Preparation method of alkyl trimethylammonium calcium oxytetracycline
A technology of alkyl trimethyl ammonium and calcitetracycline is applied in the preparation of amino compounds, the preparation of organic compounds, the preparation of carboxylic acid amides, etc., to achieve the effects of good fluidity, mild conditions and uniform particles
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Embodiment 1
[0023] Weigh 60 g of oxytetracycline and disperse it in 500 mL of deionized water, then add concentrated sulfuric acid with a mass ratio concentration of 98% while stirring, slowly adjust the pH of the oxytetracycline solution to 1.2, and react at a temperature of 25 °C for 1 h Finally, stir until the oxytetracycline is completely dissolved, then add 18 g of calcium carbonate powder to the oxytetracycline solution, stir, and react at a temperature of 25°C for 3 h to obtain the reaction solution I, and then add twelve Alkyltrimethylammonium chloride 18 g, stirred, and reacted at a temperature of 25°C for 3 h to obtain reaction solution II, and then added a sodium hydroxide solution with a mass ratio concentration of 30% to the reaction solution II, and slowly adjusted The pH of the reaction solution II is 7.8, react at a temperature of 25°C for 2 hours to obtain the reaction solution III, and spray the reaction solution III with a spray drying tower, the inlet air temperature of...
Embodiment 2
[0025] Weigh 100 g of oxytetracycline, disperse it in 500 mL of deionized water, then add concentrated sulfuric acid with a mass ratio concentration of 98% while stirring, slowly adjust the pH of the oxytetracycline solution to 2.0, and react at a temperature of 28 °C for 1 After h, stir until the oxytetracycline is completely dissolved, then add 60 g of calcium carbonate powder to the oxytetracycline solution, stir, and maintain the reaction at a temperature of 28°C for 10 h to obtain the reaction solution I, and then add 60 g of octadecyltrimethylammonium chloride, stirring, and maintaining the reaction at a temperature of 28 °C for 20 h to obtain reaction solution II, and then adding a sodium hydroxide solution with a mass ratio concentration of 30% to the reaction solution II , slowly adjust the pH of the reaction solution II to 10.5, and react at a temperature of 20°C for 2 hours to obtain the reaction solution III, and spray the reaction solution III with a spray drying t...
Embodiment 3
[0027] Weigh 25 g of oxytetracycline, disperse it in 500 mL of deionized water, then add concentrated sulfuric acid with a mass ratio concentration of 98% while stirring, slowly adjust the pH of the oxytetracycline solution to 0.5, and react at a temperature of 20 °C for 1 After h, stir until the oxytetracycline is completely dissolved, then add 2.5 g of calcium carbonate powder to the oxytetracycline solution, stir, and maintain the reaction at a temperature of 20°C for 30 min to obtain the reaction solution I, and then add to the reaction solution I 2.5 g of octadecyltrimethylammonium chloride, stirred, and maintained at a temperature of 20°C for 30 minutes to obtain reaction solution II, and then added a sodium hydroxide solution with a mass ratio concentration of 30% to the reaction solution II , slowly adjust the pH of the reaction solution II to 7.0, and react at a temperature of 20°C for 1 h to obtain the reaction solution III, and spray the reaction solution III with a ...
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