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Novel levo-carnitine hydrogel patch and preparation method thereof

A technology of hydrogel patch and L-carnitine, applied in the field of medicine, can solve the problems of unsatisfactory skin penetration effect, high peeling strength, easy loss of viscosity, etc., so as to avoid peak-to-valley fluctuation and compatibility of blood drugs. Good, smooth absorption effect

Inactive Publication Date: 2012-10-03
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Combining the advantages of hydrogel, it makes up for the shortcomings of existing dosage forms: it is not suitable for L-carnitine administration, and it is easy to lose viscosity when it hardens over time.
Solved the problem of unsatisfactory transdermal effect
It also overcomes the shortcomings of traditional patches such as pressure-sensitive adhesives and rubber adhesives, such as slow drug release, loss of viscosity when exposed to water, and excessive peel strength.

Method used

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  • Novel levo-carnitine hydrogel patch and preparation method thereof
  • Novel levo-carnitine hydrogel patch and preparation method thereof
  • Novel levo-carnitine hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Take 6.00 g of sodium polyacrylate, 1.00 g of kaolin, 0.57 g of glyoxate, and 0.40 g of EDTA, and disperse them in a mixture of 35.00 g of glycerin and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain a uniform dispersed phase I.

[0034] 2. Take 1.00 g of sodium alginate, 5.00 g of L-carnitine, and 1.50 g of tartaric acid, and dissolve them in 60.00 g of distilled water. Stir at a constant speed at 90°C for 30 minutes to obtain a solution phase II.

[0035] 3. Mix the uniformly dispersed phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. Dry at 75° C. for 15 minutes to obtain a drug-containing matrix.

[0036] 4. Evenly coat the drug-containing matrix on the non-woven fabric of the backing layer, cover with a protective layer, mold it, and then cut it into the required sample size as needed.

Embodiment 2

[0038] 1. Take 6.00g of sodium polyacrylate, 1.00g of kaolin, 0.57g of aluminum glyoxate, 0.40g of EDTA, and 0.5g of vitamin E, and disperse them in a mixture of 35.00g of glycerin and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain a uniform dispersion Phase I.

[0039] 2. Dissolve 1.00g of sodium alginate, 5.00g of L-carnitine and 1.50g of tartaric acid in 60.00g of distilled water. Stir at a constant speed at 90°C for 30 minutes to obtain a solution phase II.

[0040] 3. Mix the uniformly dispersed phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. Dry at 75° C. for 15 minutes to obtain a drug-containing matrix.

[0041] 4. Evenly coat the drug-containing matrix on the non-woven fabric of the backing layer, cover with a protective layer, mold it, and then cut it into the required sample size as needed.

Embodiment 3

[0043] 1. Take 6.00 g of sodium polyacrylate, 1.00 g of kaolin, 0.57 g of glyoxate, and 0.40 g of EDTA, and disperse them in a mixture of 35.00 g of glycerin and propylene glycol, and stir at a constant speed for 30 minutes at room temperature to obtain a uniform dispersed phase I.

[0044] 2. Dissolve 1.00g of sodium alginate, 5.00g of L-carnitine, 1.50g of tartaric acid and 0.5g of menthol in 60.00g of distilled water. Stir at a constant speed at 90°C for 30 minutes to obtain a solution phase II.

[0045] 3. Mix the uniformly dispersed phase I with the solution phase II, and stir at a constant speed for 30 minutes until the mixture is uniform. Dry at 75° C. for 15 minutes to obtain a drug-containing matrix.

[0046] 4. Evenly coat the drug-containing matrix on the non-woven fabric of the backing layer, cover with a protective layer, mold it, and then cut it into the required sample size as needed.

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Abstract

The invention discloses novel levo-carnitine hydrogel patch and a preparation method thereof. According to the hydrogel patch, levo-carnitine is used as an active ingredient of medicines. The levo-carnitine hydrogel patch consists of a medicine-containing matrix layer, a backing layer and a protective layer, wherein the medicine-containing matrix layer comprises the levo-carnitine, a hydrogel matrix, a transdermal enhancer and a filling agent, wherein a mass ratio of the levo-carnitine to the hydrogel matrix is 1:(20-300), the transdermal enhancer accounts for 1 to 2 mass percent of the mass of the hydrogel matrix, and a tackifier accounts for 1 to 5 mass percent of the mass of the hydrogel matrix. According to the levo-carnitine hydrogel patch, the medicines can be released stably by the specific transdermal enhancer used by the levo-carnitine, and the accumulative transit dose within 12 hours can reach 900 ug.cm<-2>. Simultaneously, the characteristics of the direct administration and multi-component and large-dose administration of lesion sites can be achieved, and the compliance of the long-term administration of patients is improved; and the using effect of the levo-carnitine hydrogel patch is obviously superior to that of other conventional preparations of the levo-carnitine.

Description

technical field [0001] The invention relates to a novel L-carnitine hydrogel patch and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] L-carnitine, also known as L-carnitine or carnitine, is a vitamin-like substance. As an important carrier for transporting fatty acids into mitochondria, L-carnitine can participate in sperm energy metabolism, reduce active oxidative substances in seminal plasma, stabilize sperm cell membrane, and resist sperm apoptosis. In recent years, it has been widely used in the treatment of male infertility. Currently, oral preparations of trace elements such as L-carnitine, vitamin E, zinc and selenium, and ATP injections are commonly used in medical treatment. Due to the large oral dose of the drug, it is inconvenient for patients to take it frequently. Especially after oral administration, the blood drug concentration is unbalanced, and L-carnitine is mainly balanced by the kidneys, and ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/205A61P15/08
Inventor 汪济奎田孝才聂亚楠刘延昌吴凯蔡昊郭卫红
Owner EAST CHINA UNIV OF SCI & TECH
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