Method for preparing three-dimensional electrostatic-spinning nonwoven support material and device thereof

Abstract

The invention relates to a method for preparing a three-dimensional electrostatic-spinning nonwoven support material and a device thereof. The method comprises the following steps: (1) dissolving a spinning polymer in a mixed solvent of acetone / dimethyl formamide, and obtaining a spinning solution after mixing; (2) pouring the spinning solution into a solution tank, and grounding a receiving roller to apply high-voltage static electricity to the spinning solution for electrostatic spinning; after electrostatic spinning lasting for 5-20 minutes, taking down a fluffy fiber net from the receiving roller, thus obtaining a three-dimensional nonwoven fiber support material; (3) and carrying out vacuum drying on the three-dimensional nonwoven fiber support material for hours, and removing the residual solvent. The device comprises a motor, the solution tank, a spinning turntable, the receiving roller, an electrostatic generator and an infrared heater. The method of the invention is simple and convenient in operation, low in cost and high in yield. The obtained support material with a three-dimensional structure has advantages of fluffy structure, large hole diameter and good biocompatibility, and is beneficial to cells to inwardly grow.

Description

technical field

[0001] The invention belongs to the field of preparation of an electrospinning support material and its device, and in particular relates to a preparation method and a device of a three-dimensional electrospinning non-woven support material. Background technique

[0002] Electrospinning technology, due to its easy operation and wide range of spinnable materials, has been developed rapidly in the past two decades and is becoming one of the most commonly used technologies in the preparation of ultrafine fibers. The diameter of electrospun fibers is mostly nano or submicron, with extremely high specific surface area and porosity, and has certain application potential in tissue engineering, smoke filtration, battery diaphragm preparation and other fields.

[0003] In tissue engineering, electrospun fiber scaffolds can biomime human extracellular matrix in terms of structure and function, which can accelerate cell growth and promote tissue healing. However, tradi...

Examples

Embodiment 1

[0031] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0032] (1) Cellulose acetate butyrate is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.2 g / ml after stirring;

[0033] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 50 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 20 rpm , the distance between the turntable and the roller is 18 cm, and the peripheral temperature of the receiving roller is controlled at 120 d...

Embodiment 2

[0038] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0039] (1) Cellulose acetate butyrate is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.4 g / ml after stirring;

[0040] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 50 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 40 rpm , the distance between the turntable and the roller is 25 cm, and the peripheral temperature of the receiving roller is controlled at 80 de...

Embodiment 3

[0045] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0046] (1) polystyrene is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.0 g / ml after stirring;

[0047] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 60 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 60 rpm , the distance between the turntable and the roller is 18 cm, and the peripheral temperature of the receiving roller is controlled at 110 degrees Celsius ...

technical field

[0001] The invention belongs to the field of preparation of an electrospinning support material and its device, and in particular relates to a preparation method and a device of a three-dimensional electrospinning non-woven support material. Background technique

[0002] Electrospinning technology, due to its easy operation and wide range of spinnable materials, has been developed rapidly in the past two decades and is becoming one of the most commonly used technologies in the preparation of ultrafine fibers. The diameter of electrospun fibers is mostly nano or submicron, with extremely high specific surface area and porosity, and has certain application potential in tissue engineering, smoke filtration, battery diaphragm preparation and other fields.

[0003] In tissue engineering, electrospun fiber scaffolds can biomime human extracellular matrix in terms of structure and function, which can accelerate cell growth and promote tissue healing. However, tradi...

Examples

Embodiment 1

[0031] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0032] (1) Cellulose acetate butyrate is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.2 g / ml after stirring;

[0033] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 50 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 20 rpm , the distance between the turntable and the roller is 18 cm, and the peripheral temperature of the receiving roller is controlled at 120 d...

Embodiment 2

[0038] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0039] (1) Cellulose acetate butyrate is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.4 g / ml after stirring;

[0040] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 50 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 40 rpm , the distance between the turntable and the roller is 25 cm, and the peripheral temperature of the receiving roller is controlled at 80 de...

Embodiment 3

[0045] According to the aforementioned preparation of the three-dimensional electrospinning nonwoven support material in the present invention, including the preparation of the spinning solution, the setting of the electrospinning parameters, the steps of fiber collection and vacuum drying, the following process conditions are adopted:

[0046] (1) polystyrene is dissolved in the mixed solvent of acetone / dimethylformamide (volume ratio 2 / 1), obtains the spinning solution that concentration is 1.0 g / ml after stirring;

[0047] (2) Pour the spinning solution into the solution tank, ground the receiving roller, apply 60 kilovolts of high-voltage static electricity to the spinning solution to carry out electrospinning, the rotating speed of the spinning turntable is 50 rpm, and the rotating speed of the receiving roller is 60 rpm , the distance between the turntable and the roller is 18 cm, and the peripheral temperature of the receiving roller is controlled at 110 degrees Celsius ...

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