Novel levo-carnitine hydrogel patch and preparation method thereof
A technology of hydrogel patch and L-carnitine, applied in the field of medicine, can solve the problems of unsatisfactory skin penetration effect, high peeling strength, easy loss of viscosity, etc., so as to avoid peak-to-valley fluctuation and compatibility of blood drugs. Good, smooth absorption effect
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[0032] Example 1:
[0033] 1. Take 6.00 g of sodium polyacrylate, 1.00 g of kaolin, 0.57 g of aluminum glycerol, and 0.40 g of EDTA, and disperse in a mixture of 35.00 g of glycerol and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain a uniform dispersed phase I.
[0034] 2. Take 1.00g of sodium alginate, 5.00g of L-carnitine, and 1.50g of tartaric acid, and dissolve them in 60.00g of distilled water. The solution phase II was obtained by constant stirring at 90°C for 30 minutes.
[0035] 3. Mix the homogeneous dispersion phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. The drug-containing matrix was obtained by drying at 75°C for 15 minutes.
[0036] 4. Coat the drug-containing matrix evenly on the non-woven fabric of the backing layer, cover it with a protective layer, then mold it, and then cut it into the required sample size as needed.
Example Embodiment
[0037] Example 2:
[0038] 1. Take 6.00 g of sodium polyacrylate, 1.00 g of kaolin, 0.57 g of aluminum carboxylate, 0.40 g of EDTA, and 0.5 g of vitamin E, and disperse them in a mixture of 35.00 g of glycerol and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain uniform dispersion. Phase I.
[0039] 2. Dissolve 1.00g of sodium alginate, 5.00g of L-carnitine and 1.50g of tartaric acid in 60.00g of distilled water. The solution phase II was obtained by constant stirring at 90°C for 30 minutes.
[0040] 3. Mix the homogeneous dispersion phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. The drug-containing matrix was obtained by drying at 75°C for 15 minutes.
[0041] 4. Coat the drug-containing matrix evenly on the non-woven fabric of the backing layer, cover it with a protective layer, then mold it, and then cut it into the required sample size as needed.
Example Embodiment
[0042] Example 3:
[0043] 1. Take 6.00 g of sodium polyacrylate, 1.00 g of kaolin, 0.57 g of aluminum glycerol, and 0.40 g of EDTA, and disperse in a mixture of 35.00 g of glycerol and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain a uniform dispersed phase I.
[0044] 2. Dissolve 1.00 g of sodium alginate, 5.00 g of L-carnitine, 1.50 g of tartaric acid, and 0.5 g of menthol in 60.00 g of distilled water. The solution phase II was obtained by constant stirring at 90°C for 30 minutes.
[0045] 3. Mix the homogeneous dispersion phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. The drug-containing matrix was obtained by drying at 75°C for 15 minutes.
[0046] 4. Coat the drug-containing matrix evenly on the non-woven fabric of the backing layer, cover it with a protective layer, then mold it, and then cut it into the required sample size as needed.
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