Modified chitosan drug carrying microsphere and method for preparing same

Abstract

The invention relates to the preparation of a modified chitosan drug carrying microsphere. Firstly, hymecromone is modified to obtain a hydrophobic group, the modified hymecromone is then used for modifying chitosan into an amphipathic chitosan which has a hydrophilic chain and a hydrophobic chain at the same time, an antibacterial agent is then added, and the chitosan drug carrying microsphere is produced by adopting a self-assembly method. The method has a simple preparation technology and moderate reaction conditions, and is lower in cost, and the prepared modified chitosan has amphipathy, the antibacterial agent is added, the drug carrying microsphere can be self assembled without adding a crosslinking agent, so the cytotoxicity is avoided. Moreover, the added antibacterial agent is the natural biological extract, so beneficial fungi and normal cells in the human body can be prevented from being damaged.

Description

technical field

[0001] The invention relates to modified chitosan drug-loaded microspheres and a preparation method thereof Background technique

[0002] Chitosan is an alkaline polysaccharide obtained by removing more than 55% of its N-acetyl group. It is the only naturally occurring hydrophilic cationic biodegradable polysaccharide with good biocompatibility. Its decomposition products Can be completely absorbed by the human body, therefore, chitosan is a good carrier for drug sustained release. The methods for preparing chitosan drug-loaded microspheres mainly include emulsification cross-linking method, ion gelation method, molecular self-assembly method and so on. Glutaraldehyde is often used as a crosslinking agent in the preparation of microspheres by emulsification crosslinking, and proteins or peptides will react with glutaraldehyde to make them resistant to genotoxicity. Therefore, the application of this method to protein and peptide drugs is very limited. . Th...