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Resveratrol nanostructured lipid carrier and preparation method thereof

A nanostructured lipid and resveratrol technology, applied in the field of carrier systems, can solve the problems of low bioavailability and poor drug stability of resveratrol, and achieve simple preparation methods, reduced drug leakage, and increased loading capacity Effect

Inactive Publication Date: 2012-08-01
夏强 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a water-soluble resveratrol nanostructured lipid carrier with high stability and good compatibility, which solves the problems of poor drug stability and low bioavailability of resveratrol in the prior art

Method used

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  • Resveratrol nanostructured lipid carrier and preparation method thereof
  • Resveratrol nanostructured lipid carrier and preparation method thereof
  • Resveratrol nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Resveratrol Nanostructured Lipid Carrier

[0036] Composition formula

[0037]

[0038] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0039] 1. Weigh 2.0 grams of Tween 60, 1.0 grams of GSC, and 50.9 grams of distilled water into a beaker, and heat in a water bath at 70°C.

[0040] 2. Weigh 3.6 g of acetylated monoglycerides, 2.1 g of triacetin, and 0.3 g of peach resin, and heat them in a water bath at 70° C.

[0041] 3. After the lipid in the beaker is completely melted, add 0.1 g of resveratrol and heat to dissolve for 30 minutes.

[0042] 4. Add the water phase to the above system, stir evenly, and shear. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 75°C;

[0043] 5. Inject the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 60MPa, and circulate the homogenization 4 times und...

Embodiment 2

[0045] Example 2 Preparation of Resveratrol Nanostructured Lipid Carrier

[0046] Composition formula

[0047]

[0048] Preparation steps:

[0049] 1. Weigh 2.0 grams of Tween 60, 1.0 grams of GSC, and 50.9 grams of distilled water into a beaker, and heat in a water bath at 70°C.

[0050] 2. Weigh 3.6 g of acetylated monoglyceride, 1.8 g of diethyl sebacate, and 0.6 g of peach resin, and heat in a water bath at 70° C.

[0051] 3. After the lipid in the beaker is completely melted, add 0.1 g of resveratrol and heat to dissolve for 30 minutes.

[0052] 4. Add the water phase to the above system, stir evenly, and shear. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 75°C;

[0053] 5. Put the uniformly stirred high-temperature emulsion system into the high-pressure homogenizer, adjust the homogenization pressure to 50MPa, and circulate the homogenization 4 times under this pressure;

[0054] 6. Cool to room temperature to obta...

Embodiment 3

[0055] Example 3 Preparation of Resveratrol Nanostructured Lipid Carrier

[0056] Composition formula

[0057]

[0058]

[0059] Preparation steps:

[0060] 1. Weigh 3.6 grams of Tween 60, 1.2 grams of GSC, and 49.1 grams of distilled water into a beaker, and heat in a water bath at 70°C.

[0061] 2. Weigh 3.6 g of acetylated monoglycerides, 2.1 g of triacetin, and 0.3 g of peach resin, and heat them in a water bath at 70° C.

[0062] 3. After the lipid in the beaker is completely melted, add 0.1 g of resveratrol and heat to dissolve for 30 minutes.

[0063] 4. Add the water phase to the above system, stir evenly, and shear. At the same time, turn on the high-pressure homogenizer and preheat it with distilled water at 75°C;

[0064] 5. Put the uniformly stirred high-temperature emulsion system into a high-pressure homogenizer, adjust the homogenization pressure to 70MPa, and circulate the homogenization for 5 times under this pressure;

[0065] 6. Cool to room temper...

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Abstract

The invention discloses a resveratrol nanostructured lipid carrier. The resveratrol nanostructured lipid carrier is loaded with active pharmaceutical ingredients of resveratrol and is characterized by comprising 0.1 to 1wt% of resveratrol, 2 to 20wt% of at least one emulsifier, 2 to 30wt% of a composite lipid material and the balance water, wherein the composite lipid material is a mixture of at least one solid lipid material and at least one liquid lipid material. The at least one solid lipid material and the at least one liquid lipid material are selected from glyceryl triacetate, acetylated monoglyceride, diethyl sebacate, diisopropyl adipate, diisopropyl sebacate, glycerol monolaurate, peach resin and an octadecyl alcohol. The resveratrol nanostructured lipid carrier has good stability and water-solubility. The preparation method of the resveratrol nanostructured lipid carrier is simple and controllable and has good repeatability. The resveratrol nanostructured lipid carrier can be utilized in preparation of resveratrol-containing cosmetics.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a nanoscale carrier and a preparation method thereof, in particular to a nanostructured lipid carrier with resveratrol as an active ingredient and a preparation method thereof. Background technique [0002] Resveratrol (Res for short), also known as stilbene triphenols, is a colorless needle crystal with molecular formula C 14 h 12 o 3 , the chemical name is 3,4,5-1,2-trihydroxy-stilbene (trans-3,4,5-trihydroxy-stilbene), it is liquid or solid powder, and the relative molecular mass is 228.25. There are two structural formulas of resveratrol, cis and trans, and each can combine with glucose to form cis and trans. Resveratrol has a melting point of 256-257°C, sublimates at 261°C, and is easily soluble in ether, methanol, ethanol, propanol, etc. It can produce fluorescence under the irradiation of 366nm ultraviolet light, and c...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/72A61K8/86A61K8/49A61K8/14A61K8/34A23L1/30A61Q19/00
Inventor 夏强赵吴君
Owner 夏强
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