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Solid molecular iodine disinfectant and preparation method thereof

A disinfectant preparation and molecular technology, which is applied in the field of medicine, can solve the problems of affecting the sterilization effect, affecting the appearance, and low allergies of auxiliary materials, and achieves the effect of remarkable sterilization effect, safe and convenient carrying, and good sterilization effect

Active Publication Date: 2012-10-03
山东沙多普生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the currently used iodine preparations have great defects: such as iodine (tincture of iodine), etc., have strong dyeing properties, allergies of excipients and low activity
The main reason for the low activity of the current iodine preparations is that the content of free iodine molecules in the entire iodine preparation is too low, and its content continues to decrease over time, while the content of other forms of iodine ions with weak bactericidal effects is low. very high
This not only affects the bactericidal effect of iodine, but also has a strong stimulating effect on human skin, and will produce strong yellow dyeing at the action site, affecting the appearance
And because iodine is volatile, if iodine is placed in the form of molecules for a long time, the content of active ingredients will drop a lot, which will affect the final use of bactericidal effect
In order to ensure the disinfection effect of iodine (tincture of iodine), a higher iodine concentration is generally used, which leads to greater skin irritation when used
These defects greatly limit the scope of application of iodine

Method used

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  • Solid molecular iodine disinfectant and preparation method thereof
  • Solid molecular iodine disinfectant and preparation method thereof
  • Solid molecular iodine disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Potassium iodide 30g, sodium iodate 10g, sodium bicarbonate 1g, and mannitol 19g were pulverized and passed through a 100-mesh sieve, mixed uniformly, and the sampling inspection was qualified, and the powder 1 was obtained by packaging. 30 g of citric acid and 20 g of sorbitol were pulverized and passed through a 100-mesh sieve, mixed uniformly, passed the sampling inspection, and then packed to obtain powder 2.

[0044] When in use, mix and dissolve powder 1, powder 2 and water at a ratio of 1:1:1000 (that is, dissolve 1 gram of powder 1 and 1 gram of powder 2 in 1,000 grams of water), and then it can be made into a disinfectant for disinfection.

[0045] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 minutes >5.00.

Embodiment 2

[0047]60g of sodium iodide, 30g of potassium iodate, 2g of sodium carbonate, and 8g of lactose were pulverized and passed through a 90-mesh sieve, mixed evenly, and the sampling inspection was qualified, and the powder was packaged to obtain powder 1. 80 g of tartaric acid and 20 g of fillers mannitol and sorbitol were pulverized and passed through a 90-mesh sieve, mixed uniformly, and the sampling test was qualified, and then packed to obtain powder 2.

[0048] When in use, mix and dissolve powder 1, powder 2 and water at a ratio of 1:1:1000 (that is, dissolve 1 gram of powder 1 and 1 gram of powder 2 in 1,000 grams of water), and then it can be made into a disinfectant for disinfection.

[0049] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia ...

Embodiment 3

[0051] 40g of calcium iodide, 15g of magnesium iodate, and 10g of sorbitol were pulverized and passed through an 800-mesh sieve, mixed evenly, and the sampling inspection was qualified, and the powder was packaged to obtain powder 1. Pulverize 50 g of fumaric acid and 10 g of microcrystalline cellulose, pass through an 80-mesh sieve, mix evenly, pass sampling inspection, and then pack to obtain powder 2.

[0052] When in use, mix and dissolve powder 1, powder 2 and water at a ratio of 1:1:1000 (that is, dissolve 1 gram of powder 1 and 1 gram of powder 2 in 1,000 grams of water), and then it can be made into a disinfectant for disinfection.

[0053] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 minutes >5.00.

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Abstract

The invention discloses a solid molecular iodine disinfectant and a preparation method thereof. The disinfectant comprises an iodide, an oxidant capable of oxidizing the iodide into iodine molecules, and a pH regulator for regulating the mixture of the iodide and the oxidant to be acidic; the disinfectant consists of a preparation 1 containing the iodide and the oxidant and a preparation 2 containing the pH regulator; and the preparation 1 and the preparation 2 are in a solid state. The disinfectant is high in stability and remarkable in disinfection effect; and due to high water solubility of main agents and auxiliary materials, the disinfectant can be quickly dissolved in water and is safe and convenient to use and carry. Because the raw materials are nontoxic, the disinfectant can be used for soaking disinfection of skin and can also be used for treating various skin diseases caused by bacteria, fungi and viruses.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a solid molecular iodine disinfection preparation for skin disinfection and a preparation method thereof. Background technique [0002] Iodine is a commonly used disinfection product, especially preparations such as iodine (tincture of iodine) are familiar disinfection products, and are widely used in hospitals and daily life. Iodine is one of the broadest-spectrum disinfectants, which can kill 100% of various bacteria, fungi, viruses and other microorganisms without producing drug resistance. So far, no microorganisms resistant to iodine have been found in the world. [0003] However, there are great defects in the currently used iodine preparations: such as iodine (tincture of iodine) etc. have strong dyeing properties and allergies of auxiliary materials and low activity. The main reason for the low activity of the current iodine preparations is that the content of free iod...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K33/34A61K33/32A61K33/30A61K9/46A61K9/16A61K9/14A61P31/00
Inventor 郑中立孙国玲
Owner 山东沙多普生物科技有限公司
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