicine, 2ml / perso...

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Abstract

The invention relates to a composition for treating cardiovascular diseases. The composition is prepared from the following components in parts by weight: 1-20 parts of garlic, 1-15 parts of ginger, 1-10 parts of green onion, 30-70 parts of pseudo-ginseng root, 10-40 parts of tuber fleeceflower root, 10-40 parts of red-rooted salvia root, 10-40 parts of kudzuvine root, 4-20 parts of safflower and4-20 parts of szechuan lovage rhizome. The composition provided by the invention has remarkable treatment effects on hyperlipemia, hyperglycemia and hypertension.

Description

technical field [0001] The invention relates to the field of health care products, in particular to a composition for treating cardiovascular diseases. Background technique [0002] The main ingredients of garlic (Allium sativun L) contain 0.2% volatile oil, and the oil contains allicin (commonly known as allicin (Allica)), a variety of sulfide compounds composed of allyl, propyl and methyl groups, citral, linaleol Alcohol, α, β-phellandrene, propionaldehyde, valeraldehyde, alliin; other ingredients include protein 4.4g, fat 0.2mg, carbohydrate 23g, crude fiber 0.7g, calcium 5mg, phosphorus 44mg, iron 0.4mg, sulfur Amine 0.24mg, riboflavin 0.03mg, nicotinic acid 0.9mg, ascorbic acid 3mg. Its pharmacological effects: In terms of cardiovascular, it is recorded on pages 110-111 of the first volume of the "Dictionary of Traditional Chinese Medicine" that garlic new gallon preparation has very little toxicity, can slow down heart rate, increase cardiac contractility, dilate peri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P3/06A61P3/10A61P9/12
Inventor 王景胜
Owner 王景胜
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