Compound preparation of glucosamine chondroitin and production method of compound preparation

A technology of compound preparation and production method, which is applied in medical preparations containing active ingredients, food preparation, pill delivery, etc., can solve problems such as softening of cartilage matrix, increase of cartilage surface cavities, and obstruction of GS synthesis, and achieve good compressibility Sex and stability, improve product quality, and reduce production costs

Inactive Publication Date: 2012-07-25
DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]Glucosamine is a natural amino monosaccharide, which is the most important monosaccharide constituting polyglucosamine (GS) and proteoglycan in the matrix of articular cartilage. Normal people GS can be synthesized through the amination of glucose, but the

Method used

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  • Compound preparation of glucosamine chondroitin and production method of compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of compound preparation of glucosamine salts and chondroitin sulfate (5:4)

[0043] Glucosamine Hydrochloride 1500g

[0044] Chondroitin Sulfate 1200g

[0045] Microcrystalline Cellulose 120g

[0046] Sodium carboxymethyl starch 45g

[0047] Sodium Carboxymethyl Cellulose 1.5g

[0048] Tartaric acid 0.5g

[0049] Magnesium Stearate 15g

[0050] Appropriate amount of water

[0051] Coating Premix 40g

[0052] Prepare as follows:

[0053] 1. Mix the adhesive and stabilizer, use an appropriate amount of water to prepare an adhesive solution with a concentration of 0.1-5%, fully dissolve until clear and transparent, crush the raw materials, pass through a 60-120 mesh sieve, and mix glucosamine and an appropriate amount Chondroitin sulfate (accounting for 3 to 10%) is put into a wet granulator and stirred for 1 to 10 minutes, mixed evenly, uniformly and slowly added to the prepared binder solution, adding liquid while stirring to make granules,...

Embodiment 2

[0057] Example 2: Preparation of Compound Preparation of Glucosamine Salts and Chondroitin Sulfate (5:4)

[0058] Glucosamine Sulfate Potassium Salt 750g

[0059] Chondroitin Sulfate 600g

[0060] Collagen 150g

[0061] Microcrystalline Cellulose 120g

[0062] Sodium carboxymethyl starch 45g

[0063] Hydroxypropyl methylcellulose 0.5g

[0064] Sodium carboxymethylcellulose 0.5g

[0065] Tartaric acid 0.5g

[0066] Magnesium Stearate 15g

[0067] Appropriate amount of water

[0068] Coating Premix 40g

[0069] Prepare as follows:

[0070] 1. Mix the adhesive and stabilizer, use an appropriate amount of water to prepare an adhesive solution with a concentration of 0.1-5%, fully dissolve until clear and transparent, crush the raw materials, pass through a 60-120 mesh sieve, and mix glucosamine and an appropriate amount Put chondroitin sulfate (3-10%) into the wet granulator and stir for 1-10 minutes, mix well, evenly and slowly add the prepared binder solution, add liqu...

Embodiment 3

[0074] Example 3: Preparation of Compound Preparation of Glucosamine Salts and Chondroitin Sulfate (5:4)

[0075] Glucosamine Hydrochloride 500g

[0076] Chondroitin Sulfate 400g

[0077] Collagen 150g

[0078] Dimethylsulfone 150g

[0079] Microcrystalline Cellulose 120g

[0080] Sodium carboxymethyl starch 45g

[0081] Sodium carboxymethylcellulose 0.8g

[0082] Tartaric acid 0.5g

[0083] Magnesium Stearate 15g

[0084] Appropriate amount of water

[0085] Coating Premix 40g

[0086] Prepare as follows:

[0087] 1. Mix the adhesive and stabilizer, use an appropriate amount of water to prepare an adhesive solution with a concentration of 0.1-5%, fully dissolve until clear and transparent, crush the raw materials, pass through a 60-120 mesh sieve, and mix glucosamine and an appropriate amount Put chondroitin sulfate (3-10%) into the wet granulator and stir for 1-10 minutes, mix well, evenly and slowly add the prepared binder solution, add liquid while stirring to gr...

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PUM

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Abstract

The invention discloses a compound preparation of glucosamine chondroitin. The compound preparation comprises the following main components of: glucosamine salts and chondroitin sulfate as main active components, one or several of dimethyl sulfone and collagen as auxiliary components and an accessory. Mixed granules produced by the compound preparation disclosed by the invention have better compressibility and stability; the consumption of the accessory is reduced, so that the production cost is reduced; the quality of products is reduced; and the compound preparation is especially suitable for middle-aged groups suffering from rheumatic arthritis and groups whose moving joints are injured.

Description

technical field ： [0001] The invention relates to the field of health food, in particular to a compound preparation of aminochondroitin and a preparation method thereof. Background technique: [0002] Osteoarthritis is a common chronic arthritis, and people have been looking for and exploring drugs for the progression of the disease for many years. Rheumatoid arthritis, rheumatoid arthritis, etc. bring inconvenience and pain to patients (especially in the morning or when the weather changes). For a long time, people have used aspirin, non-steroidal analgesics, etc. to help patients relieve pain. These medicines are used for a long time, and some effects gradually decrease, and some produce side effects such as bloating and stomach pain. [0003] Arthritis is mainly the degeneration of articular cartilage and secondary hyperosteogeny. Because the mucous membrane at the joint joint is composed of sulfur-containing protein and glucosamine. Sulfur-containing proteins such ...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K31/737A61K31/7008A61K31/10A61K9/28A61P1/14A61P19/02A23L1/29A23L33/00
Inventor 张国栋王乔飞杨玉香边立峰夏旭东
Owner DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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