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Application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and/or treating encephalopathy

A technology of hydroxybenzylidene acetone and medicine, which is applied to the application field of p-hydroxybenzylidene acetone in the preparation of drugs for preventing and/or treating encephalopathy, can solve problems such as inability to infer the prevention and/or treatment of encephalopathy, and achieve anti-cerebral ischemia. and reperfusion injury, excellent curative effect, anti-brain injury effect

Inactive Publication Date: 2012-10-03
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no report that p-hydroxybenzylideneacetone is used as a brain protective agent, for the prevention and / or treatment of encephalopathy, and it is impossible to infer whether it has the effect of preventing and / or treating encephalopathy from the known properties of p-hydroxybenzylideneacetone

Method used

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  • Application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and/or treating encephalopathy
  • Application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and/or treating encephalopathy
  • Application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and/or treating encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The invention relates to an experiment on the effect of p-hydroxybenzylidene acetone on cultured brain nerve cells.

[0037] 1 ,Experimental Materials

[0038] There were 18 ordinary Sprague Dawley rats, weighing 250-280 g. Polylysine is a product of Sigma; DMEM medium is a product of Gibco; other reagents are of analytical grade.

[0039] 2. Primary culture of nerve cells

[0040] Anesthetize the 15-day pregnant rat with chloral hydrate, sterilize the chest and abdomen with 75% ethanol, take out the fetal mouse under aseptic conditions, peel off, separate the cortical tissue on both sides, cut it into mince with a scalpel, and transfer it into a medium containing 0.125% trypsin. After digesting in phosphate buffer for 30 min (37°C), discard the digestion solution, add DMED culture solution containing 10% fetal bovine serum, 10% horse serum, 100U / ml penicillin, 100U / ml streptomycin, and use a small-bore pipette Repeatedly blow and beat to disperse, filter through...

Embodiment 2

[0050] This experiment involves the protective effect of p-hydroxybenzylidene acetone on mice with closed traumatic brain injury.

[0051] 1. Experimental equipment

[0052] The automatic recorder for the jumping experiment was from the Instrument and Electricity Department of the Institute of Materia Medica, Chinese Academy of Medical Sciences; the fluorescence spectrophotometer was from HITACHI Corporation of Japan; and the microplate reader.

[0053] 2. Experimental animals

[0054] Clean grade Kunming mice, weighing 20-22g.

[0055] 3. Experiment

[0056] 60 mice were randomly divided into six groups: (1) normal control group; (2) model group; (3) p-hydroxybenzylidene acetone 1 mg / kg (diluted with 5% glucose injection to an appropriate level when using the drug) concentration) group; (4) p-hydroxybenzylidene acetone 2 mg / kg group; (5) p-hydroxybenzylidene acetone 4 mg / kg group; (6) ATP (adenosine triphosphate disodium) 4 mg / kg group, 10 rats in each group .

[0...

Embodiment 3

[0061] This example relates to the neuroprotective effect experiment of p-hydroxybenzylidene acetone on mice with vascular dementia.

[0062] Drugs and experimental equipment: p-Hydroxybenzylideneacetone: when used, dilute it with 5% glucose injection to an appropriate concentration. The automatic recorder for the jumping experiment is a product of the Instrument and Electricity Laboratory of the Institute of Materia Medica, Chinese Academy of Medical Sciences; the fluorescence spectrophotometer is a product of HITACHI Japan; the microplate reader.

[0063] Experimental animals: clean-grade Kunming mice, weighing 20-22 g.

[0064] 1. Improvement effect of p-hydroxybenzylidene acetone on learning and memory dysfunction in cerebral ischemia-reperfusion mice

[0065] 50 mice were randomly divided into five groups: (1) sham operation group; (2) model group; (3) p-hydroxybenzylidene acetone 1 mg / kg group; (4) p-hydroxybenzylidene acetone 2 mg / kg kg group; (5) p-hydroxybenzaceto...

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Abstract

The invention discloses an application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and / or treating encephalopathy, and particularly relates to the application of p-hydroxy benzylidene acetone in preparation of drugs for treating and / or preventing cerebral injury diseases or cerebrovascular diseases. The pharmacological research provided by the invention discovers that p-hydroxy benzylidene acetone has good treating function for cerebral ischemia and cerebral ischemia reperfusion injury when the p-hydroxy benzylidene acetone is applied to prepare drugs for treating cerebrovascular diseases. The research provided by the invention suggests that p-hydroxy benzylidene acetone is a compound with good treating effect and low toxic and adverse effects from the aspects of cerebral physiological function, nerve cell biochemistry and pathomorphology, has a better treating effect than the existing related drugs for treating cerebrovascular diseases, and is possibly developed into a new drug for treating cerebrovascular diseases, cerebral ischemia and cerebral ischemia reperfusion injury and cerebral injury.

Description

technical field [0001] The invention relates to a new application of p-hydroxybenzylideneacetone, in particular to the application of p-hydroxybenzylideneacetone in the preparation of drugs for preventing and / or treating encephalopathy. Background technique [0002] Encephalopathy refers to any organic brain damage, which is a disease of brain nerve tissue damage caused by genetics, congenital brain hypoplasia, brain trauma, brain tumors, cerebral hemorrhage, cerebral infarction, infection, and chemical drug poisoning. Common encephalopathy can be divided into three categories: one is children with cerebral palsy and mental retardation caused by heredity and congenital dysplasia; Chronic degenerative diseases in which nerve fiber damage leads to aging and degeneration of brain nerve cells, including Alzheimer's disease, brain atrophy, Parkinson's disease, etc. [0003] Throughout all kinds of encephalopathy, due to the blockage of nerve information transmission channel (bra...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P9/00A61P9/10A61P25/00
Inventor 李茹冰吴新荣李健孙智平陈新季波袁进黄涛阳
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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