Preparation method of magnetic nanometer molecular imprinting composite material related to estrogen

A magnetic molecular imprinting and magnetic nanotechnology, which is applied in the field of preparation of amino-functional nano-ferric oxide magnetic molecular imprinting composite materials, can solve the problems of limited active sites, weak adsorption, cumbersome operation, etc., and achieve a functional group ratio. control, shorter reaction cycle, and simple preparation process

Inactive Publication Date: 2012-07-18
NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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Problems solved by technology

However, due to the use of functional monomers with low nitrogen content in the reaction, such as: 2-vinyl-pyridine, etc., the active sites (-N<) contained in this functional group are limited, a

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  • Preparation method of magnetic nanometer molecular imprinting composite material related to estrogen
  • Preparation method of magnetic nanometer molecular imprinting composite material related to estrogen
  • Preparation method of magnetic nanometer molecular imprinting composite material related to estrogen

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[0022] The preparation method of the magnetic nano molecular imprinting composite material of estrogen of the present invention includes the following steps:

[0023] 1. Preparation of monodisperse ferroferric oxide / polymer composite microspheres with high magnetic content: Nano ferroferric oxide particles are prepared by chemical co-precipitation method, and the surface is modified with oleic acid, and then prepared by suspension polymerization method. Monodisperse magnetic content of ferroferric oxide / polymer composite microspheres; specifically including the following sub-steps:

[0024] 1.1. Preparation of nano ferroferric oxide particles: dissolve ferric salt and ferric salt in water, the concentration of ferric salt is 0.1-0.4mol / L, and the concentration of ferric salt is 0.2-0.8mol / L; After ultrasonic dispersion for 1-10 minutes, at 60-90℃, add excess ammonia water to the pH of the solution to 10.0-12.0, stirring speed 300-600 rpm, constant temperature and constant speed me...

Example Embodiment

[0035] Example 1

[0036] (1) Weigh 5.56g FeSO respectively 4 ?7H 2 O and 10.58g FeCl 3 ?6H 2 O, dissolved in 200.0mL ultrapure water, ultrasonically dispersed for 5.0 minutes, heated to 60°C, stirred at 300 rpm, added excess ammonia to pH -11.0, reacted at constant temperature and speed for 1.0 hour, magnetic separation, successively Washing with ultrapure water and ethanol for several times until the pH is 6-8, and vacuum drying at 60° C. for 12 hours to prepare nano ferroferric oxide particles.

[0037] (2) Weigh 2.0 g of the nano ferroferric oxide particles prepared in step (1), and add them to 200.0 mL of ethanol solution, ultrasonically disperse for 5.0 minutes, and stir the reaction at a constant temperature of 60°C at a stirring speed of 300 rpm Add 20.0mL oleic acid dropwise at a constant speed within 10 minutes, react for 1.0 hour, magnetically separate, wash several times with ethanol to a pH of 6-8, and dry under vacuum at 60°C for 12 hours to prepare surface oleic acid...

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Abstract

The invention discloses a preparation method of a magnetic nanometer molecular imprinting composite material related to estrogen, comprising the following steps: dissolving bivalent iron salt and trivalent iron salt into water, performing ultrasonic dispersion, heating and regulating the system till being alkali, stirring the system, performing magnetic separation, washing the system till that pH is 6-8, and drying the system; adding ethanol solution, performing heating, stirring and dropping oleic acid, performing magnetic separation, washing the system till that pH is 7.0, and drying the system; adding a dispersant, a polymerization monomer, a functional monomer and a cross linker, and performing ultrasonic dispersion; adding an initiator, performing heating, stirring and magnetic separation, washing the system till that pH is 6-8, and drying the system; adding a composite reaction liquid of a template molecule and amino functional reagent, performing heating, stirring and magnetic separation, washing the system till that pH is 6-8, and drying the system to obtain a target product. The preparation method has the advantages of simple preparation process, controllable magnetic content, controllable functional group proportion and so on, and can arrive at a high enrichment factor when being applied in residual trace phenol environmental estrogens in enrichment drinking water.

Description

technical field [0001] The invention relates to a preparation method of an amino-functional nano-ferric iron tetroxide magnetic molecular imprinting composite material with a core-shell structure, in particular to a preparation method of an aminated nano-ferric iron tetroxide magnetic molecular imprinting composite material. Background technique [0002] With the rapid development of modern industry and agriculture, the pollution and harm of phenolic environmental estrogens have become the focus of attention of all countries in the world. The latest research shows that 0.1μg / L or even lower levels of phenolic environmental estrogen can cause biological effects in experimental animals and interfere with the secretion of endogenous hormones in organisms. an important direction of research. Among them, some phenolic environmental estrogens are used as additives for the preparation of epoxy resins and polycarbonate plastics. When they enter the organism, they can cause endocrin...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F220/14C08F220/32C08F8/32C08J9/26B01J20/26B01J20/28B01J20/30C02F1/28C02F1/58
Inventor 赵永纲金米聪陈晓红
Owner NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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