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Preparation method of high-activity low-expansion biological microcrystalline glass

A glass-ceramic, low-expansion technology, used in medical science, coatings, prostheses, etc., can solve the problems of unsuitable titanium alloy surface active coating materials and less research on biological glass-ceramic coating materials. The effect of improving mechanical properties and improving mechanical properties

Inactive Publication Date: 2012-08-15
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the glass-ceramics prepared above are mainly used directly in the repair or replacement of hard tissues, and are not suitable as active coating materials on the surface of titanium alloys. At present, there are few studies on biological glass-ceramics coating materials on titanium alloy surfaces.

Method used

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  • Preparation method of high-activity low-expansion biological microcrystalline glass
  • Preparation method of high-activity low-expansion biological microcrystalline glass
  • Preparation method of high-activity low-expansion biological microcrystalline glass

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of 45S5 bioactive glass-ceramics (N1), the process is as follows:

[0038] Weigh orthoethyl silicate Si(OC) according to the ratio in Table 1-1 2 h 5 ) 4 , triethyl phosphate OP(OC 2 h 5 ) 3 , calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O, sodium nitrate NaNO 3 ; Under the catalysis of 25ml nitric acid solution (2mol / L), ethyl orthosilicate was pre-hydrolyzed for 30min under stirring in 208.77ml deionized water, then added triethyl phosphate for hydrolysis for 30min, then added calcium nitrate tetrahydrate and sodium nitrate And stir to fully dissolve to form a clear sol; place the clear sol in an airtight container at room temperature for 3 days, after it forms a gel, put it in a constant temperature water bath at 60°C for aging treatment for 3 days, and place the obtained semi-dry gel in Dried in a drying oven to obtain a dry gel;

[0039] The obtained xerogel is ball milled in a ball mill and sieved to 200 meshes to obtain glass ...

Embodiment 2

[0044] Embodiment 2: preparation adds K 2 O bioactive glass-ceramics (N2) with 6 mol% K 2 O replaces 6 mol% CaO in 45S5, the process is as follows:

[0045] Weigh orthoethyl silicate Si(OC 2 h 5 ) 4 , triethyl phosphate OP(OC 2 h 5 ) 3 , calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O, sodium nitrate NaNO 3 , potassium nitrate KNO 3 ; Under the catalysis of 25ml nitric acid solution (2mol / L), ethyl orthosilicate was pre-hydrolyzed for 30min under stirring in 208.77ml deionized water, then added triethyl phosphate for hydrolysis for 30min, then added calcium nitrate tetrahydrate and sodium nitrate , potassium nitrate and stir to dissolve fully to form a clear sol; place the clear sol in an airtight container at room temperature for 6 days, and after it forms a gel, put it in a constant temperature water bath at 60°C for aging treatment for 3 days, and the obtained semi-dry The gel is placed in a drying oven to dry to obtain a dry gel;

[0046] The obtained xerogel ...

Embodiment 3

[0051] Embodiment 3: preparation adds B 2 o 3 Bioactive glass-ceramic (N3) with 6 mol% B 2 o 3 To replace 6 mol% CaO in 45S5, the process is as follows:

[0052] Weigh orthoethyl silicate Si(OC 2 h 5 ) 4 , triethyl phosphate OP(OC 2 h 5 ) 3 , calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O, sodium nitrate NaNO 3 , boric acid H 3 BO 3 ; Under the catalysis of 25ml nitric acid solution (2mol / L), ethyl orthosilicate was pre-hydrolyzed for 30min under stirring in 208.77ml deionized water, then added triethyl phosphate for hydrolysis for 30min, then added calcium nitrate tetrahydrate and sodium nitrate , boric acid and stirred to fully dissolve to form a clear sol; the clear sol was placed in a closed container at room temperature for 3 days, and after it formed a gel, it was placed in a 60°C constant temperature water bath for aging treatment for 3 days, and the obtained semi-dry condensed The glue is placed in a drying oven to dry to obtain a dry gel;

[0053] The...

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Abstract

The invention relates to a preparation method of high-activity low-expansion biological microcrystalline glass. The preparation method comprises the steps of: pre-hydrolyzing tetraethyl orthosilicate in de-ionized water for 20 to 40 minutes under the catalysis of a proper amount of nitric acid solution, adding triethyl phosphate for hydrolysis for 20 to 40 minutes, adding calcium nitrate, sodium nitrate and dopants and then stirring for 1 to 2 hours so as to realize sufficient solution to form clear sol, putting the sol for being dried to obtain dried gel, then stabilizing the dried gel, and finally crystallizing the dried gel in two steps. The bioactive microcrystalline glass provided by the invention has a linear expansibility of about 10*10<-6> / DEG C in accordance with the measurement of a thermal dilatometer, which meets the demand on the linear expansibility of titanium alloy coating material; and the prepared bioactive microcrystalline glass has excellent bioactivity.

Description

technical field [0001] The invention relates to a preparation process of high-activity and low-expansion biological glass-ceramic and a microcrystalline phase. Background technique [0002] Due to its high specific strength, low elastic modulus, excellent corrosion resistance and biocompatibility, titanium alloy has become the first choice for artificial joints and orthopedic implant materials and has been applied in clinical practice. However, wear and stress corrosion are obvious under loading conditions, and toxic elements such as Al and V are easily precipitated. After implantation, the bonding strength with the surrounding bone tissue is low, and the interface bonding is unstable, which may easily cause implant loosening or fracture, resulting in implant failure. Therefore, the preparation of bioactive coatings on the surface of titanium alloys promotes the formation of chemical bonds with bone tissue, avoids friction with bones when loaded, reduces wear and corrosion, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C10/04A61L27/32A61L27/50
Inventor 王佃刚陈传忠户俊华
Owner SHANDONG UNIV
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