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Targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier, and preparation method and application thereof

A technology of polyethyleneimine and carbon nanotubes, which is applied in the direction of pharmaceutical formulations, preparations for in vivo tests, medical preparations of non-active ingredients, etc., can solve the problem that carbon nanotubes are difficult to dissolve in water and organic solvents, and limit research It has good biocompatibility, easy access to raw materials, and convenient operation due to problems such as application and easy aggregation into bundles

Inactive Publication Date: 2012-08-08
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Carbon nanotubes are insoluble in water and organic solvents, and are easy to aggregate into bundles in solution, which can be said to greatly limit its research and application in many fields, especially in biomedicine.

Method used

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  • Targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier, and preparation method and application thereof
  • Targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier, and preparation method and application thereof
  • Targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier, and preparation method and application thereof

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Embodiment

[0043] 1) Weigh 1 to 2 g of carbon nanotubes (10 to 20 nm in diameter and 1 to 2 μm in length) in a 250 mL flask;

[0044] 2) Add 45mL of concentrated sulfuric acid and 15mL of concentrated nitric acid, and stir under reflux in an oil bath at 140°C for 24 hours. After the end, remove the reflux device and let it cool down to room temperature;

[0045] 3) After the natural sedimentation is complete, wash by centrifugation (12000, 12min), wash with a large amount of distilled water until neutral, and then put it in a vacuum oven at 50°C to dry to obtain MWCNT-COOH, which is stored in a desiccator for later use.

[0046] figure 1 It is (a) a transmission electron microscope (TEM) picture and (b) a scanning electron microscope (SEM) picture of acid-treated carbon nanotubes in this embodiment. Electron micrographs show that the average length of the acid-treated carbon nanotubes in the present invention is less than 300 nanometers.

[0047] 4) Weigh 30mg MWCNT-COOH in a 250mL beak...

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Abstract

The invention discloses a targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier for prostate cancer. A carbon nanotube with a diameter of 10-20nm and an average length of less than 300nm has carboxyl groups on surface thereof, and is modified by branched polyethylene imine; amino groups on polyethylene imine are utilized to further modify the carbon nanotube by connecting dansyl luminescent groups and human prostate stem cell antigen ( PSCA ) antibody. Method for preparing the material comprises steps of: refluxing the carbon nanotube in concentrated sulphuric acid and concentrated nitric acid to prepare the carbon nanotube with carboxyl groups on surface thereof; and then cladding branched polyethylene imine onto the surface of the carbon nanotube through amide bonds to enable the carbon nanotube with good water solubility and a large number of amino groups on surface thereof; and then attaching sulfonyl groups and PSCA antibody to the surface of the carbon nanotube through the amino groups. The drug delivery carrier prepared by the invention has good biocompatibility, little material toxicity, strong drug load capability, and good luminescent properties and targeting properties.

Description

technical field [0001] The invention relates to a prostate cancer targeting multifunctional carbon nanotube / polyethyleneimine drug delivery carrier and its preparation method and application, belonging to the technical field of nanocomposite materials and nanometer drug carriers. Background technique [0002] Carbon nanotube (Carbon nanotube, referred to as CNT) is a seamless hollow nano-scale coaxial cylinder rolled from sheet-structured graphite, and each layer is composed of carbon atoms through sp 2 The hexagonal plane formed by hybridization and the surrounding three carbon atoms is completely bonded to form a cylindrical surface, and the two ends are closed by pentagons or heptagons. Its diameter is at the nanometer level, but its length can reach the order of microns or even centimeters. Generally, the aspect ratio can be used to express the size of carbon nanotubes, and its value can reach 10. 3 magnitude or greater. Therefore, carbon nanotubes have the characteris...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/04A61K47/34A61K49/00
Inventor 吴惠霞王雪侍海丽杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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