Hydrophilic Chinese medicinal patch and preparation method thereof

A traditional Chinese medicine patch and hydrophilic technology, which is applied in the field of medicine, can solve the problems of unrelieved drug potency, poor drug transdermal effect, skin irritation, etc., and achieve remarkable economic and social benefits, simple and easy production process, and definite curative effect

Inactive Publication Date: 2012-10-03
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to solve the defects of the prior art, the content of the present invention is to provide a kind of hydrophilic traditional Chinese medicine plaster and its preparation method, which can effectively solve the problems of small effective drug storage capacity, airtightness and drug transdermal effect of the existing plaster. Poor, easily irritated to the skin and cause allergies, problems that cannot be relieved by medicine

Method used

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  • Hydrophilic Chinese medicinal patch and preparation method thereof
  • Hydrophilic Chinese medicinal patch and preparation method thereof
  • Hydrophilic Chinese medicinal patch and preparation method thereof

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Effect test

preparation example Construction

[0013] The preparation method of the hydrophilic traditional Chinese medicine patch comprises the following steps: (1) adding water to swell carbomer, adding triethanolamine to adjust the pH to 7.0-10.0; adding 3-5 times the weight of carbomer to medicinal gelatin or edible gelatin Dissolve in water at 35-60°C to obtain gelatin solution; add 5-10 times the weight of water to dissolve tragacanth gum to obtain tragacanth gum solution; ; adding gelatin solution, tragacanth gum solution and polysaccharide solution to the swollen carbomer, mixing evenly to obtain matrix I;

[0014] (2) Mix glycerin and propylene glycol evenly, add carboxymethylcellulose sodium, medicinal sodium polyacrylate, citric acid, eucalyptus oil, frankincense and myrrh crushed to the finest powder, kaolin or diatomaceous earth in sequence, and mix well Substrate II is obtained later;

[0015] (3) Mix base I and base II uniformly at 35-60°C, and add the alcohol-soluble extract of traditional Chinese medicine...

Embodiment 1

[0018] Calculated by the following weight percentages: medicinal sodium polyacrylate 5%, medicinal gelatin or edible gelatin 5%, carboxymethylcellulose sodium 1.0%, citric acid 0.2%, carbomer 12%, tragacanth gum 1% , frankincense 0.2%, myrrh 0.2%, traditional Chinese medicine compound extract polysaccharide 2%, traditional Chinese medicine compound alcohol-soluble extract 15%, kaolin or diatomaceous earth 4.5%, glycerin 10%, propylene glycol 3.0%, eucalyptus oil 0.2%, borneol 1.6 %, menthol 0.1%, water 39%;

[0019] The alcohol-soluble extract of the traditional Chinese medicine compound is calculated by the following weight percentages: 5% of Aconitum aconitum, 13% of Aconitum aconitum, 16% of Strychnis chinensis, 15% of Panax notoginseng, 7% of Speranthum spp., 7% of Xugufeng , Angelica 7%, Rhizoma Chuanxiong 7%, Clematis 7%, Duhuo 8%, Phellodendron Phellodendron 8% are made as raw materials, wherein the above-mentioned raw materials are first mixed and pulverized, and the c...

Embodiment 2

[0022] The present invention is calculated by the following weight percentages: by the following weight percentages: medicinal sodium polyacrylate 8%, medicinal gelatin or edible gelatin 1.6%, carboxymethyl cellulose sodium 3%, citric acid 0.8%, carbomer 2%, tragacanth gum 5%, frankincense 1.5%, myrrh 1.5%, traditional Chinese medicine compound extract polysaccharide 10%, traditional Chinese medicine compound alcohol-soluble extract 2%, kaolin or diatomaceous earth 5%, glycerin 25%, propylene glycol 8% , eucalyptus oil 2%, borneol 0.1%, menthol 2.1%, water 22.4%;

[0023] The alcohol-soluble extract of the traditional Chinese medicine compound is calculated by the following weight percentages: 13% of Aconitum aconitum, 5% of Aconitum aconitum, 4% of Strychnis chinensis, 5% of Panax notoginseng, 13.4% of Sperantoides 13.4%, and 13.5% of Xugufeng , Angelica 11.5%, Rhizoma Chuanxiong 11.6%, Clematis 7%, Duhuo 8%, Phellodendron Phellodendron 8% are made as raw materials, wherein t...

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Abstract

The invention relates to hydrophilic Chinese medicinal patch and a preparation method thereof, and can effectively solve the problems that the package size of the effective medicines of the conventional patch is small, and the conventional patch is airtight. According to the technical scheme, a gelatin solution, a tragacanth solution and a Chinese herbal compound extraction polysaccharide solution are added into swelled Carbomer and mixed uniformly to prepare a substrate I; glycerin is mixed with propylene glycol uniformly, and sodium carboxy methyl cellulose, medicinal sodium polyacrylate, citric acid, eucalyptus oil, frankincense, myrrh, kaolin and diatomaceous earth are sequentially added into the mixture of the glycerin and propylene glycol and mixed uniformly to prepare a substrate II; the substrate I is mixed with the substrate II uniformly, a Chinese herbal compound alcohol soluble extract, borneol and menthol are added into the mixed substrate of the substrate I and the substrate II, fully and uniformly mixed, coated, cut and packaged to prepare the hydrophilic Chinese medicinal patch. The Chinese medicinal patch is reasonable in compatibility, has an exact reliable in curative effect and big viscosity, and is difficult to fall off, and favorable for transdermal absorption of skin; a manufacturing process is simple, practicable and economic; and the social benefit is obvious.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hydrophilic traditional Chinese medicine patch and a preparation method thereof. Background technique [0002] Plaster is an important part of traditional medicine in my country. It has a history of more than 2,000 years. It has advantages that other dosage forms cannot match. It is convenient to use, can be administered continuously, and can be interrupted at any time. After effect, the blood concentration is stable. The plasters currently on the market mainly use traditional rubber plasters or hot-melt pressure-sensitive adhesives as matrix materials. These matrix materials are large and thin in appearance. Stimulating allergies and unable to alleviate the efficacy of the drug, generally only fat-soluble drugs can be loaded, which greatly limits the development of plasters. Traditional gel patches have high matrix content, low water retention, and low matrix viscosity. Contents of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K47/42A61K9/70A61P29/00A61P19/02A61P19/04A61P21/00A61P19/08
Inventor 刘富岗杨云
Owner HENAN UNIV OF CHINESE MEDICINE
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